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Rapid turnover of mcl-1 couples translation to cell survival and apoptosis.

Adams KW, Cooper GM.

J Biol Chem. 2007 Mar 2;282(9):6192-200. Epub 2007 Jan 2.


Cycloheximide Can Induce Bax/Bak Dependent Myeloid Cell Death Independently of Multiple BH3-Only Proteins.

Goodall KJ, Finch-Edmondson ML, van Vuuren J, Yeoh GC, Gentle IE, Vince JE, Ekert PG, Vaux DL, Callus BA.

PLoS One. 2016 Nov 2;11(11):e0164003. doi: 10.1371/journal.pone.0164003. eCollection 2016.


Semisynthetic homoharringtonine induces apoptosis via inhibition of protein synthesis and triggers rapid myeloid cell leukemia-1 down-regulation in myeloid leukemia cells.

Tang R, Faussat AM, Majdak P, Marzac C, Dubrulle S, Marjanovic Z, Legrand O, Marie JP.

Mol Cancer Ther. 2006 Mar;5(3):723-31.


Triggering of apoptosis by Puma is determined by the threshold set by prosurvival Bcl-2 family proteins.

Callus BA, Moujallad DM, Silke J, Gerl R, Jabbour AM, Ekert PG, Vaux DL.

J Mol Biol. 2008 Dec 12;384(2):313-23. doi: 10.1016/j.jmb.2008.09.041. Epub 2008 Sep 25.


Granulocyte macrophage colony-stimulating factor signaling and proteasome inhibition delay neutrophil apoptosis by increasing the stability of Mcl-1.

Derouet M, Thomas L, Cross A, Moots RJ, Edwards SW.

J Biol Chem. 2004 Jun 25;279(26):26915-21. Epub 2004 Apr 12.


Mcl-1 is downregulated in cisplatin-induced apoptosis, and proteasome inhibitors restore Mcl-1 and promote survival in renal tubular epithelial cells.

Yang C, Kaushal V, Shah SV, Kaushal GP.

Am J Physiol Renal Physiol. 2007 Jun;292(6):F1710-7. Epub 2007 Feb 20.


VSV virotherapy improves chemotherapy by triggering apoptosis due to proteasomal degradation of Mcl-1.

Schache P, Gürlevik E, Strüver N, Woller N, Malek N, Zender L, Manns M, Wirth T, Kühnel F, Kubicka S.

Gene Ther. 2009 Jul;16(7):849-61. doi: 10.1038/gt.2009.39. Epub 2009 Apr 16.


Role of Bcl-2 family members in anoxia induced cell death.

Shroff EH, Snyder C, Chandel NS.

Cell Cycle. 2007 Apr 1;6(7):807-9. Epub 2007 Apr 22. Review.


Reciprocal protection of Mcl-1 and Bim from ubiquitin-proteasome degradation.

Wuillème-Toumi S, Trichet V, Gomez-Bougie P, Gratas C, Bataille R, Amiot M.

Biochem Biophys Res Commun. 2007 Oct 5;361(4):865-9. Epub 2007 Jul 24.


NBK/BIK antagonizes MCL-1 and BCL-XL and activates BAK-mediated apoptosis in response to protein synthesis inhibition.

Shimazu T, Degenhardt K, Nur-E-Kamal A, Zhang J, Yoshida T, Zhang Y, Mathew R, White E, Inouye M.

Genes Dev. 2007 Apr 15;21(8):929-41. Epub 2007 Apr 2.


Accumulation of the pro-apoptotic factor Bak is controlled by antagonist factor Mcl-1 availability.

Minet E, Cosse JP, Demazy C, Raes M, Michiels C.

Apoptosis. 2006 Jun;11(6):1039-47.


Pseudomonas exotoxin A-mediated apoptosis is Bak dependent and preceded by the degradation of Mcl-1.

Du X, Youle RJ, FitzGerald DJ, Pastan I.

Mol Cell Biol. 2010 Jul;30(14):3444-52. doi: 10.1128/MCB.00813-09. Epub 2010 May 10.


Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins.

Willis SN, Chen L, Dewson G, Wei A, Naik E, Fletcher JI, Adams JM, Huang DC.

Genes Dev. 2005 Jun 1;19(11):1294-305. Epub 2005 May 18.


p14(ARF)-induced apoptosis in p53 protein-deficient cells is mediated by BH3-only protein-independent derepression of Bak protein through down-regulation of Mcl-1 and Bcl-xL proteins.

Müer A, Overkamp T, Gillissen B, Richter A, Pretzsch T, Milojkovic A, Dörken B, Daniel PT, Hemmati P.

J Biol Chem. 2012 May 18;287(21):17343-52. doi: 10.1074/jbc.M111.314898. Epub 2012 Feb 21.


MCL-1 inhibits BAX in the absence of MCL-1/BAX Interaction.

Germain M, Milburn J, Duronio V.

J Biol Chem. 2008 Mar 7;283(10):6384-92. Epub 2007 Dec 18.


Transcriptional and translational control of Mcl-1 during apoptosis.

Iglesias-Serret D, Piqué M, Gil J, Pons G, López JM.

Arch Biochem Biophys. 2003 Sep 15;417(2):141-52.


Cdk1/cyclin B plays a key role in mitotic arrest-induced apoptosis by phosphorylation of Mcl-1, promoting its degradation and freeing Bak from sequestration.

Chu R, Terrano DT, Chambers TC.

Biochem Pharmacol. 2012 Jan 15;83(2):199-206. doi: 10.1016/j.bcp.2011.10.008. Epub 2011 Oct 18.


Vinblastine induces acute, cell cycle phase-independent apoptosis in some leukemias and lymphomas and can induce acute apoptosis in others when Mcl-1 is suppressed.

Salerni BL, Bates DJ, Albershardt TC, Lowrey CH, Eastman A.

Mol Cancer Ther. 2010 Apr;9(4):791-802. doi: 10.1158/1535-7163.MCT-10-0028. Epub 2010 Apr 6.


Apoptosis induced by the kinase inhibitor BAY 43-9006 in human leukemia cells involves down-regulation of Mcl-1 through inhibition of translation.

Rahmani M, Davis EM, Bauer C, Dent P, Grant S.

J Biol Chem. 2005 Oct 21;280(42):35217-27. Epub 2005 Aug 18.

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