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Mechanisms underlying the resistance to diet-induced obesity in germ-free mice.

Bäckhed F, Manchester JK, Semenkovich CF, Gordon JI.

Proc Natl Acad Sci U S A. 2007 Jan 16;104(3):979-84. Epub 2007 Jan 8.


Effects of alpha-AMPK knockout on exercise-induced gene activation in mouse skeletal muscle.

Jørgensen SB, Wojtaszewski JF, Viollet B, Andreelli F, Birk JB, Hellsten Y, Schjerling P, Vaulont S, Neufer PD, Richter EA, Pilegaard H.

FASEB J. 2005 Jul;19(9):1146-8. Epub 2005 May 5.


The gut microbiota as an environmental factor that regulates fat storage.

Bäckhed F, Ding H, Wang T, Hooper LV, Koh GY, Nagy A, Semenkovich CF, Gordon JI.

Proc Natl Acad Sci U S A. 2004 Nov 2;101(44):15718-23. Epub 2004 Oct 25.


AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha.

Jäger S, Handschin C, St-Pierre J, Spiegelman BM.

Proc Natl Acad Sci U S A. 2007 Jul 17;104(29):12017-22. Epub 2007 Jul 3.


Effects and action mechanisms of berberine and Rhizoma coptidis on gut microbes and obesity in high-fat diet-fed C57BL/6J mice.

Xie W, Gu D, Li J, Cui K, Zhang Y.

PLoS One. 2011;6(9):e24520. doi: 10.1371/journal.pone.0024520. Epub 2011 Sep 6.


Enhanced polyamine catabolism alters homeostatic control of white adipose tissue mass, energy expenditure, and glucose metabolism.

Pirinen E, Kuulasmaa T, Pietilä M, Heikkinen S, Tusa M, Itkonen P, Boman S, Skommer J, Virkamäki A, Hohtola E, Kettunen M, Fatrai S, Kansanen E, Koota S, Niiranen K, Parkkinen J, Levonen AL, Ylä-Herttuala S, Hiltunen JK, Alhonen L, Smith U, Jänne J, Laakso M.

Mol Cell Biol. 2007 Jul;27(13):4953-67. Epub 2007 May 7.


Chronic AMPK activation via loss of FLCN induces functional beige adipose tissue through PGC-1α/ERRα.

Yan M, Audet-Walsh É, Manteghi S, Dufour CR, Walker B, Baba M, St-Pierre J, Giguère V, Pause A.

Genes Dev. 2016 May 1;30(9):1034-46. doi: 10.1101/gad.281410.116.


Monascin and ankaflavin act as natural AMPK activators with PPARα agonist activity to down-regulate nonalcoholic steatohepatitis in high-fat diet-fed C57BL/6 mice.

Hsu WH, Chen TH, Lee BH, Hsu YW, Pan TM.

Food Chem Toxicol. 2014 Feb;64:94-103. doi: 10.1016/j.fct.2013.11.015. Epub 2013 Nov 22.


Metformin increases the PGC-1alpha protein and oxidative enzyme activities possibly via AMPK phosphorylation in skeletal muscle in vivo.

Suwa M, Egashira T, Nakano H, Sasaki H, Kumagai S.

J Appl Physiol (1985). 2006 Dec;101(6):1685-92. Epub 2006 Aug 10.


Cdc2-like kinase 2 suppresses hepatic fatty acid oxidation and ketogenesis through disruption of the PGC-1α and MED1 complex.

Tabata M, Rodgers JT, Hall JA, Lee Y, Jedrychowski MP, Gygi SP, Puigserver P.

Diabetes. 2014 May;63(5):1519-32. doi: 10.2337/db13-1304. Epub 2014 Jan 23.


PGC-1alpha is not mandatory for exercise- and training-induced adaptive gene responses in mouse skeletal muscle.

Leick L, Wojtaszewski JF, Johansen ST, Kiilerich K, Comes G, Hellsten Y, Hidalgo J, Pilegaard H.

Am J Physiol Endocrinol Metab. 2008 Feb;294(2):E463-74. Epub 2007 Dec 11.


The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin.

Shaw RJ, Lamia KA, Vasquez D, Koo SH, Bardeesy N, Depinho RA, Montminy M, Cantley LC.

Science. 2005 Dec 9;310(5754):1642-6. Epub 2005 Nov 24.


Skeletal muscle AMP-activated protein kinase phosphorylation parallels metabolic phenotype in leptin transgenic mice under dietary modification.

Tanaka T, Hidaka S, Masuzaki H, Yasue S, Minokoshi Y, Ebihara K, Chusho H, Ogawa Y, Toyoda T, Sato K, Miyanaga F, Fujimoto M, Tomita T, Kusakabe T, Kobayashi N, Tanioka H, Hayashi T, Hosoda K, Yoshimatsu H, Sakata T, Nakao K.

Diabetes. 2005 Aug;54(8):2365-74.


Absence of intestinal microbiota does not protect mice from diet-induced obesity.

Fleissner CK, Huebel N, Abd El-Bary MM, Loh G, Klaus S, Blaut M.

Br J Nutr. 2010 Sep;104(6):919-29. doi: 10.1017/S0007114510001303. Epub 2010 May 5.


Thyroid hormone (T3) rapidly activates p38 and AMPK in skeletal muscle in vivo.

Irrcher I, Walkinshaw DR, Sheehan TE, Hood DA.

J Appl Physiol (1985). 2008 Jan;104(1):178-85. Epub 2007 Oct 25.


Daytime restricted feeding modifies the daily regulation of fatty acid β-oxidation and the lipoprotein profile in rats.

Rivera-Zavala JB, Molina-Aguilar C, Pérez-Mendoza M, Olguín-Martínez M, Hernández-Muñoz R, Báez-Ruiz GA, Díaz-Muñoz M.

Br J Nutr. 2017 Apr;117(7):930-941. doi: 10.1017/S0007114517000800. Epub 2017 May 9.


Involvement of adenosine monophosphate-activated protein kinase in the influence of timed high-fat evening diet on the hepatic clock and lipogenic gene expression in mice.

Huang Y, Zhu Z, Xie M, Xue J.

Nutr Res. 2015 Sep;35(9):792-9. doi: 10.1016/j.nutres.2015.06.009. Epub 2015 Jun 30.


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