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The APC/C inhibitor, Emi1, is essential for prevention of rereplication.

Machida YJ, Dutta A.

Genes Dev. 2007 Jan 15;21(2):184-94.


Role of Polo-like kinase in the degradation of early mitotic inhibitor 1, a regulator of the anaphase promoting complex/cyclosome.

Moshe Y, Boulaire J, Pagano M, Hershko A.

Proc Natl Acad Sci U S A. 2004 May 25;101(21):7937-42. Epub 2004 May 17.


Regulation of the action of early mitotic inhibitor 1 on the anaphase-promoting complex/cyclosome by cyclin-dependent kinases.

Moshe Y, Bar-On O, Ganoth D, Hershko A.

J Biol Chem. 2011 May 13;286(19):16647-57. doi: 10.1074/jbc.M111.223339. Epub 2011 Mar 16.


The evi5 oncogene regulates cyclin accumulation by stabilizing the anaphase-promoting complex inhibitor emi1.

Eldridge AG, Loktev AV, Hansen DV, Verschuren EW, Reimann JD, Jackson PK.

Cell. 2006 Jan 27;124(2):367-80.


Dual regulation of the anaphase promoting complex in human cells by cyclin A-Cdk2 and cyclin A-Cdk1 complexes.

Mitra J, Enders GH, Azizkhan-Clifford J, Lengel KL.

Cell Cycle. 2006 Mar;5(6):661-6. Epub 2006 Mar 15.


Rereplication in emi1-deficient zebrafish embryos occurs through a Cdh1-mediated pathway.

Robu ME, Zhang Y, Rhodes J.

PLoS One. 2012;7(10):e47658. doi: 10.1371/journal.pone.0047658. Epub 2012 Oct 17.


Early mitotic inhibitor-1, an anaphase-promoting complex/cyclosome inhibitor, can control tumor cell proliferation in hepatocellular carcinoma: correlation with Skp2 stability and degradation of p27(Kip1).

Zhao Y, Tang Q, Ni R, Huang X, Wang Y, Lu C, Shen A, Wang Y, Li C, Yuan Q, Chen H, Cheng C, He S.

Hum Pathol. 2013 Mar;44(3):365-73. doi: 10.1016/j.humpath.2012.03.030. Epub 2012 Sep 17.


The END network couples spindle pole assembly to inhibition of the anaphase-promoting complex/cyclosome in early mitosis.

Ban KH, Torres JZ, Miller JJ, Mikhailov A, Nachury MV, Tung JJ, Rieder CL, Jackson PK.

Dev Cell. 2007 Jul;13(1):29-42.


Emi1 is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex.

Reimann JD, Freed E, Hsu JY, Kramer ER, Peters JM, Jackson PK.

Cell. 2001 Jun 1;105(5):645-55.


The anaphase-promoting complex/cyclosome (APC/C) is required for rereplication control in endoreplication cycles.

Zielke N, Querings S, Rottig C, Lehner C, Sprenger F.

Genes Dev. 2008 Jun 15;22(12):1690-703. doi: 10.1101/gad.469108.


DNA damage triggers p21WAF1-dependent Emi1 down-regulation that maintains G2 arrest.

Lee J, Kim JA, Barbier V, Fotedar A, Fotedar R.

Mol Biol Cell. 2009 Apr;20(7):1891-902. doi: 10.1091/mbc.E08-08-0818. Epub 2009 Feb 11.


Emi1 stably binds and inhibits the anaphase-promoting complex/cyclosome as a pseudosubstrate inhibitor.

Miller JJ, Summers MK, Hansen DV, Nachury MV, Lehman NL, Loktev A, Jackson PK.

Genes Dev. 2006 Sep 1;20(17):2410-20. Epub 2006 Aug 18.


Defining the role of Emi1 in the DNA replication-segregation cycle.

Di Fiore B, Pines J.

Chromosoma. 2008 Aug;117(4):333-8. doi: 10.1007/s00412-008-0152-x. Epub 2008 Mar 4. Review.


The APC/C inhibitor XErp1/Emi2 is essential for Xenopus early embryonic divisions.

Tischer T, Hörmanseder E, Mayer TU.

Science. 2012 Oct 26;338(6106):520-4. doi: 10.1126/science.1228394. Epub 2012 Sep 27.


Emi1 regulates the anaphase-promoting complex by a different mechanism than Mad2 proteins.

Reimann JD, Gardner BE, Margottin-Goguet F, Jackson PK.

Genes Dev. 2001 Dec 15;15(24):3278-85.


A role for the anaphase-promoting complex inhibitor Emi2/XErp1, a homolog of early mitotic inhibitor 1, in cytostatic factor arrest of Xenopus eggs.

Tung JJ, Hansen DV, Ban KH, Loktev AV, Summers MK, Adler JR 3rd, Jackson PK.

Proc Natl Acad Sci U S A. 2005 Mar 22;102(12):4318-23. Epub 2005 Mar 7.

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