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Items: 1 to 20 of 101

1.

Synthesis of the antifungal beta-1,3-glucan synthase inhibitor CANCIDAS (caspofungin acetate) from pneumocandin B0.

Leonard WR Jr, Belyk KM, Conlon DA, Bender DR, DiMichele LM, Liu J, Hughes DL.

J Org Chem. 2007 Mar 30;72(7):2335-43. Epub 2007 Mar 8.

PMID:
17343416
2.

Discovery and development of first in class antifungal caspofungin (CANCIDAS®)--a case study.

Balkovec JM, Hughes DL, Masurekar PS, Sable CA, Schwartz RE, Singh SB.

Nat Prod Rep. 2014 Jan;31(1):15-34. doi: 10.1039/c3np70070d. Review.

PMID:
24270605
3.

Determination of the relative and absolute configuration of the dimethylmyristoyl side chain of pneumocandin B0 by asymmetric synthesis.

Leonard WR Jr, Belyk KM, Bender DR, Conlon DA, Hughes DL, Reider PJ.

Org Lett. 2002 Nov 28;4(24):4201-4.

PMID:
12443058
4.

Discovery of novel antifungal (1,3)-beta-D-glucan synthase inhibitors.

Onishi J, Meinz M, Thompson J, Curotto J, Dreikorn S, Rosenbach M, Douglas C, Abruzzo G, Flattery A, Kong L, Cabello A, Vicente F, Pelaez F, Diez MT, Martin I, Bills G, Giacobbe R, Dombrowski A, Schwartz R, Morris S, Harris G, Tsipouras A, Wilson K, Kurtz MB.

Antimicrob Agents Chemother. 2000 Feb;44(2):368-77.

5.

Preparation and evaluation of novel stationary phases for improved chromatographic purification of pneumocandin B0.

Welch CJ, DaSilva JO, Nti-Gyabaah J, Antia F, Goklen K, Boyd R.

J Chromatogr A. 2006 Jan 6;1101(1-2):204-13. Epub 2005 Oct 27.

PMID:
16257000
6.

[Antifungal inhibitors of glucan synthesis].

Romero M, Cantón E, Pemán J, Gobernado M.

Rev Esp Quimioter. 2005 Dec;18(4):281-99. Review. Spanish. No abstract available.

7.

Synthesis and antifungal activities of glycosylated derivatives of the cyclic peptide fungicide caspofungin.

Guo J, Hu H, Zhao Q, Wang T, Zou Y, Yu S, Wu Q, Guo Z.

ChemMedChem. 2012 Aug;7(8):1496-503. doi: 10.1002/cmdc.201200214. Epub 2012 Jun 8.

PMID:
22684908
8.
9.

Engineering of Glarea lozoyensis for exclusive production of the pneumocandin B0 precursor of the antifungal drug caspofungin acetate.

Chen L, Yue Q, Li Y, Niu X, Xiang M, Wang W, Bills GF, Liu X, An Z.

Appl Environ Microbiol. 2015 Mar;81(5):1550-8. doi: 10.1128/AEM.03256-14. Epub 2014 Dec 19.

10.
11.

Pneumocandins from Zalerion arboricola. I. Discovery and isolation.

Schwartz RE, Sesin DF, Joshua H, Wilson KE, Kempf AJ, Goklen KA, Kuehner D, Gailliot P, Gleason C, White R, et al.

J Antibiot (Tokyo). 1992 Dec;45(12):1853-66.

12.

Synthesis and antifungal activity of novel cationic pneumocandin B(o) derivatives.

Bouffard FA, Zambias RA, Dropinski JF, Balkovec JM, Hammond ML, Abruzzo GK, Bartizal KF, Marrinan JA, Kurtz MB, McFadden DC, et al.

J Med Chem. 1994 Jan 21;37(2):222-5. No abstract available.

PMID:
8295208
13.

Synthesis of antifungal glucan synthase inhibitors from enfumafungin.

Zhong YL, Gauthier DR Jr, Shi YJ, McLaughlin M, Chung JY, Dagneau P, Marcune B, Krska SW, Ball RG, Reamer RA, Yasuda N.

J Org Chem. 2012 Apr 6;77(7):3297-310. doi: 10.1021/jo300046v. Epub 2012 Mar 28.

PMID:
22423625
14.

Caspofungin: an overview.

Morrison VA.

Expert Rev Anti Infect Ther. 2005 Oct;3(5):697-705. Review.

PMID:
16207161
15.

Total synthesis of the antifungal depsipeptide petriellin A.

Sleebs MM, Scanlon D, Karas J, Maharani R, Hughes AB.

J Org Chem. 2011 Aug 19;76(16):6686-93. doi: 10.1021/jo201017w. Epub 2011 Jul 19.

PMID:
21739964
16.

Synthesis and evaluation of novel macrocyclic antifungal peptides.

Mulder MP, Kruijtzer JA, Breukink EJ, Kemmink J, Pieters RJ, Liskamp RM.

Bioorg Med Chem. 2011 Nov 1;19(21):6505-17. doi: 10.1016/j.bmc.2011.08.034. Epub 2011 Aug 22.

PMID:
21940175
17.

From natural products to clinically useful antifungals.

Barrett D.

Biochim Biophys Acta. 2002 Jul 18;1587(2-3):224-33. Review.

18.

Update on antifungals targeted to the cell wall: focus on beta-1,3-glucan synthase inhibitors.

Georgopapadakou NH.

Expert Opin Investig Drugs. 2001 Feb;10(2):269-80. Review.

PMID:
11178340
19.

FK463, a novel water-soluble echinocandin lipopeptide: synthesis and antifungal activity.

Tomishima M, Ohki H, Yamada A, Takasugi H, Maki K, Tawara S, Tanaka H.

J Antibiot (Tokyo). 1999 Jul;52(7):674-6. No abstract available.

20.

Characterization and cilofungin inhibition of solubilized Aspergillus fumigatus (1,3)-beta-D-glucan synthase.

Beaulieu D, Tang J, Yan SB, Vessels JM, Radding JA, Parr TR Jr.

Antimicrob Agents Chemother. 1994 May;38(5):937-44.

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