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Items: 1 to 20 of 105

1.

Utilization of achiral alkenyl amines for the preparation of high affinity Grb2 SH2 domain-binding macrocycles by ring-closing metathesis.

Liu F, Worthy KM, Bindu L, Giubellino A, Bottaro DP, Fisher RJ, Burke TR Jr.

Org Biomol Chem. 2007 Jan 21;5(2):367-72. Epub 2006 Dec 4.

PMID:
17205182
3.

Structural examination of ring-closing metathesis-derived 15-member macrocycles as Grb2 SH2 domain-binding tetrapeptide mimetics.

Liu F, Worthy KM, Bindu LK, Fisher RJ, Burke TR Jr.

J Org Chem. 2007 Dec 7;72(25):9635-42. Epub 2007 Nov 9.

4.
5.

Utilization of a common pathway for the synthesis of high affinity macrocyclic Grb2 SH2 domain-binding peptide mimetics that differ in the configuration at one ring junction.

Shi ZD, Karki RG, Worthy KM, Bindu LK, Nicklaus MC, Fisher RJ, Burke TR Jr.

Chem Biodivers. 2005 Apr;2(4):447-56.

PMID:
17191992
6.

Utilization of a beta-aminophosphotyrosyl mimetic in the design and synthesis of macrocyclic Grb2 SH2 domain-binding peptides.

Lee K, Zhang M, Liu H, Yang D, Burke TR Jr.

J Med Chem. 2003 Jun 19;46(13):2621-30.

PMID:
12801226
7.

Cyclic phosphopeptides for interference with Grb2 SH2 domain signal transduction prepared by ring-closing metathesis and phosphorylation.

Dekker FJ, de Mol NJ, Fischer MJ, Kemmink J, Liskamp RM.

Org Biomol Chem. 2003 Oct 7;1(19):3297-303.

PMID:
14584793
8.
9.

Macrocyclization in the design of Grb2 SH2 domain-binding ligands exhibiting high potency in whole-cell systems.

Wei CQ, Gao Y, Lee K, Guo R, Li B, Zhang M, Yang D, Burke TR Jr.

J Med Chem. 2003 Jan 16;46(2):244-54.

PMID:
12519063
10.

Structure-based design of potent Grb2-SH2 domain antagonists not relying on phosphotyrosine mimics.

Jiang S, Li P, Peach ML, Bindu L, Worthy KW, Fisher RJ, Burke TR Jr, Nicklaus M, Roller PP.

Biochem Biophys Res Commun. 2006 Oct 20;349(2):497-503. Epub 2006 Aug 22.

PMID:
16945340
11.

Potent inhibition of Grb2 SH2 domain binding by non-phosphate-containing ligands.

Yao ZJ, King CR, Cao T, Kelley J, Milne GW, Voigt JH, Burke TR Jr.

J Med Chem. 1999 Jan 14;42(1):25-35.

PMID:
9888830
12.

Novel peptide inhibitors for Grb2 SH2 domain and their detection by surface plasmon resonance.

Lung FD, Tsai JY, Wei SY, Cheng JW, Chen C, Li P, Roller PP.

J Pept Res. 2002 Sep;60(3):143-9.

PMID:
12213123
13.

Evaluation of macrocyclic Grb2 SH2 domain-binding peptide mimetics prepared by ring-closing metathesis of C-terminal allylglycines with an N-terminal beta-vinyl-substituted phosphotyrosyl mimetic.

Oishi S, Karki RG, Shi ZD, Worthy KM, Bindu L, Chertov O, Esposito D, Frank P, Gillette WK, Maderia M, Hartley J, Nicklaus MC, Barchi JJ Jr, Fisher RJ, Burke TR Jr.

Bioorg Med Chem. 2005 Apr 1;13(7):2431-8.

PMID:
15755645
14.

Crystal structures of the SH2 domain of Grb2: highlight on the binding of a new high-affinity inhibitor.

Nioche P, Liu WQ, Broutin I, Charbonnier F, Latreille MT, Vidal M, Roques B, Garbay C, Ducruix A.

J Mol Biol. 2002 Feb 1;315(5):1167-77.

PMID:
11827484
15.

Application of azide-alkyne cycloaddition 'click chemistry' for the synthesis of Grb2 SH2 domain-binding macrocycles.

Choi WJ, Shi ZD, Worthy KM, Bindu L, Karki RG, Nicklaus MC, Fisher RJ, Burke TR Jr.

Bioorg Med Chem Lett. 2006 Oct 15;16(20):5265-9.

16.

Solution structure of the SH2 domain of Grb2/Ash complexed with EGF receptor-derived phosphotyrosine-containing peptide.

Tsuchiya S, Ogura K, Hatanaka H, Nagata K, Terasawa H, Mandiyan V, Schlessinger J, Aimoto S, Ohta H, Inagaki F.

J Biochem. 1999 Jun;125(6):1151-9.

17.

Solution structure of the SH2 domain of Grb2 complexed with the Shc-derived phosphotyrosine-containing peptide.

Ogura K, Tsuchiya S, Terasawa H, Yuzawa S, Hatanaka H, Mandiyan V, Schlessinger J, Inagaki F.

J Mol Biol. 1999 Jun 11;289(3):439-45.

PMID:
10356320
18.

Grb2 SH2 domain-binding peptide analogs as potential anticancer agents.

Lung FD, Tsai JY.

Biopolymers. 2003;71(2):132-40. Review.

PMID:
12767115
19.

Structural and energetic aspects of Grb2-SH2 domain-swapping.

Benfield AP, Whiddon BB, Clements JH, Martin SF.

Arch Biochem Biophys. 2007 Jun 1;462(1):47-53. Epub 2007 Apr 2.

20.

Structural basis for a non-phosphorus-containing cyclic peptide binding to Grb2-SH2 domain with high affinity.

Li P, Zhang M, Peach ML, Zhang X, Liu H, Nicklaus M, Yang D, Roller PP.

Biochem Biophys Res Commun. 2003 Aug 8;307(4):1038-44.

PMID:
12878216

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