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Hedgehog signaling maintains a tumor stem cell compartment in multiple myeloma.

Peacock CD, Wang Q, Gesell GS, Corcoran-Schwartz IM, Jones E, Kim J, Devereux WL, Rhodes JT, Huff CA, Beachy PA, Watkins DN, Matsui W.

Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):4048-53. Epub 2007 Feb 27.


Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer.

Watkins DN, Berman DM, Burkholder SG, Wang B, Beachy PA, Baylin SB.

Nature. 2003 Mar 20;422(6929):313-7. Epub 2003 Mar 5.


Activation of liver X receptors inhibits hedgehog signaling, clonogenic growth, and self-renewal in multiple myeloma.

Agarwal JR, Wang Q, Tanno T, Rasheed Z, Merchant A, Ghosh N, Borrello I, Huff CA, Parhami F, Matsui W.

Mol Cancer Ther. 2014 Jul;13(7):1873-81. doi: 10.1158/1535-7163.MCT-13-0997. Epub 2014 May 7.


Cyclopamine-mediated hedgehog pathway inhibition depletes stem-like cancer cells in glioblastoma.

Bar EE, Chaudhry A, Lin A, Fan X, Schreck K, Matsui W, Piccirillo S, Vescovi AL, DiMeco F, Olivi A, Eberhart CG.

Stem Cells. 2007 Oct;25(10):2524-33. Epub 2007 Jul 12.


Self-renewal of acute lymphocytic leukemia cells is limited by the Hedgehog pathway inhibitors cyclopamine and IPI-926.

Lin TL, Wang QH, Brown P, Peacock C, Merchant AA, Brennan S, Jones E, McGovern K, Watkins DN, Sakamoto KM, Matsui W.

PLoS One. 2010 Dec 28;5(12):e15262. doi: 10.1371/journal.pone.0015262.


Hedgehog promotes neovascularization in pancreatic cancers by regulating Ang-1 and IGF-1 expression in bone-marrow derived pro-angiogenic cells.

Nakamura K, Sasajima J, Mizukami Y, Sugiyama Y, Yamazaki M, Fujii R, Kawamoto T, Koizumi K, Sato K, Fujiya M, Sasaki K, Tanno S, Okumura T, Shimizu N, Kawabe J, Karasaki H, Kono T, Ii M, Bardeesy N, Chung DC, Kohgo Y.

PLoS One. 2010 Jan 21;5(1):e8824. doi: 10.1371/journal.pone.0008824.


Role of hedgehog signaling in ovarian cancer.

Bhattacharya R, Kwon J, Ali B, Wang E, Patra S, Shridhar V, Mukherjee P.

Clin Cancer Res. 2008 Dec 1;14(23):7659-66. doi: 10.1158/1078-0432.CCR-08-1414.


Modulators of the hedgehog signaling pathway.

Heretsch P, Tzagkaroulaki L, Giannis A.

Bioorg Med Chem. 2010 Sep 15;18(18):6613-24. doi: 10.1016/j.bmc.2010.07.038. Epub 2010 Jul 23. Review.


RARĪ±2 expression confers myeloma stem cell features.

Yang Y, Shi J, Tolomelli G, Xu H, Xia J, Wang H, Zhou W, Zhou Y, Das S, Gu Z, Levasseur D, Zhan F, Tricot G.

Blood. 2013 Aug 22;122(8):1437-47. doi: 10.1182/blood-2013-02-482919. Epub 2013 Jul 11.


Blockade of hedgehog signaling pathway as a therapeutic strategy for pancreatic cancer.

Xu FG, Ma QY, Wang Z.

Cancer Lett. 2009 Oct 8;283(2):119-24. doi: 10.1016/j.canlet.2009.01.014. Epub 2009 Feb 15. Review.


Twist1 and Snail link Hedgehog signaling to tumor-initiating cell-like properties and acquired chemoresistance independently of ABC transporters.

Kong Y, Peng Y, Liu Y, Xin H, Zhan X, Tan W.

Stem Cells. 2015 Apr;33(4):1063-74. doi: 10.1002/stem.1955.


Epidermal growth factor receptor and hedgehog signaling pathways are active in esophageal cancer cells from rat reflux model.

Sui G, Bonde P, Dhara S, Broor A, Wang J, Marti G, Feldmann G, Duncan M, Montgomery E, Maitra A, Harmon JW.

J Surg Res. 2006 Jul;134(1):1-9. Epub 2006 Feb 20.


Blockade of hedgehog signaling inhibits pancreatic cancer invasion and metastases: a new paradigm for combination therapy in solid cancers.

Feldmann G, Dhara S, Fendrich V, Bedja D, Beaty R, Mullendore M, Karikari C, Alvarez H, Iacobuzio-Donahue C, Jimeno A, Gabrielson KL, Matsui W, Maitra A.

Cancer Res. 2007 Mar 1;67(5):2187-96.


Role for hedgehog signaling in hepatic stellate cell activation and viability.

Sicklick JK, Li YX, Choi SS, Qi Y, Chen W, Bustamante M, Huang J, Zdanowicz M, Camp T, Torbenson MS, Rojkind M, Diehl AM.

Lab Invest. 2005 Nov;85(11):1368-80.


Hedgehog signaling is required for differentiation of endocardial progenitors in zebrafish.

Wong KS, Rehn K, Palencia-Desai S, Kohli V, Hunter W, Uhl JD, Rost MS, Sumanas S.

Dev Biol. 2012 Jan 15;361(2):377-91. doi: 10.1016/j.ydbio.2011.11.004. Epub 2011 Nov 12.


Combinatorial hedgehog and mitogen signaling promotes the in vitro expansion but not retinal differentiation potential of retinal progenitor cells.

Ringuette R, Wang Y, Atkins M, Mears AJ, Yan K, Wallace VA.

Invest Ophthalmol Vis Sci. 2014 Jan 2;55(1):43-54. doi: 10.1167/iovs.13-12592.


Combining hedgehog signaling inhibition with focal irradiation on reduction of pancreatic cancer metastasis.

Gu D, Liu H, Su GH, Zhang X, Chin-Sinex H, Hanenberg H, Mendonca MS, Shannon HE, Chiorean EG, Xie J.

Mol Cancer Ther. 2013 Jun;12(6):1038-48. doi: 10.1158/1535-7163.MCT-12-1030. Epub 2013 Mar 6.


Hedgehog signaling is active in human prostate cancer stroma and regulates proliferation and differentiation of adjacent epithelium.

Wilkinson SE, Furic L, Buchanan G, Larsson O, Pedersen J, Frydenberg M, Risbridger GP, Taylor RA.

Prostate. 2013 Dec;73(16):1810-23. doi: 10.1002/pros.22720. Epub 2013 Sep 16.


Paracrine Hedgehog signaling in cancer.

Theunissen JW, de Sauvage FJ.

Cancer Res. 2009 Aug 1;69(15):6007-10. doi: 10.1158/0008-5472.CAN-09-0756. Epub 2009 Jul 28. Review.

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