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PEA-15 inhibits tumor cell invasion by binding to extracellular signal-regulated kinase 1/2.

Glading A, Koziol JA, Krueger J, Ginsberg MH.

Cancer Res. 2007 Feb 15;67(4):1536-44.


Akt down-regulates ERK1/2 nuclear localization and angiotensin II-induced cell proliferation through PEA-15.

Gervais M, Dugourd C, Muller L, Ardidie C, Canton B, Loviconi L, Corvol P, Chneiweiss H, Monnot C.

Mol Biol Cell. 2006 Sep;17(9):3940-51. Epub 2006 Jul 5.


The PEA-15/PED protein protects glioblastoma cells from glucose deprivation-induced apoptosis via the ERK/MAP kinase pathway.

Eckert A, Böck BC, Tagscherer KE, Haas TL, Grund K, Sykora J, Herold-Mende C, Ehemann V, Hollstein M, Chneiweiss H, Wiestler OD, Walczak H, Roth W.

Oncogene. 2008 Feb 14;27(8):1155-66. Epub 2007 Aug 13.


The anti-apoptotic protein PEA-15 is a tight binding inhibitor of ERK1 and ERK2, which blocks docking interactions at the D-recruitment site.

Callaway K, Abramczyk O, Martin L, Dalby KN.

Biochemistry. 2007 Aug 14;46(32):9187-98. Epub 2007 Jul 21.


LRRC4 inhibits human glioblastoma cells proliferation, invasion, and proMMP-2 activation by reducing SDF-1 alpha/CXCR4-mediated ERK1/2 and Akt signaling pathways.

Wu M, Chen Q, Li D, Li X, Li X, Huang C, Tang Y, Zhou Y, Wang D, Tang K, Cao L, Shen S, Li G.

J Cell Biochem. 2008 Jan 1;103(1):245-55.


Phosphoprotein enriched in astrocytes 15 kDa (PEA-15) reprograms growth factor signaling by inhibiting threonine phosphorylation of fibroblast receptor substrate 2alpha.

Haling JR, Wang F, Ginsberg MH.

Mol Biol Cell. 2010 Feb 15;21(4):664-73. doi: 10.1091/mbc.E09-08-0659. Epub 2009 Dec 23.


ERK1/2 associates with the c-Met-binding domain of growth factor receptor-bound protein 2 (Grb2)-associated binder-1 (Gab1): role in ERK1/2 and early growth response factor-1 (Egr-1) nuclear accumulation.

Osawa M, Itoh S, Ohta S, Huang Q, Berk BC, Marmarosh NL, Che W, Ding B, Yan C, Abe J.

J Biol Chem. 2004 Jul 9;279(28):29691-9. Epub 2004 Apr 12.


Kalopanaxsaponin A inhibits PMA-induced invasion by reducing matrix metalloproteinase-9 via PI3K/Akt- and PKCdelta-mediated signaling in MCF-7 human breast cancer cells.

Park SK, Hwang YS, Park KK, Park HJ, Seo JY, Chung WY.

Carcinogenesis. 2009 Jul;30(7):1225-33. doi: 10.1093/carcin/bgp111. Epub 2009 May 6.


[The PEA-15 protein induces resistance against glucose deprivation-induced cell death via the ERK/MAP kinase pathway].

Roth W, Eckert A, Böck B, Schirmacher P, Wiestler OD.

Verh Dtsch Ges Pathol. 2007;91:343-50. German.


The relaxin family peptide receptor 3 activates extracellular signal-regulated kinase 1/2 through a protein kinase C-dependent mechanism.

van der Westhuizen ET, Werry TD, Sexton PM, Summers RJ.

Mol Pharmacol. 2007 Jun;71(6):1618-29. Epub 2007 Mar 9.


A role for endothelin-2 and its receptors in breast tumor cell invasion.

Grimshaw MJ, Hagemann T, Ayhan A, Gillett CE, Binder C, Balkwill FR.

Cancer Res. 2004 Apr 1;64(7):2461-8.


Human biliverdin reductase is an ERK activator; hBVR is an ERK nuclear transporter and is required for MAPK signaling.

Lerner-Marmarosh N, Miralem T, Gibbs PE, Maines MD.

Proc Natl Acad Sci U S A. 2008 May 13;105(19):6870-5. doi: 10.1073/pnas.0800750105. Epub 2008 May 7.


Involvement of protein kinase C beta-extracellular signal-regulating kinase 1/2/p38 mitogen-activated protein kinase-heat shock protein 27 activation in hepatocellular carcinoma cell motility and invasion.

Guo K, Liu Y, Zhou H, Dai Z, Zhang J, Sun R, Chen J, Sun Q, Lu W, Kang X, Chen P.

Cancer Sci. 2008 Mar;99(3):486-96. doi: 10.1111/j.1349-7006.2007.00702.x. Epub 2007 Dec 27.


Focal adhesion kinase controls aggressive phenotype of androgen-independent prostate cancer.

Johnson TR, Khandrika L, Kumar B, Venezia S, Koul S, Chandhoke R, Maroni P, Donohue R, Meacham RB, Koul HK.

Mol Cancer Res. 2008 Oct;6(10):1639-48. doi: 10.1158/1541-7786.MCR-08-0052.


Dok-4 regulates GDNF-dependent neurite outgrowth through downstream activation of Rap1 and mitogen-activated protein kinase.

Uchida M, Enomoto A, Fukuda T, Kurokawa K, Maeda K, Kodama Y, Asai N, Hasegawa T, Shimono Y, Jijiwa M, Ichihara M, Murakumo Y, Takahashi M.

J Cell Sci. 2006 Aug 1;119(Pt 15):3067-77. Epub 2006 Jul 4.


The protein kinase C inhibitor, H7, inhibits tumor cell invasion and metastasis in mouse melanoma via suppression of ERK1/2.

Tsubaki M, Matsuoka H, Yamamoto C, Kato C, Ogaki M, Satou T, Itoh T, Kusunoki T, Tanimori Y, Nishida S.

Clin Exp Metastasis. 2007;24(6):431-8. Epub 2007 Jul 18.


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