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Novel functional interaction between Na+/H+ exchanger 1 and tyrosine phosphatase SHP-2.

Xue J, Zhou D, Yao H, Gavrialov O, McConnell MJ, Gelb BD, Haddad GG.

Am J Physiol Regul Integr Comp Physiol. 2007 Jun;292(6):R2406-16. Epub 2007 Feb 8. Erratum in: Am J Physiol Regul Integr Comp Physiol. 2007 Jul;293(1):R556.


Insulin inhibits Na+/H+ exchange in vascular smooth muscle and endothelial cells in situ: involvement of H2O2 and tyrosine phosphatase SHP-2.

Boedtkjer E, Aalkjaer C.

Am J Physiol Heart Circ Physiol. 2009 Feb;296(2):H247-55. doi: 10.1152/ajpheart.00725.2008. Epub 2008 Nov 26.


Interdependent regulation of intracellular acidification and SHP-1 in apoptosis.

Thangaraju M, Sharma K, Liu D, Shen SH, Srikant CB.

Cancer Res. 1999 Apr 1;59(7):1649-54.


The N-terminal SH2 domain of the tyrosine phosphatase, SHP-2, is essential for Jak2-dependent signaling via the angiotensin II type AT1 receptor.

Godeny MD, Sayyah J, VonDerLinden D, Johns M, Ostrov DA, Caldwell-Busby J, Sayeski PP.

Cell Signal. 2007 Mar;19(3):600-9. Epub 2006 Sep 1.


Calmodulin-binding autoinhibitory domain controls "pH-sensing" in the Na+/H+ exchanger NHE1 through sequence-specific interaction.

Wakabayashi S, Ikeda T, Iwamoto T, Pouysségur J, Shigekawa M.

Biochemistry. 1997 Oct 21;36(42):12854-61.


A novel protein-protein interaction between a G protein-coupled receptor and the phosphatase SHP-2 is involved in bradykinin-induced inhibition of cell proliferation.

Duchene J, Schanstra JP, Pecher C, Pizard A, Susini C, Esteve JP, Bascands JL, Girolami JP.

J Biol Chem. 2002 Oct 25;277(43):40375-83. Epub 2002 Aug 12.


Mechanisms of hypotonic inhibition of the sodium, proton exchanger type 1 (NHE1) in a biliary epithelial cell line (Mz-Cha-1).

Elsing C, Gosch I, Hennings JC, Hübner CA, Herrmann T.

Acta Physiol (Oxf). 2007 Jul;190(3):199-208.


SHP-2 phosphatase is required for hematopoietic cell transformation by Bcr-Abl.

Chen J, Yu WM, Daino H, Broxmeyer HE, Druker BJ, Qu CK.

Blood. 2007 Jan 15;109(2):778-85. Epub 2006 Sep 26.


Na(+)/H(+) exchanger NHE1 as plasma membrane scaffold in the assembly of signaling complexes.

Baumgartner M, Patel H, Barber DL.

Am J Physiol Cell Physiol. 2004 Oct;287(4):C844-50. Review.


Increased tolerance to oxygen and glucose deprivation in astrocytes from Na(+)/H(+) exchanger isoform 1 null mice.

Kintner DB, Su G, Lenart B, Ballard AJ, Meyer JW, Ng LL, Shull GE, Sun D.

Am J Physiol Cell Physiol. 2004 Jul;287(1):C12-21. Epub 2004 Mar 10.


Oxidation sensitivity of the catalytic cysteine of the protein-tyrosine phosphatases SHP-1 and SHP-2.

Weibrecht I, Böhmer SA, Dagnell M, Kappert K, Ostman A, Böhmer FD.

Free Radic Biol Med. 2007 Jul 1;43(1):100-10. Epub 2007 Mar 31.


Sprouty proteins are in vivo targets of Corkscrew/SHP-2 tyrosine phosphatases.

Jarvis LA, Toering SJ, Simon MA, Krasnow MA, Smith-Bolton RK.

Development. 2006 Mar;133(6):1133-42. Epub 2006 Feb 15.


Protein phosphatase regulation of Na+/H+ exchanger isoform I.

Misik AJ, Perreault K, Holmes CF, Fliegel L.

Biochemistry. 2005 Apr 19;44(15):5842-52.


EGF-stimulation activates the nuclear localization signal of SHP-1.

He D, Song X, Liu L, Burk DH, Zhou GW.

J Cell Biochem. 2005 Apr 1;94(5):944-53.


The Lipoxin A4 receptor is coupled to SHP-2 activation: implications for regulation of receptor tyrosine kinases.

Mitchell D, O'Meara SJ, Gaffney A, Crean JK, Kinsella BT, Godson C.

J Biol Chem. 2007 May 25;282(21):15606-18. Epub 2007 Apr 2.


Inhibition of IFN-alpha signaling by a PKC- and protein tyrosine phosphatase SHP-2-dependent pathway.

Du Z, Shen Y, Yang W, Mecklenbrauker I, Neel BG, Ivashkiv LB.

Proc Natl Acad Sci U S A. 2005 Jul 19;102(29):10267-72. Epub 2005 Jul 6.


Tyrosine phosphatases such as SHP-2 act in a balance with Src-family kinases in stabilization of postsynaptic clusters of acetylcholine receptors.

Camilleri AA, Willmann R, Sadasivam G, Lin S, Rüegg MA, Gesemann M, Fuhrer C.

BMC Neurosci. 2007 Jul 2;8:46.

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