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Items: 1 to 20 of 104

1.

Pyridoxamine analogues scavenge lipid-derived gamma-ketoaldehydes and protect against H2O2-mediated cytotoxicity.

Davies SS, Brantley EJ, Voziyan PA, Amarnath V, Zagol-Ikapitte I, Boutaud O, Hudson BG, Oates JA, Roberts LJ 2nd.

Biochemistry. 2006 Dec 26;45(51):15756-67. Epub 2006 Dec 6.

2.

Low concentrations of reactive gamma-ketoaldehydes prime thromboxane-dependent human platelet aggregation via p38-MAPK activation.

Bernoud-Hubac N, Alam DA, Lefils J, Davies SS, Amarnath V, Guichardant M, Roberts LJ 2nd, Lagarde M.

Biochim Biophys Acta. 2009 Apr;1791(4):307-13. doi: 10.1016/j.bbalip.2009.02.003. Epub 2009 Feb 21.

PMID:
19233311
4.

Isoketals: highly reactive gamma-ketoaldehydes formed from the H2-isoprostane pathway.

Davies SS, Amarnath V, Roberts LJ 2nd.

Chem Phys Lipids. 2004 Mar;128(1-2):85-99. Review.

PMID:
15037155
5.

Pyridoxamine: an extremely potent scavenger of 1,4-dicarbonyls.

Amarnath V, Amarnath K, Amarnath K, Davies S, Roberts LJ 2nd.

Chem Res Toxicol. 2004 Mar;17(3):410-5.

PMID:
15025512
6.

Modulation of protein function by isoketals and levuglandins.

Davies SS.

Subcell Biochem. 2008;49:49-70. doi: 10.1007/978-1-4020-8831-5_2. Review.

PMID:
18751907
7.

Localization of isoketal adducts in vivo using a single-chain antibody.

Davies SS, Talati M, Wang X, Mernaugh RL, Amarnath V, Fessel J, Meyrick BO, Sheller J, Roberts LJ 2nd.

Free Radic Biol Med. 2004 May 1;36(9):1163-74.

PMID:
15082070
8.

Characterization of scavengers of gamma-ketoaldehydes that do not inhibit prostaglandin biosynthesis.

Zagol-Ikapitte I, Amarnath V, Bala M, Roberts LJ 2nd, Oates JA, Boutaud O.

Chem Res Toxicol. 2010 Jan;23(1):240-50. doi: 10.1021/tx900407a.

10.

Effects of reactive gamma-ketoaldehydes formed by the isoprostane pathway (isoketals) and cyclooxygenase pathway (levuglandins) on proteasome function.

Davies SS, Amarnath V, Montine KS, Bernoud-Hubac N, Boutaud O, Montine TJ, Roberts LJ 2nd.

FASEB J. 2002 May;16(7):715-7. Epub 2002 Mar 12.

PMID:
11978738
11.
12.

Products of the isoprostane pathway: unique bioactive compounds and markers of lipid peroxidation.

Roberts LJ 2nd, Morrow JD.

Cell Mol Life Sci. 2002 May;59(5):808-20. Review.

PMID:
12088281
13.

Formation of highly reactive gamma-ketoaldehydes (neuroketals) as products of the neuroprostane pathway.

Bernoud-Hubac N, Davies SS, Boutaud O, Montine TJ, Roberts LJ 2nd.

J Biol Chem. 2001 Aug 17;276(33):30964-70. Epub 2001 Jun 18.

14.

Determination of the Pharmacokinetics and Oral Bioavailability of Salicylamine, a Potent γ-Ketoaldehyde Scavenger, by LC/MS/MS.

Zagol-Ikapitte I, Matafonova E, Amarnath V, Bodine CL, Boutaud O, Tirona RG, Oates JA, Roberts Ii LJ, Davies SS.

Pharmaceutics. 2010 Feb 1;2(1):18-29.

15.

Selective gamma-ketoaldehyde scavengers protect Nav1.5 from oxidant-induced inactivation.

Nakajima T, Davies SS, Matafonova E, Potet F, Amarnath V, Tallman KA, Serwa RA, Porter NA, Balser JR, Kupershmidt S, Roberts LJ 3rd.

J Mol Cell Cardiol. 2010 Feb;48(2):352-9. doi: 10.1016/j.yjmcc.2009.11.016. Epub 2009 Dec 3.

16.

Characterization of the lysyl adducts formed from prostaglandin H2 via the levuglandin pathway.

Boutaud O, Brame CJ, Salomon RG, Roberts LJ 2nd, Oates JA.

Biochemistry. 1999 Jul 20;38(29):9389-96.

PMID:
10413514
17.

Scavenging of highly reactive gamma-ketoaldehydes attenuates cognitive dysfunction associated with epileptogenesis.

Pearson JN, Warren E, Liang LP, Roberts LJ 2nd, Patel M.

Neurobiol Dis. 2017 Feb;98:88-99. doi: 10.1016/j.nbd.2016.11.011. Epub 2016 Dec 5.

PMID:
27932305
18.

Modification of proteins by isoketal-containing oxidized phospholipids.

Brame CJ, Boutaud O, Davies SS, Yang T, Oates JA, Roden D, Roberts LJ 2nd.

J Biol Chem. 2004 Apr 2;279(14):13447-51. Epub 2004 Jan 10.

19.

Formation of gamma-ketoaldehyde-protein adducts during ethanol-induced liver injury in mice.

Roychowdhury S, McMullen MR, Pritchard MT, Li W, Salomon RG, Nagy LE.

Free Radic Biol Med. 2009 Dec 1;47(11):1526-38. doi: 10.1016/j.freeradbiomed.2009.07.015. Epub 2009 Jul 17.

20.

Reactive γ-ketoaldehydes promote protein misfolding and preamyloid oligomer formation in rapidly-activated atrial cells.

Sidorova TN, Yermalitskaya LV, Mace LC, Wells KS, Boutaud O, Prinsen JK, Davies SS, Roberts LJ 2nd, Dikalov SI, Glabe CG, Amarnath V, Barnett JV, Murray KT.

J Mol Cell Cardiol. 2015 Feb;79:295-302. doi: 10.1016/j.yjmcc.2014.11.013. Epub 2014 Nov 18.

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