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EGCG, a green tea polyphenol, improves endothelial function and insulin sensitivity, reduces blood pressure, and protects against myocardial I/R injury in SHR.

Potenza MA, Marasciulo FL, Tarquinio M, Tiravanti E, Colantuono G, Federici A, Kim JA, Quon MJ, Montagnani M.

Am J Physiol Endocrinol Metab. 2007 May;292(5):E1378-87. Epub 2007 Jan 16.


Epigallocatechin gallate, a green tea polyphenol, mediates NO-dependent vasodilation using signaling pathways in vascular endothelium requiring reactive oxygen species and Fyn.

Kim JA, Formoso G, Li Y, Potenza MA, Marasciulo FL, Montagnani M, Quon MJ.

J Biol Chem. 2007 May 4;282(18):13736-45. Epub 2007 Mar 15.


Effects of the green tea polyphenol epigallocatechin-3-gallate on high-fat diet-induced insulin resistance and endothelial dysfunction.

Jang HJ, Ridgeway SD, Kim JA.

Am J Physiol Endocrinol Metab. 2013 Dec;305(12):E1444-51. doi: 10.1152/ajpendo.00434.2013. Epub 2013 Oct 22.


Insulin resistance in spontaneously hypertensive rats is associated with endothelial dysfunction characterized by imbalance between NO and ET-1 production.

Potenza MA, Marasciulo FL, Chieppa DM, Brigiani GS, Formoso G, Quon MJ, Montagnani M.

Am J Physiol Heart Circ Physiol. 2005 Aug;289(2):H813-22. Epub 2005 Mar 25.


Combination of low-dose valsartan and enalapril improves endothelial dysfunction and coronary reserve in Nomega-nitro-L-arginine methyl ester-treated spontaneously hypertensive rats.

de Gasparo M, Hess P, Clozel M, Persohn E, Roman D, Germann PG, Clozel JP, Webb RL.

J Cardiovasc Pharmacol. 2002 Nov;40(5):789-800.


Angiotensin-converting enzyme inhibition and angiotensin AT1-receptor antagonism equally improve endothelial vasodilator function in L-NAME-induced hypertensive rats.

De Gennaro Colonna V, Rigamonti A, Fioretti S, Bonomo S, Manfredi B, Ferrario P, Bianchi M, Berti F, Muller EE, Rossoni G.

Eur J Pharmacol. 2005 Jun 15;516(3):253-9.


Abnormal renal medullary response to angiotensin II in SHR is corrected by long-term enalapril treatment.

Dukacz SA, Feng MG, Yang LF, Lee RM, Kline RL.

Am J Physiol Regul Integr Comp Physiol. 2001 Apr;280(4):R1076-84.


Nitric oxide in mesenteric vascular reactivity: a comparison between rats with normotension and hypertension.

Chang HR, Lee RP, Wu CY, Chen HI.

Clin Exp Pharmacol Physiol. 2002 Apr;29(4):275-80.


Angiotensin-(1-7) blockade attenuates captopril- or hydralazine-induced cardiovascular protection in spontaneously hypertensive rats treated with NG-nitro-L-arginine methyl ester.

Benter IF, Yousif MH, Al-Saleh FM, Raghupathy R, Chappell MC, Diz DI.

J Cardiovasc Pharmacol. 2011 May;57(5):559-67. doi: 10.1097/FJC.0b013e31821324b6.


Acute vascular and metabolic actions of the green tea polyphenol epigallocatechin 3-gallate in rat skeletal muscle.

Ng HL, Premilovac D, Rattigan S, Richards SM, Muniyappa R, Quon MJ, Keske MA.

J Nutr Biochem. 2017 Feb;40:23-31. doi: 10.1016/j.jnutbio.2016.10.005. Epub 2016 Oct 14.


Enalapril and quinapril improve endothelial vasodilator function and aortic eNOS gene expression in L-NAME-treated rats.

De Gennaro Colonna V, Rossoni G, Rigamonti A, Bonomo S, Manfredi B, Berti F, Muller E.

Eur J Pharmacol. 2002 Aug 16;450(1):61-6.


Treatment with an extract of Terminalia superba Engler & Diels decreases blood pressure and improves endothelial function in spontaneously hypertensive rats.

Tom EN, Girard-Thernier C, Martin H, Dimo T, Alvergnas M, Nappey M, Berthelot A, Demougeot C.

J Ethnopharmacol. 2014;151(1):372-9. doi: 10.1016/j.jep.2013.10.057. Epub 2013 Nov 7.


Sildenafil reduces L-NAME-induced severe hypertension and worsening of myocardial ischaemia-reperfusion damage in the rat.

Rossoni G, Manfredi B, De Gennaro Colonna V, Berti M, Guazzi M, Berti F.

Br J Pharmacol. 2007 Mar;150(5):567-76. Epub 2007 Jan 22.


KCa 3.1 channels maintain endothelium-dependent vasodilatation in isolated perfused kidneys of spontaneously hypertensive rats after chronic inhibition of NOS.

Simonet S, Isabelle M, Bousquenaud M, Clavreul N, Félétou M, Vayssettes-Courchay C, Verbeuren TJ.

Br J Pharmacol. 2012 Oct;167(4):854-67. doi: 10.1111/j.1476-5381.2012.02062.x.


Treatment of spontaneously hypertensive rats with rosiglitazone ameliorates cardiovascular pathophysiology via antioxidant mechanisms in the vasculature.

Potenza MA, Gagliardi S, De Benedictis L, Zigrino A, Tiravanti E, Colantuono G, Federici A, Lorusso L, Benagiano V, Quon MJ, Montagnani M.

Am J Physiol Endocrinol Metab. 2009 Sep;297(3):E685-94. doi: 10.1152/ajpendo.00291.2009. Epub 2009 Jun 16.


Chronic treatment with epigallocatechin gallate reduces motor hyperactivity and affects in vitro tested intestinal motility of spontaneously hypertensive rats.

Potenza MA, Montagnani M, Nacci C, De Salvia MA.

Food Nutr Res. 2016 Feb 17;60:28373. doi: 10.3402/fnr.v60.28373. eCollection 2016.


Alpha-lactorphin and beta-lactorphin improve arterial function in spontaneously hypertensive rats.

Sipola M, Finckenberg P, Vapaatalo H, Pihlanto-Leppälä A, Korhonen H, Korpela R, Nurminen ML.

Life Sci. 2002 Aug 2;71(11):1245-53.


Vasorelaxant effects of the chronic treatment with melatonin on mesenteric artery and aorta of spontaneously hypertensive rats.

Girouard H, Chulak C, Lejossec M, Lamontagne D, de Champlain J.

J Hypertens. 2001 Aug;19(8):1369-77.


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