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Items: 1 to 20 of 109

1.

The p85alpha regulatory subunit of phosphoinositide 3-kinase potentiates c-Jun N-terminal kinase-mediated insulin resistance.

Taniguchi CM, Aleman JO, Ueki K, Luo J, Asano T, Kaneto H, Stephanopoulos G, Cantley LC, Kahn CR.

Mol Cell Biol. 2007 Apr;27(8):2830-40. Epub 2007 Feb 5.

2.

Increased P85alpha is a potent negative regulator of skeletal muscle insulin signaling and induces in vivo insulin resistance associated with growth hormone excess.

Barbour LA, Mizanoor Rahman S, Gurevich I, Leitner JW, Fischer SJ, Roper MD, Knotts TA, Vo Y, McCurdy CE, Yakar S, Leroith D, Kahn CR, Cantley LC, Friedman JE, Draznin B.

J Biol Chem. 2005 Nov 11;280(45):37489-94. Epub 2005 Sep 8.

3.

Palmitate induces insulin resistance in H4IIEC3 hepatocytes through reactive oxygen species produced by mitochondria.

Nakamura S, Takamura T, Matsuzawa-Nagata N, Takayama H, Misu H, Noda H, Nabemoto S, Kurita S, Ota T, Ando H, Miyamoto K, Kaneko S.

J Biol Chem. 2009 May 29;284(22):14809-18. doi: 10.1074/jbc.M901488200. Epub 2009 Mar 30.

4.

Reduced expression of the murine p85alpha subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes.

Mauvais-Jarvis F, Ueki K, Fruman DA, Hirshman MF, Sakamoto K, Goodyear LJ, Iannacone M, Accili D, Cantley LC, Kahn CR.

J Clin Invest. 2002 Jan;109(1):141-9.

5.

Role of the liver in glucose homeostasis in PI 3-kinase p85alpha-deficient mice.

Aoki K, Matsui J, Kubota N, Nakajima H, Iwamoto K, Takamoto I, Tsuji Y, Ohno A, Mori S, Tokuyama K, Murakami K, Asano T, Aizawa S, Tobe K, Kadowaki T, Terauchi Y.

Am J Physiol Endocrinol Metab. 2009 Apr;296(4):E842-53. doi: 10.1152/ajpendo.90528.2008. Epub 2009 Jan 27.

7.

Protein tyrosine phosphatase 1B and insulin resistance: role of endoplasmic reticulum stress/reactive oxygen species/nuclear factor kappa B axis.

Panzhinskiy E, Ren J, Nair S.

PLoS One. 2013 Oct 18;8(10):e77228. doi: 10.1371/journal.pone.0077228. eCollection 2013.

8.

Inflammation and endoplasmic reticulum stress in obesity and diabetes.

Hotamisligil GS.

Int J Obes (Lond). 2008 Dec;32 Suppl 7:S52-4. doi: 10.1038/ijo.2008.238. Review.

9.

Role of phosphoinositide 3-kinase regulatory isoforms in development and actin rearrangement.

Brachmann SM, Yballe CM, Innocenti M, Deane JA, Fruman DA, Thomas SM, Cantley LC.

Mol Cell Biol. 2005 Apr;25(7):2593-606.

10.

Phosphoinositide 3-kinase regulatory subunit p85alpha suppresses insulin action via positive regulation of PTEN.

Taniguchi CM, Tran TT, Kondo T, Luo J, Ueki K, Cantley LC, Kahn CR.

Proc Natl Acad Sci U S A. 2006 Aug 8;103(32):12093-7. Epub 2006 Jul 31. Erratum in: Proc Natl Acad Sci U S A. 2016 Jun 21;113(25):E3588.

11.

The Ras/Rac1/Cdc42/SEK/JNK/c-Jun cascade is a key pathway by which agonists stimulate DNA synthesis in primary cultures of rat hepatocytes.

Auer KL, Contessa J, Brenz-Verca S, Pirola L, Rusconi S, Cooper G, Abo A, Wymann MP, Davis RJ, Birrer M, Dent P.

Mol Biol Cell. 1998 Mar;9(3):561-73.

12.

A PI3K activity-independent function of p85 regulatory subunit in control of mammalian cytokinesis.

García Z, Silio V, Marqués M, Cortés I, Kumar A, Hernandez C, Checa AI, Serrano A, Carrera AC.

EMBO J. 2006 Oct 18;25(20):4740-51. Epub 2006 Oct 5.

13.

Resveratrol induces FasL-related apoptosis through Cdc42 activation of ASK1/JNK-dependent signaling pathway in human leukemia HL-60 cells.

Su JL, Lin MT, Hong CC, Chang CC, Shiah SG, Wu CW, Chen ST, Chau YP, Kuo ML.

Carcinogenesis. 2005 Jan;26(1):1-10. Epub 2004 Jun 24.

PMID:
15217905
14.

Direct positive regulation of PTEN by the p85 subunit of phosphatidylinositol 3-kinase.

Chagpar RB, Links PH, Pastor MC, Furber LA, Hawrysh AD, Chamberlain MD, Anderson DH.

Proc Natl Acad Sci U S A. 2010 Mar 23;107(12):5471-6. doi: 10.1073/pnas.0908899107. Epub 2010 Mar 8.

15.

Requirement of JIP1-mediated c-Jun N-terminal kinase activation for obesity-induced insulin resistance.

Morel C, Standen CL, Jung DY, Gray S, Ong H, Flavell RA, Kim JK, Davis RJ.

Mol Cell Biol. 2010 Oct;30(19):4616-25. doi: 10.1128/MCB.00585-10. Epub 2010 Aug 2.

16.

Mitochondrial dysfunction in insulin resistance: differential contributions of chronic insulin and saturated fatty acid exposure in muscle cells.

Yang C, Aye CC, Li X, Diaz Ramos A, Zorzano A, Mora S.

Biosci Rep. 2012 Oct;32(5):465-78. doi: 10.1042/BSR20120034.

17.
18.

Increased insulin sensitivity in mice lacking p85beta subunit of phosphoinositide 3-kinase.

Ueki K, Yballe CM, Brachmann SM, Vicent D, Watt JM, Kahn CR, Cantley LC.

Proc Natl Acad Sci U S A. 2002 Jan 8;99(1):419-24. Epub 2001 Dec 18.

19.

Emerging role of JNK in insulin resistance.

Li H, Yu X.

Curr Diabetes Rev. 2013 Sep;9(5):422-8. Review.

PMID:
23865415
20.

c-Jun N-terminal kinase pathways in diabetes.

Yang R, Trevillyan JM.

Int J Biochem Cell Biol. 2008;40(12):2702-6. doi: 10.1016/j.biocel.2008.06.012. Epub 2008 Jul 17. Review.

PMID:
18678273

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