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Items: 1 to 20 of 90

1.

Mitochondrial point mutations do not limit the natural lifespan of mice.

Vermulst M, Bielas JH, Kujoth GC, Ladiges WC, Rabinovitch PS, Prolla TA, Loeb LA.

Nat Genet. 2007 Apr;39(4):540-3. Epub 2007 Mar 4.

PMID:
17334366
2.

Does premature aging of the mtDNA mutator mouse prove that mtDNA mutations are involved in natural aging?

Khrapko K, Kraytsberg Y, de Grey AD, Vijg J, Schon EA.

Aging Cell. 2006 Jun;5(3):279-82.

3.

Mitochondrial DNA mutations and aging.

Krishnan KJ, Greaves LC, Reeve AK, Turnbull DM.

Ann N Y Acad Sci. 2007 Apr;1100:227-40. Review.

PMID:
17460184
4.

DNA deletions and clonal mutations drive premature aging in mitochondrial mutator mice.

Vermulst M, Wanagat J, Kujoth GC, Bielas JH, Rabinovitch PS, Prolla TA, Loeb LA.

Nat Genet. 2008 Apr;40(4):392-4. doi: 10.1038/ng.95. Epub 2008 Mar 2.

PMID:
18311139
5.

Evolving insight into the role of mitochondrial DNA mutations in aging.

Kujoth GC, Prolla TA.

Exp Gerontol. 2008 Jan;43(1):20-3. Epub 2007 Oct 5. Review.

PMID:
18054193
6.

Error catastrophe in mutant mitochondria.

Hoopes LL.

Sci Aging Knowledge Environ. 2002 Nov 13;2002(45):vp6.

PMID:
14603013
7.

Premature ageing in mice expressing defective mitochondrial DNA polymerase.

Trifunovic A, Wredenberg A, Falkenberg M, Spelbrink JN, Rovio AT, Bruder CE, Bohlooly-Y M, Gidlöf S, Oldfors A, Wibom R, Törnell J, Jacobs HT, Larsson NG.

Nature. 2004 May 27;429(6990):417-23.

PMID:
15164064
8.

Mitochondrial wrinkles: the first signs of ageing?

Raftopoulou M.

Nat Cell Biol. 2005 Sep;7(9):853. No abstract available.

PMID:
16136182
9.

Mitochondrial DNA mutations and apoptosis in mammalian aging.

Kujoth GC, Leeuwenburgh C, Prolla TA.

Cancer Res. 2006 Aug 1;66(15):7386-9. Review.

10.

Mitochondrial DNA mutations in mutator mice confer respiration defects and B-cell lymphoma development.

Mito T, Kikkawa Y, Shimizu A, Hashizume O, Katada S, Imanishi H, Ota A, Kato Y, Nakada K, Hayashi J.

PLoS One. 2013;8(2):e55789. doi: 10.1371/journal.pone.0055789. Epub 2013 Feb 13.

11.

Effects of mitochondrial mutations on hearing and cochlear pathology with age.

Crawley BK, Keithley EM.

Hear Res. 2011 Oct;280(1-2):201-8. doi: 10.1016/j.heares.2011.05.015. Epub 2011 Jun 1.

12.

Maternally transmitted mitochondrial DNA mutations can reduce lifespan.

Ross JM, Coppotelli G, Hoffer BJ, Olson L.

Sci Rep. 2014 Oct 9;4:6569. doi: 10.1038/srep06569.

13.

Evaluating evidence for aging.

Miller RA.

Science. 2005 Oct 21;310(5747):441-3; author reply 441-3. No abstract available.

PMID:
16239461
14.

Point mutations are causing progeroid phenotypes in the mtDNA mutator mouse.

Edgar D, Larsson NG, Trifunovic A.

Cell Metab. 2010 Jan;11(1):1. doi: 10.1016/j.cmet.2009.12.001. No abstract available.

15.

What the papers say: where is the somatic mutation that causes aging?

Driver C.

Bioessays. 2004 Nov;26(11):1160-3.

PMID:
15499582
16.

Variation in mitochondrial genotype has substantial lifespan effects which may be modulated by nuclear background.

Clancy DJ.

Aging Cell. 2008 Dec;7(6):795-804. doi: 10.1111/j.1474-9726.2008.00428.x. Epub 2008 Aug 21.

17.

Mitochondrial dysfunction as a cause of ageing.

Trifunovic A, Larsson NG.

J Intern Med. 2008 Feb;263(2):167-78. doi: 10.1111/j.1365-2796.2007.01905.x.

18.
19.

Analysis and modulation of DNA repair in aging.

Walter CA, Grabowski DT, Street KA, Conrad CC, Richardson A.

Mech Ageing Dev. 1997 Dec;98(3):203-22. Review.

PMID:
9352490
20.

Random point mutations with major effects on protein-coding genes are the driving force behind premature aging in mtDNA mutator mice.

Edgar D, Shabalina I, Camara Y, Wredenberg A, Calvaruso MA, Nijtmans L, Nedergaard J, Cannon B, Larsson NG, Trifunovic A.

Cell Metab. 2009 Aug;10(2):131-8. doi: 10.1016/j.cmet.2009.06.010.

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