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Items: 1 to 20 of 100

1.
2.

Ligand selectivity and affinity of chemokine receptor CXCR1. Role of N-terminal domain.

Rajagopalan L, Rajarathnam K.

J Biol Chem. 2004 Jul 16;279(29):30000-8. Epub 2004 May 7.

3.

Structural basis for differential binding of the interleukin-8 monomer and dimer to the CXCR1 N-domain: role of coupled interactions and dynamics.

Ravindran A, Joseph PR, Rajarathnam K.

Biochemistry. 2009 Sep 22;48(37):8795-805. doi: 10.1021/bi901194p.

4.

Dimer dissociation is essential for interleukin-8 (IL-8) binding to CXCR1 receptor.

Fernando H, Chin C, Rösgen J, Rajarathnam K.

J Biol Chem. 2004 Aug 27;279(35):36175-8. Epub 2004 Jul 12.

5.

Solution NMR characterization of WT CXCL8 monomer and dimer binding to CXCR1 N-terminal domain.

Joseph PR, Rajarathnam K.

Protein Sci. 2015 Jan;24(1):81-92. doi: 10.1002/pro.2590. Epub 2014 Nov 28.

6.

Probing receptor binding activity of interleukin-8 dimer using a disulfide trap.

Rajarathnam K, Prado GN, Fernando H, Clark-Lewis I, Navarro J.

Biochemistry. 2006 Jun 27;45(25):7882-8.

7.

Synergistic interactions between chemokine receptor elements in recognition of interleukin-8 by soluble receptor mimics.

Barter EF, Stone MJ.

Biochemistry. 2012 Feb 14;51(6):1322-31. doi: 10.1021/bi201615y. Epub 2012 Jan 30.

8.

Novel use of an osmolyte to dissect multiple thermodynamic linkages in a chemokine ligand-receptor system.

Rajagopalan L, Rösgen J, Bolen DW, Rajarathnam K.

Biochemistry. 2005 Oct 4;44(39):12932-9.

PMID:
16185062
9.

In silico analysis reveals sequential interactions and protein conformational changes during the binding of chemokine CXCL-8 to its receptor CXCR1.

Liou JW, Chang FT, Chung Y, Chen WY, Fischer WB, Hsu HJ.

PLoS One. 2014 Apr 4;9(4):e94178. doi: 10.1371/journal.pone.0094178. eCollection 2014.

10.

The dynamics of interleukin-8 and its interaction with human CXC receptor I peptide.

Kendrick AA, Holliday MJ, Isern NG, Zhang F, Camilloni C, Huynh C, Vendruscolo M, Armstrong G, Eisenmesser EZ.

Protein Sci. 2014 Apr;23(4):464-80. doi: 10.1002/pro.2430. Epub 2014 Feb 12.

11.

Dynamic conformational switching in the chemokine ligand is essential for G-protein-coupled receptor activation.

Joseph PR, Sawant KV, Isley A, Pedroza M, Garofalo RP, Richardson RM, Rajarathnam K.

Biochem J. 2013 Dec 1;456(2):241-51. doi: 10.1042/BJ20130148.

12.

Probing the role of CXC motif in chemokine CXCL8 for high affinity binding and activation of CXCR1 and CXCR2 receptors.

Joseph PR, Sarmiento JM, Mishra AK, Das ST, Garofalo RP, Navarro J, Rajarathnam K.

J Biol Chem. 2010 Sep 17;285(38):29262-9. doi: 10.1074/jbc.M110.146555. Epub 2010 Jul 14.

13.

Structure of the chemokine receptor CXCR1 in phospholipid bilayers.

Park SH, Das BB, Casagrande F, Tian Y, Nothnagel HJ, Chu M, Kiefer H, Maier K, De Angelis AA, Marassi FM, Opella SJ.

Nature. 2012 Nov 29;491(7426):779-83. doi: 10.1038/nature11580. Epub 2012 Oct 21.

14.

Organization and dynamics of the N-terminal domain of chemokine receptor CXCR1 in reverse micelles: effect of graded hydration.

Chaudhuri A, Basu P, Haldar S, Kombrabail M, Krishnamoorthy G, Rajarathnam K, Chattopadhyay A.

J Phys Chem B. 2013 Feb 7;117(5):1225-33. doi: 10.1021/jp3095352. Epub 2013 Jan 28.

15.

Peptides derived from CXCL8 based on in silico analysis inhibit CXCL8 interactions with its receptor CXCR1.

Jiang SJ, Liou JW, Chang CC, Chung Y, Lin LF, Hsu HJ.

Sci Rep. 2015 Dec 22;5:18638. doi: 10.1038/srep18638.

16.

Membrane interaction of the N-terminal domain of chemokine receptor CXCR1.

Haldar S, Raghuraman H, Namani T, Rajarathnam K, Chattopadhyay A.

Biochim Biophys Acta. 2010 Jun;1798(6):1056-61. doi: 10.1016/j.bbamem.2010.02.029. Epub 2010 Mar 11.

17.

Discrete steps in binding and signaling of interleukin-8 with its receptor.

Wu L, Ruffing N, Shi X, Newman W, Soler D, Mackay CR, Qin S.

J Biol Chem. 1996 Dec 6;271(49):31202-9.

18.

Receptor recognition and specificity of interleukin-8 is determined by residues that cluster near a surface-accessible hydrophobic pocket.

Hammond ME, Shyamala V, Siani MA, Gallegos CA, Feucht PH, Abbott J, Lapointe GR, Moghadam M, Khoja H, Zakel J, Tekamp-Olson P.

J Biol Chem. 1996 Apr 5;271(14):8228-35.

19.

Interactions of interleukin-8 with the human chemokine receptor CXCR1 in phospholipid bilayers by NMR spectroscopy.

Park SH, Casagrande F, Cho L, Albrecht L, Opella SJ.

J Mol Biol. 2011 Nov 25;414(2):194-203. doi: 10.1016/j.jmb.2011.08.025. Epub 2011 Oct 12.

20.

The N terminus of interleukin-8 (IL-8) receptor confers high affinity binding to human IL-8.

Suzuki H, Prado GN, Wilkinson N, Navarro J.

J Biol Chem. 1994 Jul 15;269(28):18263-6.

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