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Nutlin3 blocks vascular endothelial growth factor induction by preventing the interaction between hypoxia inducible factor 1alpha and Hdm2.

LaRusch GA, Jackson MW, Dunbar JD, Warren RS, Donner DB, Mayo LD.

Cancer Res. 2007 Jan 15;67(2):450-4.


Nutlin-3, an Hdm2 antagonist, inhibits tumor adaptation to hypoxia by stimulating the FIH-mediated inactivation of HIF-1alpha.

Lee YM, Lim JH, Chun YS, Moon HE, Lee MK, Huang LE, Park JW.

Carcinogenesis. 2009 Oct;30(10):1768-75. doi: 10.1093/carcin/bgp196. Epub 2009 Aug 20.


Effect of MDM2 and vascular endothelial growth factor inhibition on tumor angiogenesis and metastasis in neuroblastoma.

Patterson DM, Gao D, Trahan DN, Johnson BA, Ludwig A, Barbieri E, Chen Z, Diaz-Miron J, Vassilev L, Shohet JM, Kim ES.

Angiogenesis. 2011 Sep;14(3):255-66. doi: 10.1007/s10456-011-9210-8. Epub 2011 Apr 12.


A novel regulation of VEGF expression by HIF-1α and STAT3 in HDM2 transfected prostate cancer cells.

Rathinavelu A, Narasimhan M, Muthumani P.

J Cell Mol Med. 2012 Aug;16(8):1750-7. doi: 10.1111/j.1582-4934.2011.01472.x.


HDM2 antagonist Nutlin-3 disrupts p73-HDM2 binding and enhances p73 function.

Lau LM, Nugent JK, Zhao X, Irwin MS.

Oncogene. 2008 Feb 7;27(7):997-1003. Epub 2007 Aug 13.


Small-molecule activation of p53 blocks hypoxia-inducible factor 1alpha and vascular endothelial growth factor expression in vivo and leads to tumor cell apoptosis in normoxia and hypoxia.

Yang J, Ahmed A, Poon E, Perusinghe N, de Haven Brandon A, Box G, Valenti M, Eccles S, Rouschop K, Wouters B, Ashcroft M.

Mol Cell Biol. 2009 Apr;29(8):2243-53. doi: 10.1128/MCB.00959-08. Epub 2009 Feb 17.


Detection of HDM2 and VEGF co-expression in cancer cell lines: novel effect of HDM2 antisense treatment on VEGF expression.

Narasimhan M, Rose R, Karthikeyan M, Rathinavelu A.

Life Sci. 2007 Oct 13;81(17-18):1362-72. Epub 2007 Sep 9.


Apigenin inhibits VEGF and HIF-1 expression via PI3K/AKT/p70S6K1 and HDM2/p53 pathways.

Fang J, Xia C, Cao Z, Zheng JZ, Reed E, Jiang BH.

FASEB J. 2005 Mar;19(3):342-53.


Levels of HdmX expression dictate the sensitivity of normal and transformed cells to Nutlin-3.

Patton JT, Mayo LD, Singhi AD, Gudkov AV, Stark GR, Jackson MW.

Cancer Res. 2006 Mar 15;66(6):3169-76.


HDM2 antagonist MI-219 (spiro-oxindole), but not Nutlin-3 (cis-imidazoline), regulates p53 through enhanced HDM2 autoubiquitination and degradation in human malignant B-cell lymphomas.

Sosin AM, Burger AM, Siddiqi A, Abrams J, Mohammad RM, Al-Katib AM.

J Hematol Oncol. 2012 Sep 18;5:57. doi: 10.1186/1756-8722-5-57.


Serdemetan antagonizes the Mdm2-HIF1α axis leading to decreased levels of glycolytic enzymes.

Lehman JA, Hauck PM, Gendron JM, Batuello CN, Eitel JA, Albig A, Kadakia MP, Mayo LD.

PLoS One. 2013 Sep 6;8(9):e74741. doi: 10.1371/journal.pone.0074741. eCollection 2013.


Analysis of hypoxia-related gene expression in sarcomas and effect of hypoxia on RNA interference of vascular endothelial cell growth factor A.

Detwiller KY, Fernando NT, Segal NH, Ryeom SW, D'Amore PA, Yoon SS.

Cancer Res. 2005 Jul 1;65(13):5881-9.


A regulatory loop composed of RAP80-HDM2-p53 provides RAP80-enhanced p53 degradation by HDM2 in response to DNA damage.

Yan J, Menendez D, Yang XP, Resnick MA, Jetten AM.

J Biol Chem. 2009 Jul 17;284(29):19280-9. doi: 10.1074/jbc.M109.013102. Epub 2009 May 11.


Reactivation of p53 function in synovial sarcoma cells by inhibition of p53-HDM2 interaction.

D'Arcy P, Ryan BA, Brodin B.

Cancer Lett. 2009 Mar 18;275(2):285-92. doi: 10.1016/j.canlet.2008.10.030. Epub 2008 Dec 9.


Ras homolog gene family, member A promotes p53 degradation and vascular endothelial growth factor-dependent angiogenesis through an interaction with murine double minute 2 under hypoxic conditions.

Ma J, Xue Y, Cui W, Li Y, Zhao Q, Ye W, Zheng J, Cheng Y, Ma Y, Li S, Han T, Miao L, Yao L, Zhang J, Liu W.

Cancer. 2012 Sep 1;118(17):4105-16. doi: 10.1002/cncr.27393. Epub 2012 Jan 3. Erratum in: Cancer. 2015 Feb 1;121(3):485.


Protein phosphatase 1 nuclear targeting subunit is a hypoxia inducible gene: its role in post-translational modification of p53 and MDM2.

Lee SJ, Lim CJ, Min JK, Lee JK, Kim YM, Lee JY, Won MH, Kwon YG.

Cell Death Differ. 2007 Jun;14(6):1106-16. Epub 2007 Feb 23.


Reactive oxygen species regulate FSH-induced expression of vascular endothelial growth factor via Nrf2 and HIF1α signaling in human epithelial ovarian cancer.

Zhang Z, Wang Q, Ma J, Yi X, Zhu Y, Xi X, Feng Y, Jin Z.

Oncol Rep. 2013 Apr;29(4):1429-34. doi: 10.3892/or.2013.2278. Epub 2013 Feb 6.


Binding of Translationally Controlled Tumour Protein to the N-terminal domain of HDM2 is inhibited by nutlin-3.

Funston G, Goh W, Wei SJ, Tng QS, Brown C, Jiah Tong L, Verma C, Lane D, Ghadessy F.

PLoS One. 2012;7(8):e42642. doi: 10.1371/journal.pone.0042642. Epub 2012 Aug 13.

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