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Items: 1 to 20 of 271

1.

Pharmacologically diverse antidepressants rapidly activate brain-derived neurotrophic factor receptor TrkB and induce phospholipase-Cgamma signaling pathways in mouse brain.

Rantamäki T, Hendolin P, Kankaanpää A, Mijatovic J, Piepponen P, Domenici E, Chao MV, Männistö PT, Castrén E.

Neuropsychopharmacology. 2007 Oct;32(10):2152-62.

2.

Activation of the TrkB neurotrophin receptor is induced by antidepressant drugs and is required for antidepressant-induced behavioral effects.

Saarelainen T, Hendolin P, Lucas G, Koponen E, Sairanen M, MacDonald E, Agerman K, Haapasalo A, Nawa H, Aloyz R, Ernfors P, Castrén E.

J Neurosci. 2003 Jan 1;23(1):349-57.

3.

Antidepressant drugs transactivate TrkB neurotrophin receptors in the adult rodent brain independently of BDNF and monoamine transporter blockade.

Rantamäki T, Vesa L, Antila H, Di Lieto A, Tammela P, Schmitt A, Lesch KP, Rios M, Castrén E.

PLoS One. 2011;6(6):e20567. doi: 10.1371/journal.pone.0020567.

4.

The VGF-derived peptide TLQP62 produces antidepressant-like effects in mice via the BDNF/TrkB/CREB signaling pathway.

Lin P, Wang C, Xu B, Gao S, Guo J, Zhao X, Huang H, Zhang J, Chen X, Wang Q, Zhou W.

Pharmacol Biochem Behav. 2014 May;120:140-8. doi: 10.1016/j.pbb.2014.03.003.

PMID:
24631486
5.
6.

Antidepressant-like effects of alarin produced by activation of TrkB receptor signaling pathways in chronic stress mice.

Wang M, Zhou W, Zhou X, Zhuang F, Chen Q, Li M, Ma T, Gu S.

Behav Brain Res. 2015 Mar 1;280:128-40. doi: 10.1016/j.bbr.2014.11.039.

PMID:
25476565
7.

Nimodipine activates TrkB neurotrophin receptors and induces neuroplastic and neuroprotective signaling events in the mouse hippocampus and prefrontal cortex.

Koskimäki J, Matsui N, Umemori J, Rantamäki T, Castrén E.

Cell Mol Neurobiol. 2015 Mar;35(2):189-96. doi: 10.1007/s10571-014-0110-5.

PMID:
25204460
8.

Enhanced BDNF signaling is associated with an antidepressant-like behavioral response and changes in brain monoamines.

Koponen E, Rantamäki T, Voikar V, Saarelainen T, MacDonald E, Castrén E.

Cell Mol Neurobiol. 2005 Sep;25(6):973-80.

PMID:
16392030
10.

Serotonin 2C receptor antagonists induce fast-onset antidepressant effects.

Opal MD, Klenotich SC, Morais M, Bessa J, Winkle J, Doukas D, Kay LJ, Sousa N, Dulawa SM.

Mol Psychiatry. 2014 Oct;19(10):1106-14. doi: 10.1038/mp.2013.144.

PMID:
24166413
11.

Calcineurin (protein phosphatase 2B) is involved in the mechanisms of action of antidepressants.

Crozatier C, Farley S, Mansuy IM, Dumas S, Giros B, Tzavara ET.

Neuroscience. 2007 Feb 23;144(4):1470-6.

PMID:
17207580
13.

Role of BDNF/TrkB signaling in antidepressant-like effects of a group II metabotropic glutamate receptor antagonist in animal models of depression.

Koike H, Fukumoto K, Iijima M, Chaki S.

Behav Brain Res. 2013 Feb 1;238:48-52. doi: 10.1016/j.bbr.2012.10.023.

PMID:
23098797
14.

Antidepressant effects of TrkB ligands on depression-like behavior and dendritic changes in mice after inflammation.

Zhang JC, Wu J, Fujita Y, Yao W, Ren Q, Yang C, Li SX, Shirayama Y, Hashimoto K.

Int J Neuropsychopharmacol. 2014 Oct 31;18(4). pii: pyu077. doi: 10.1093/ijnp/pyu077.

15.

Mechanism of TrkB-mediated hippocampal long-term potentiation.

Minichiello L, Calella AM, Medina DL, Bonhoeffer T, Klein R, Korte M.

Neuron. 2002 Sep 26;36(1):121-37.

16.

Phosphoproteomic analysis of neurotrophin receptor TrkB signaling pathways in mouse brain.

Semenov A, Goldsteins G, Castrén E.

Cell Mol Neurobiol. 2006 Mar;26(2):163-75.

PMID:
16612579
18.

Aging and a peripheral immune challenge interact to reduce mature brain-derived neurotrophic factor and activation of TrkB, PLCgamma1, and ERK in hippocampal synaptoneurosomes.

Cortese GP, Barrientos RM, Maier SF, Patterson SL.

J Neurosci. 2011 Mar 16;31(11):4274-9. doi: 10.1523/JNEUROSCI.5818-10.2011.

19.

Running exercise-induced up-regulation of hippocampal brain-derived neurotrophic factor is CREB-dependent.

Chen MJ, Russo-Neustadt AA.

Hippocampus. 2009 Oct;19(10):962-72. doi: 10.1002/hipo.20579.

20.

Analysis of dependence of antidepressant properties of TrkB receptor ligands on MAP-kinase pathway activation.

Gudasheva TA, Logvinov IO, Povarnina PY, Antipova TA, Seredenin SB.

Dokl Biochem Biophys. 2015;460:20-2. doi: 10.1134/S1607672915010068. No abstract available.

PMID:
25772983
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