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Interleukin 7 reduces the levels of spontaneous apoptosis in CD4+ and CD8+ T cells from HIV-1-infected individuals.

Vassena L, Proschan M, Fauci AS, Lusso P.

Proc Natl Acad Sci U S A. 2007 Feb 13;104(7):2355-60. Epub 2007 Feb 6.


Interferon-alpha differentially rescues CD4 and CD8 T cells from apoptosis in HIV infection.

Rodriguez B, Lederman MM, Jiang W, Bazdar DA, Gàrate K, Harding CV, Sieg SF.

AIDS. 2006 Jun 26;20(10):1379-89.


Interleukin 7 increases human immunodeficiency virus type 1 LAI-mediated Fas-induced T-cell death.

Lelièvre JD, Petit F, Arnoult D, Ameisen JC, Estaquier J.

J Virol. 2005 Mar;79(5):3195-9.


Anti-retroviral therapy in HIV-infected patients: in vitro effects of AZT and saquinavir on the response of CD4 and CD8 lymphocytes to interleukin-7.

Beq S, Bugault F, Colle JH, Lambotte O, Delfraissy JF, Thèze J.

Eur Cytokine Netw. 2005 Dec;16(4):293-9.


CD4 and CD8 T cell immune activation during chronic HIV infection: roles of homeostasis, HIV, type I IFN, and IL-7.

Catalfamo M, Wilhelm C, Tcheung L, Proschan M, Friesen T, Park JH, Adelsberger J, Baseler M, Maldarelli F, Davey R, Roby G, Rehm C, Lane C.

J Immunol. 2011 Feb 15;186(4):2106-16. doi: 10.4049/jimmunol.1002000. Epub 2011 Jan 21.


Coinfection with hepatitis C virus increases lymphocyte apoptosis in HIV-infected patients.

Núñez M, Soriano V, López M, Ballesteros C, Cascajero A, González-Lahoz J, Benito JM.

Clin Infect Dis. 2006 Nov 1;43(9):1209-12. Epub 2006 Sep 27.


Responsiveness of T cells to interleukin-7 is associated with higher CD4+ T cell counts in HIV-1-positive individuals with highly active antiretroviral therapy-induced viral load suppression.

Camargo JF, Kulkarni H, Agan BK, Gaitan AA, Beachy LA, Srinivas S, He W, Anderson S, Marconi VC, Dolan MJ, Ahuja SK.

J Infect Dis. 2009 Jun 15;199(12):1872-82. doi: 10.1086/598858.


Effect of L-carnitine on human immunodeficiency virus-1 infection-associated apoptosis: a pilot study.

Moretti S, Alesse E, Di Marzio L, Zazzeroni F, Ruggeri B, Marcellini S, Famularo G, Steinberg SM, Boschini A, Cifone MG, De Simone C.

Blood. 1998 May 15;91(10):3817-24.


IFN-α exerts opposing effects on activation-induced and IL-7-induced proliferation of T cells that may impair homeostatic maintenance of CD4+ T cell numbers in treated HIV infection.

Cha L, de Jong E, French MA, Fernandez S.

J Immunol. 2014 Sep 1;193(5):2178-86. doi: 10.4049/jimmunol.1302536. Epub 2014 Jul 25.


Expression of the IL-7 receptor alpha-chain is down regulated on the surface of CD4 T-cells by the HIV-1 Tat protein.

McLaughlin D, Faller E, Sugden S, MacPherson P.

PLoS One. 2014 Oct 21;9(10):e111193. doi: 10.1371/journal.pone.0111193. eCollection 2014.


Altered receptor expression and decreased sensitivity of T-cells to the stimulatory cytokines IL-2, IL-7 and IL-12 in HIV infection.

Vingerhoets J, Bisalinkumi E, Penne G, Colebunders R, Bosmans E, Kestens L, Vanham G.

Immunol Lett. 1998 Mar;61(1):53-61.


Persistent apoptosis in HIV-1-infected individuals receiving potent antiretroviral therapy is associated with poor recovery of CD4 T lymphocytes.

Hansjee N, Kaufmann GR, Strub C, Weber R, Battegay M, Erb P; Swiss HIV Cohort Study.

J Acquir Immune Defic Syndr. 2004 Jun 1;36(2):671-7.


Close association of CD8+/CD38 bright with HIV-1 replication and complex relationship with CD4+ T-cell count.

Tuaillon E, Al Tabaa Y, Baillat V, Segondy M, Picot MC, Reynes J, Vendrell JP.

Cytometry B Clin Cytom. 2009 Jul;76(4):249-60. doi: 10.1002/cyto.b.20467.


The role of interleukin-converting enzyme in Fas-mediated apoptosis in HIV-1 infection.

Sloand EM, Maciejewski JP, Sato T, Bruny J, Kumar P, Kim S, Weichold FF, Young NS.

J Clin Invest. 1998 Jan 1;101(1):195-201.


Type I interferon upregulates Bak and contributes to T cell loss during human immunodeficiency virus (HIV) infection.

Fraietta JA, Mueller YM, Yang G, Boesteanu AC, Gracias DT, Do DH, Hope JL, Kathuria N, McGettigan SE, Lewis MG, Giavedoni LD, Jacobson JM, Katsikis PD.

PLoS Pathog. 2013;9(10):e1003658. doi: 10.1371/journal.ppat.1003658. Epub 2013 Oct 10.


IL-7Ralpha expression on CD4+ T lymphocytes decreases with HIV disease progression and inversely correlates with immune activation.

Koesters SA, Alimonti JB, Wachihi C, Matu L, Anzala O, Kimani J, Embree JE, Plummer FA, Fowke KR.

Eur J Immunol. 2006 Feb;36(2):336-44.


Apoptosis in T-lymphocyte subsets in human immunodeficiency virus-infected children measured immediately ex vivo and following in vitro activation.

Niehues T, McCloskey TW, Ndagijimana J, Horneff G, Wahn V, Pahwa S.

Clin Diagn Lab Immunol. 2001 Jan;8(1):74-8.

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