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Items: 1 to 20 of 138

1.

Hypothesis: Huntingtin may function in membrane association and vesicular trafficking.

Truant R, Atwal R, Burtnik A.

Biochem Cell Biol. 2006 Dec;84(6):912-7. Review.

PMID:
17215878
2.

Huntingtin-protein interactions and the pathogenesis of Huntington's disease.

Li SH, Li XJ.

Trends Genet. 2004 Mar;20(3):146-54. Review.

PMID:
15036808
3.

Mutant huntingtin interacts with {beta}-tubulin and disrupts vesicular transport and insulin secretion.

Smith R, Bacos K, Fedele V, Soulet D, Walz HA, Obermüller S, Lindqvist A, Björkqvist M, Klein P, Onnerfjord P, Brundin P, Mulder H, Li JY.

Hum Mol Genet. 2009 Oct 15;18(20):3942-54. doi: 10.1093/hmg/ddp336. Epub 2009 Jul 23.

PMID:
19628478
4.

Nucleocytoplasmic trafficking and transcription effects of huntingtin in Huntington's disease.

Truant R, Atwal RS, Burtnik A.

Prog Neurobiol. 2007 Nov;83(4):211-27. Epub 2007 Jan 22. Review.

PMID:
17240517
5.

Huntington's disease: from huntingtin function and dysfunction to therapeutic strategies.

Borrell-Pagès M, Zala D, Humbert S, Saudou F.

Cell Mol Life Sci. 2006 Nov;63(22):2642-60. Review.

PMID:
17041811
6.

Huntingtin as an essential integrator of intracellular vesicular trafficking.

Caviston JP, Holzbaur EL.

Trends Cell Biol. 2009 Apr;19(4):147-55. doi: 10.1016/j.tcb.2009.01.005. Epub 2009 Mar 5. Review.

7.

Molecular aspects of Huntington's disease.

Walling HW, Baldassare JJ, Westfall TC.

J Neurosci Res. 1998 Nov 1;54(3):301-8. Review.

PMID:
9819135
8.

Expansion of polyglutamine repeat in huntingtin leads to abnormal protein interactions involving calmodulin.

Bao J, Sharp AH, Wagster MV, Becher M, Schilling G, Ross CA, Dawson VL, Dawson TM.

Proc Natl Acad Sci U S A. 1996 May 14;93(10):5037-42.

9.

Mutant huntingtin's effects on striatal gene expression in mice recapitulate changes observed in human Huntington's disease brain and do not differ with mutant huntingtin length or wild-type huntingtin dosage.

Kuhn A, Goldstein DR, Hodges A, Strand AD, Sengstag T, Kooperberg C, Becanovic K, Pouladi MA, Sathasivam K, Cha JH, Hannan AJ, Hayden MR, Leavitt BR, Dunnett SB, Ferrante RJ, Albin R, Shelbourne P, Delorenzi M, Augood SJ, Faull RL, Olson JM, Bates GP, Jones L, Luthi-Carter R.

Hum Mol Genet. 2007 Aug 1;16(15):1845-61. Epub 2007 May 21.

PMID:
17519223
10.

Genetic background modifies nuclear mutant huntingtin accumulation and HD CAG repeat instability in Huntington's disease knock-in mice.

Lloret A, Dragileva E, Teed A, Espinola J, Fossale E, Gillis T, Lopez E, Myers RH, MacDonald ME, Wheeler VC.

Hum Mol Genet. 2006 Jun 15;15(12):2015-24. Epub 2006 May 10.

PMID:
16687439
11.

Huntingtin is required for neurogenesis and is not impaired by the Huntington's disease CAG expansion.

White JK, Auerbach W, Duyao MP, Vonsattel JP, Gusella JF, Joyner AL, MacDonald ME.

Nat Genet. 1997 Dec;17(4):404-10.

PMID:
9398841
12.

Huntington's disease: from pathology and genetics to potential therapies.

Imarisio S, Carmichael J, Korolchuk V, Chen CW, Saiki S, Rose C, Krishna G, Davies JE, Ttofi E, Underwood BR, Rubinsztein DC.

Biochem J. 2008 Jun 1;412(2):191-209. doi: 10.1042/BJ20071619. Review.

PMID:
18466116
13.

Live axonal transport disruption by mutant huntingtin fragments in Drosophila motor neuron axons.

Sinadinos C, Burbidge-King T, Soh D, Thompson LM, Marsh JL, Wyttenbach A, Mudher AK.

Neurobiol Dis. 2009 May;34(2):389-95. doi: 10.1016/j.nbd.2009.02.012. Epub 2009 Mar 4.

PMID:
19268537
14.

Huntingtin facilitates polycomb repressive complex 2.

Seong IS, Woda JM, Song JJ, Lloret A, Abeyrathne PD, Woo CJ, Gregory G, Lee JM, Wheeler VC, Walz T, Kingston RE, Gusella JF, Conlon RA, MacDonald ME.

Hum Mol Genet. 2010 Feb 15;19(4):573-83. doi: 10.1093/hmg/ddp524. Epub 2009 Nov 23.

15.

Huntington's disease: From molecular basis to therapeutic advances.

Krobitsch S, Kazantsev AG.

Int J Biochem Cell Biol. 2011 Jan;43(1):20-4. doi: 10.1016/j.biocel.2010.10.014. Epub 2010 Nov 4. Review.

PMID:
21056115
16.

Huntington's disease: new paths to pathogenesis.

Ross CA.

Cell. 2004 Jul 9;118(1):4-7.

17.

[Huntington's disease: intracellular signaling pathways and neuronal death].

Humbert S, Saudou F.

J Soc Biol. 2005;199(3):247-51. Review. French.

PMID:
16471265
18.

Dopamine enhances motor and neuropathological consequences of polyglutamine expanded huntingtin.

Cyr M, Sotnikova TD, Gainetdinov RR, Caron MG.

FASEB J. 2006 Dec;20(14):2541-3. Epub 2006 Oct 25.

PMID:
17065224
19.

[Huntington disease. A review].

Bonilla E.

Invest Clin. 2000 Jun;41(2):117-41. Review. Spanish.

PMID:
10961047
20.

Huntington's disease: how does huntingtin, an anti-apoptotic protein, become toxic?

Rangone H, Humbert S, Saudou F.

Pathol Biol (Paris). 2004 Jul;52(6):338-42. Review.

PMID:
15261377

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