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Items: 1 to 20 of 112

1.

Impact of pro segments on the folding and function of human neutrophil alpha-defensins.

Wu Z, Li X, Ericksen B, de Leeuw E, Zou G, Zeng P, Xie C, Li C, Lubkowski J, Lu WY, Lu W.

J Mol Biol. 2007 Apr 27;368(2):537-49.

PMID:
17355880
2.

Molecular determinants for the interaction of human neutrophil alpha defensin 1 with its propeptide.

Zou G, de Leeuw E, Lubkowski J, Lu W.

J Mol Biol. 2008 Sep 19;381(5):1281-91. doi: 10.1016/j.jmb.2008.06.066.

PMID:
18616948
3.

From pro defensins to defensins: synthesis and characterization of human neutrophil pro alpha-defensin-1 and its mature domain.

Wu Z, Prahl A, Powell R, Ericksen B, Lubkowski J, Lu W.

J Pept Res. 2003 Aug;62(2):53-62.

PMID:
12823617
4.

High fidelity processing and activation of the human α-defensin HNP1 precursor by neutrophil elastase and proteinase 3.

Tongaonkar P, Golji AE, Tran P, Ouellette AJ, Selsted ME.

PLoS One. 2012;7(3):e32469. doi: 10.1371/journal.pone.0032469.

PMID:
22448222
5.

Productive folding of human neutrophil alpha-defensins in vitro without the pro-peptide.

Wu Z, Powell R, Lu W.

J Am Chem Soc. 2003 Mar 5;125(9):2402-3.

PMID:
12603122
6.

Why is the Arg5-Glu13 salt bridge conserved in mammalian alpha-defensins?

Wu Z, Li X, de Leeuw E, Ericksen B, Lu W.

J Biol Chem. 2005 Dec 30;280(52):43039-47.

PMID:
16246847
7.

Inhibition of bactericidal activity is maintained in a mouse alpha-defensin precursor with proregion truncations.

Figueredo SM, Ouellette AJ.

Peptides. 2010 Jan;31(1):9-15. doi: 10.1016/j.peptides.2009.10.004.

PMID:
19837119
8.

Toward understanding the cationicity of defensins. Arg and Lys versus their noncoded analogs.

Zou G, de Leeuw E, Li C, Pazgier M, Li C, Zeng P, Lu WY, Lubkowski J, Lu W.

J Biol Chem. 2007 Jul 6;282(27):19653-65.

PMID:
17452329
9.

Differential Processing of {alpha}- and {beta}-Defensin Precursors by Matrix Metalloproteinase-7 (MMP-7).

Wilson CL, Schmidt AP, Pirilä E, Valore EV, Ferri N, Sorsa T, Ganz T, Parks WC.

J Biol Chem. 2009 Mar 27;284(13):8301-11. doi: 10.1074/jbc.M809744200.

PMID:
19181662
10.

Anionic amino acids near the pro-alpha-defensin N terminus mediate inhibition of bactericidal activity in mouse pro-cryptdin-4.

Figueredo SM, Weeks CS, Young SK, Ouellette AJ.

J Biol Chem. 2009 Mar 13;284(11):6826-31. doi: 10.1074/jbc.M807024200.

PMID:
19106102
11.

In vitro activation of the rhesus macaque myeloid alpha-defensin precursor proRMAD-4 by neutrophil serine proteinases.

Kamdar K, Maemoto A, Qu X, Young SK, Ouellette AJ.

J Biol Chem. 2008 Nov 21;283(47):32361-8. doi: 10.1074/jbc.M805296200.

PMID:
18775986
12.

Invariant gly residue is important for α-defensin folding, dimerization, and function: a case study of the human neutrophil α-defensin HNP1.

Zhao L, Ericksen B, Wu X, Zhan C, Yuan W, Li X, Pazgier M, Lu W.

J Biol Chem. 2012 Jun 1;287(23):18900-12. doi: 10.1074/jbc.M112.355255.

PMID:
22496447
13.

SDF2L1, a component of the endoplasmic reticulum chaperone complex, differentially interacts with {alpha}-, {beta}-, and {theta}-defensin propeptides.

Tongaonkar P, Selsted ME.

J Biol Chem. 2009 Feb 27;284(9):5602-9. doi: 10.1074/jbc.M806664200.

PMID:
19109254
14.

Large-scale synthesis and functional elements for the antimicrobial activity of defensins.

Raj PA, Antonyraj KJ, Karunakaran T.

Biochem J. 2000 May 1;347 Pt 3:633-41.

PMID:
10769165
15.

Functional determinants of human enteric α-defensin HD5: crucial role for hydrophobicity at dimer interface.

Rajabi M, Ericksen B, Wu X, de Leeuw E, Zhao L, Pazgier M, Lu W.

J Biol Chem. 2012 Jun 22;287(26):21615-27. doi: 10.1074/jbc.M112.367995.

PMID:
22573326
16.

Electropositive charge in alpha-defensin bactericidal activity: functional effects of Lys-for-Arg substitutions vary with the peptide primary structure.

Llenado RA, Weeks CS, Cocco MJ, Ouellette AJ.

Infect Immun. 2009 Nov;77(11):5035-43. doi: 10.1128/IAI.00695-09.

PMID:
19737896
17.

Synthesis and characterization of human alpha-defensins 4-6.

Wu Z, Ericksen B, Tucker K, Lubkowski J, Lu W.

J Pept Res. 2004 Sep;64(3):118-25.

PMID:
15317502
18.

Matrix metalloproteinase-7 activation of mouse paneth cell pro-alpha-defensins: SER43 down arrow ILE44 proteolysis enables membrane-disruptive activity.

Weeks CS, Tanabe H, Cummings JE, Crampton SP, Sheynis T, Jelinek R, Vanderlick TK, Cocco MJ, Ouellette AJ.

J Biol Chem. 2006 Sep 29;281(39):28932-42.

PMID:
16822871
19.

Functional interaction of human neutrophil peptide-1 with the cell wall precursor lipid II.

de Leeuw E, Li C, Zeng P, Li C, Diepeveen-de Buin M, Lu WY, Breukink E, Lu W.

FEBS Lett. 2010 Apr 16;584(8):1543-8. doi: 10.1016/j.febslet.2010.03.004.

PMID:
20214904
20.
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