Format
Sort by
Items per page

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 141

1.

Liver-infiltrating lymphocytes in chronic human hepatitis C virus infection display an exhausted phenotype with high levels of PD-1 and low levels of CD127 expression.

Radziewicz H, Ibegbu CC, Fernandez ML, Workowski KA, Obideen K, Wehbi M, Hanson HL, Steinberg JP, Masopust D, Wherry EJ, Altman JD, Rouse BT, Freeman GJ, Ahmed R, Grakoui A.

J Virol. 2007 Mar;81(6):2545-53.

2.

Functional restoration of HCV-specific CD8 T cells by PD-1 blockade is defined by PD-1 expression and compartmentalization.

Nakamoto N, Kaplan DE, Coleclough J, Li Y, Valiga ME, Kaminski M, Shaked A, Olthoff K, Gostick E, Price DA, Freeman GJ, Wherry EJ, Chang KM.

Gastroenterology. 2008 Jun;134(7):1927-37, 1937.e1-2. doi: 10.1053/j.gastro.2008.02.033.

3.

Bim-mediated apoptosis and PD-1/PD-L1 pathway impair reactivity of PD1(+)/CD127(-) HCV-specific CD8(+) cells targeting the virus in chronic hepatitis C virus infection.

Larrubia JR, Benito-Martínez S, Miquel J, Calvino M, Sanz-de-Villalobos E, González-Praetorius A, Albertos S, García-Garzón S, Lokhande M, Parra-Cid T.

Cell Immunol. 2011;269(2):104-14. doi: 10.1016/j.cellimm.2011.03.011.

PMID:
21481848
4.

Dysfunction and functional restoration of HCV-specific CD8 responses in chronic hepatitis C virus infection.

Penna A, Pilli M, Zerbini A, Orlandini A, Mezzadri S, Sacchelli L, Missale G, Ferrari C.

Hepatology. 2007 Mar;45(3):588-601.

PMID:
17326153
5.

High-programmed death-1 levels on hepatitis C virus-specific T cells during acute infection are associated with viral persistence and require preservation of cognate antigen during chronic infection.

Rutebemberwa A, Ray SC, Astemborski J, Levine J, Liu L, Dowd KA, Clute S, Wang C, Korman A, Sette A, Sidney J, Pardoll DM, Cox AL.

J Immunol. 2008 Dec 15;181(12):8215-25.

6.

Analysis of CD127 and KLRG1 expression on hepatitis C virus-specific CD8+ T cells reveals the existence of different memory T-cell subsets in the peripheral blood and liver.

Bengsch B, Spangenberg HC, Kersting N, Neumann-Haefelin C, Panther E, von Weizsäcker F, Blum HE, Pircher H, Thimme R.

J Virol. 2007 Jan;81(2):945-53.

7.

Upregulation of PD-1 expression on circulating and intrahepatic hepatitis C virus-specific CD8+ T cells associated with reversible immune dysfunction.

Golden-Mason L, Palmer B, Klarquist J, Mengshol JA, Castelblanco N, Rosen HR.

J Virol. 2007 Sep;81(17):9249-58.

8.

Antiviral intrahepatic T-cell responses can be restored by blocking programmed death-1 pathway in chronic hepatitis B.

Fisicaro P, Valdatta C, Massari M, Loggi E, Biasini E, Sacchelli L, Cavallo MC, Silini EM, Andreone P, Missale G, Ferrari C.

Gastroenterology. 2010 Feb;138(2):682-93, 693.e1-4. doi: 10.1053/j.gastro.2009.09.052.

PMID:
19800335
9.

Liver environment and HCV replication affect human T-cell phenotype and expression of inhibitory receptors.

Kroy DC, Ciuffreda D, Cooperrider JH, Tomlinson M, Hauck GD, Aneja J, Berger C, Wolski D, Carrington M, Wherry EJ, Chung RT, Tanabe KK, Elias N, Freeman GJ, de Kruyff RH, Misdraji J, Kim AY, Lauer GM.

Gastroenterology. 2014 Feb;146(2):550-61. doi: 10.1053/j.gastro.2013.10.022.

10.

Synergistic reversal of intrahepatic HCV-specific CD8 T cell exhaustion by combined PD-1/CTLA-4 blockade.

Nakamoto N, Cho H, Shaked A, Olthoff K, Valiga ME, Kaminski M, Gostick E, Price DA, Freeman GJ, Wherry EJ, Chang KM.

PLoS Pathog. 2009 Feb;5(2):e1000313. doi: 10.1371/journal.ppat.1000313.

11.

Impaired hepatitis C virus (HCV)-specific effector CD8+ T cells undergo massive apoptosis in the peripheral blood during acute HCV infection and in the liver during the chronic phase of infection.

Radziewicz H, Ibegbu CC, Hon H, Osborn MK, Obideen K, Wehbi M, Freeman GJ, Lennox JL, Workowski KA, Hanson HL, Grakoui A.

J Virol. 2008 Oct;82(20):9808-22. doi: 10.1128/JVI.01075-08.

12.

Factors that determine the antiviral efficacy of HCV-specific CD8(+) T cells ex vivo.

Seigel B, Bengsch B, Lohmann V, Bartenschlager R, Blum HE, Thimme R.

Gastroenterology. 2013 Feb;144(2):426-36. doi: 10.1053/j.gastro.2012.10.047.

PMID:
23142136
13.

Costimulatory molecule programmed death-1 in the cytotoxic response during chronic hepatitis C.

Larrubia JR, Benito-Martínez S, Miquel J, Calvino M, Sanz-de-Villalobos E, Parra-Cid T.

World J Gastroenterol. 2009 Nov 7;15(41):5129-40. Review.

14.

PD-1 expression on peripheral CD8+ TEM/TEMRA subsets closely correlated with HCV viral load in chronic hepatitis C patients.

Shen T, Zheng J, Xu C, Liu J, Zhang W, Lu F, Zhuang H.

Virol J. 2010 Nov 12;7:310. doi: 10.1186/1743-422X-7-310.

15.

Persistent hepatitis C virus (HCV) infection impairs HCV-specific cytotoxic T cell reactivity through Mcl-1/Bim imbalance due to CD127 down-regulation.

Larrubia JR, Lokhande MU, García-Garzón S, Miquel J, González-Praetorius A, Parra-Cid T, Sanz-de-Villalobos E.

J Viral Hepat. 2013 Feb;20(2):85-94. doi: 10.1111/j.1365-2893.2012.01618.x.

PMID:
23301543
16.

A heterogeneous hierarchy of co-regulatory receptors regulates exhaustion of HCV-specific CD8 T cells in patients with chronic hepatitis C.

Owusu Sekyere S, Suneetha PV, Kraft AR, Zhang S, Dietz J, Sarrazin C, Manns MP, Schlaphoff V, Cornberg M, Wedemeyer H.

J Hepatol. 2015 Jan;62(1):31-40. doi: 10.1016/j.jhep.2014.08.008.

PMID:
25131771
17.

HCV-specific T cells in HCV/HIV co-infection show elevated frequencies of dual Tim-3/PD-1 expression that correlate with liver disease progression.

Vali B, Jones RB, Sakhdari A, Sheth PM, Clayton K, Yue FY, Gyenes G, Wong D, Klein MB, Saeed S, Benko E, Kovacs C, Kaul R, Ostrowski MA.

Eur J Immunol. 2010 Sep;40(9):2493-505. doi: 10.1002/eji.201040340.

18.

Lack of full CD8 functional restoration after antiviral treatment for acute and chronic hepatitis C virus infection.

Missale G, Pilli M, Zerbini A, Penna A, Ravanetti L, Barili V, Orlandini A, Molinari A, Fasano M, Santantonio T, Ferrari C.

Gut. 2012 Jul;61(7):1076-84. doi: 10.1136/gutjnl-2011-300515.

PMID:
22337949
19.

Coexpression of PD-1, 2B4, CD160 and KLRG1 on exhausted HCV-specific CD8+ T cells is linked to antigen recognition and T cell differentiation.

Bengsch B, Seigel B, Ruhl M, Timm J, Kuntz M, Blum HE, Pircher H, Thimme R.

PLoS Pathog. 2010 Jun 10;6(6):e1000947. doi: 10.1371/journal.ppat.1000947.

20.

Transient CD86 expression on hepatitis C virus-specific CD8+ T cells in acute infection is linked to sufficient IL-2 signaling.

Radziewicz H, Ibegbu CC, Hon H, Bédard N, Bruneau J, Workowski KA, Knechtle SJ, Kirk AD, Larsen CP, Shoukry NH, Grakoui A.

J Immunol. 2010 Mar 1;184(5):2410-22. doi: 10.4049/jimmunol.0902994.

Supplemental Content

Support Center