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Items: 1 to 20 of 218

1.

STAT3 is required for IL-6-gp130-dependent activation of hepcidin in vivo.

Pietrangelo A, Dierssen U, Valli L, Garuti C, Rump A, Corradini E, Ernst M, Klein C, Trautwein C.

Gastroenterology. 2007 Jan;132(1):294-300. Epub 2006 Oct 17. Erratum in: Gastroenterology. 2007 Mar;132(3):1208.

PMID:
17241879
2.

Molecular dissection of gp130-dependent pathways in hepatocytes during liver regeneration.

Dierssen U, Beraza N, Lutz HH, Liedtke C, Ernst M, Wasmuth HE, Trautwein C.

J Biol Chem. 2008 Apr 11;283(15):9886-95. doi: 10.1074/jbc.M705483200. Epub 2008 Jan 23.

3.

STAT3 and STAT1 mediate IL-11-dependent and inflammation-associated gastric tumorigenesis in gp130 receptor mutant mice.

Ernst M, Najdovska M, Grail D, Lundgren-May T, Buchert M, Tye H, Matthews VB, Armes J, Bhathal PS, Hughes NR, Marcusson EG, Karras JG, Na S, Sedgwick JD, Hertzog PJ, Jenkins BJ.

J Clin Invest. 2008 May;118(5):1727-38. doi: 10.1172/JCI34944.

4.

Hyperactivation of Stat3 in gp130 mutant mice promotes gastric hyperproliferation and desensitizes TGF-beta signaling.

Jenkins BJ, Grail D, Nheu T, Najdovska M, Wang B, Waring P, Inglese M, McLoughlin RM, Jones SA, Topley N, Baumann H, Judd LM, Giraud AS, Boussioutas A, Zhu HJ, Ernst M.

Nat Med. 2005 Aug;11(8):845-52. Epub 2005 Jul 24.

PMID:
16041381
5.

IL-6 regulates neutrophil trafficking during acute inflammation via STAT3.

Fielding CA, McLoughlin RM, McLeod L, Colmont CS, Najdovska M, Grail D, Ernst M, Jones SA, Topley N, Jenkins BJ.

J Immunol. 2008 Aug 1;181(3):2189-95.

6.

Pathologic consequences of STAT3 hyperactivation by IL-6 and IL-11 during hematopoiesis and lymphopoiesis.

Jenkins BJ, Roberts AW, Greenhill CJ, Najdovska M, Lundgren-May T, Robb L, Grail D, Ernst M.

Blood. 2007 Mar 15;109(6):2380-8. Epub 2006 Nov 2.

7.

The IL-6-gp130-STAT3 pathway in hepatocytes triggers liver protection in T cell-mediated liver injury.

Klein C, Wüstefeld T, Assmus U, Roskams T, Rose-John S, Müller M, Manns MP, Ernst M, Trautwein C.

J Clin Invest. 2005 Apr;115(4):860-9. Epub 2005 Mar 3.

8.

Continuous glycoprotein-130-mediated signal transducer and activator of transcription-3 activation promotes inflammation, left ventricular rupture, and adverse outcome in subacute myocardial infarction.

Hilfiker-Kleiner D, Shukla P, Klein G, Schaefer A, Stapel B, Hoch M, Müller W, Scherr M, Theilmeier G, Ernst M, Hilfiker A, Drexler H.

Circulation. 2010 Jul 13;122(2):145-55. doi: 10.1161/CIRCULATIONAHA.109.933127. Epub 2010 Jun 28.

9.

Opposing roles of gp130-mediated STAT-3 and ERK-1/ 2 signaling in liver progenitor cell migration and proliferation.

Yeoh GC, Ernst M, Rose-John S, Akhurst B, Payne C, Long S, Alexander W, Croker B, Grail D, Matthews VB.

Hepatology. 2007 Feb;45(2):486-94.

PMID:
17256754
10.

The peroxisome proliferator-activated receptor (PPAR) β/δ agonist GW501516 inhibits IL-6-induced signal transducer and activator of transcription 3 (STAT3) activation and insulin resistance in human liver cells.

Serrano-Marco L, Barroso E, El Kochairi I, Palomer X, Michalik L, Wahli W, Vázquez-Carrera M.

Diabetologia. 2012 Mar;55(3):743-51. doi: 10.1007/s00125-011-2401-4. Epub 2011 Dec 17.

PMID:
22179221
12.

Pretreatment with CO-releasing molecules suppresses hepcidin expression during inflammation and endoplasmic reticulum stress through inhibition of the STAT3 and CREBH pathways.

Shin DY, Chung J, Joe Y, Pae HO, Chang KC, Cho GJ, Ryter SW, Chung HT.

Blood. 2012 Mar 15;119(11):2523-32. doi: 10.1182/blood-2011-07-366690. Epub 2012 Jan 19.

13.

The threshold of gp130-dependent STAT3 signaling is critical for normal regulation of hematopoiesis.

Jenkins BJ, Roberts AW, Najdovska M, Grail D, Ernst M.

Blood. 2005 May 1;105(9):3512-20. Epub 2005 Jan 13.

14.

Sustained submicromolar H2O2 levels induce hepcidin via signal transducer and activator of transcription 3 (STAT3).

Millonig G, Ganzleben I, Peccerella T, Casanovas G, Brodziak-Jarosz L, Breitkopf-Heinlein K, Dick TP, Seitz HK, Muckenthaler MU, Mueller S.

J Biol Chem. 2012 Oct 26;287(44):37472-82. doi: 10.1074/jbc.M112.358911. Epub 2012 Aug 29.

15.

Critical and independent role for SOCS3 in either myeloid or T cells in resistance to Mycobacterium tuberculosis.

Carow B, Reuschl AK, Gavier-Widén D, Jenkins BJ, Ernst M, Yoshimura A, Chambers BJ, Rottenberg ME.

PLoS Pathog. 2013;9(7):e1003442. doi: 10.1371/journal.ppat.1003442. Epub 2013 Jul 4.

16.

Imbalanced gp130-dependent signaling in macrophages alters macrophage colony-stimulating factor responsiveness via regulation of c-fms expression.

Jenkins BJ, Grail D, Inglese M, Quilici C, Bozinovski S, Wong P, Ernst M.

Mol Cell Biol. 2004 Feb;24(4):1453-63.

17.

STAT3 activation in response to IL-6 is prolonged by the binding of IL-6 receptor to EGF receptor.

Wang Y, van Boxel-Dezaire AH, Cheon H, Yang J, Stark GR.

Proc Natl Acad Sci U S A. 2013 Oct 15;110(42):16975-80. doi: 10.1073/pnas.1315862110. Epub 2013 Sep 30.

18.

Iron-regulatory gene expression during liver regeneration.

Mollbrink A, Holmström P, Sjöström M, Hultcrantz R, Eriksson LC, Stål P.

Scand J Gastroenterol. 2012 May;47(5):591-600. doi: 10.3109/00365521.2012.661761. Epub 2012 Feb 27.

PMID:
22364558
19.

Bile acids inhibit interleukin-6 signaling via gp130 receptor-dependent and -independent pathways in rat liver.

Graf D, Kohlmann C, Haselow K, Gehrmann T, Bode JG, Häussinger D.

Hepatology. 2006 Nov;44(5):1206-17.

PMID:
17058237
20.

IL-6-gp130-STAT3 in T cells directs the development of IL-17+ Th with a minimum effect on that of Treg in the steady state.

Nishihara M, Ogura H, Ueda N, Tsuruoka M, Kitabayashi C, Tsuji F, Aono H, Ishihara K, Huseby E, Betz UA, Murakami M, Hirano T.

Int Immunol. 2007 Jun;19(6):695-702. Epub 2007 May 9.

PMID:
17493959

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