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Items: 1 to 20 of 105


The beta-tail domain (betaTD) regulates physiologic ligand binding to integrin CD11b/CD18.

Gupta V, Gylling A, Alonso JL, Sugimori T, Ianakiev P, Xiong JP, Arnaout MA.

Blood. 2007 Apr 15;109(8):3513-20. Epub 2006 Dec 14.


Stable coordination of the inhibitory Ca2+ ion at the metal ion-dependent adhesion site in integrin CD11b/CD18 by an antibody-derived ligand aspartate: implications for integrin regulation and structure-based drug design.

Mahalingam B, Ajroud K, Alonso JL, Anand S, Adair BD, Horenstein AL, Malavasi F, Xiong JP, Arnaout MA.

J Immunol. 2011 Dec 15;187(12):6393-401. doi: 10.4049/jimmunol.1102394. Epub 2011 Nov 16.


EM structure of the ectodomain of integrin CD11b/CD18 and localization of its ligand-binding site relative to the plasma membrane.

Adair BD, Xiong JP, Alonso JL, Hyman BT, Arnaout MA.

PLoS One. 2013;8(2):e57951. doi: 10.1371/journal.pone.0057951. Epub 2013 Feb 28.


Identification of the complement iC3b binding site in the beta 2 integrin CR3 (CD11b/CD18).

Ueda T, Rieu P, Brayer J, Arnaout MA.

Proc Natl Acad Sci U S A. 1994 Oct 25;91(22):10680-4.


Modulation of CD11b/CD18 adhesive activity by its extracellular, membrane-proximal regions.

Xiong YM, Chen J, Zhang L.

J Immunol. 2003 Jul 15;171(2):1042-50.


Expression of a structural domain of the beta 2 subunit essential for alpha M beta 2 ligand recognition.

Goodman TG, DeGraaf ME, Fischer HD, Bajt ML.

J Leukoc Biol. 1998 Dec;64(6):767-73.


Distinct roles for the alpha and beta subunits in the functions of integrin alphaMbeta2.

Solovjov DA, Pluskota E, Plow EF.

J Biol Chem. 2005 Jan 14;280(2):1336-45. Epub 2004 Oct 14.


Identification of novel agonists of the integrin CD11b/CD18.

Faridi MH, Maiguel D, Barth CJ, Stoub D, Day R, Schürer S, Gupta V.

Bioorg Med Chem Lett. 2009 Dec 15;19(24):6902-6. doi: 10.1016/j.bmcl.2009.10.077. Epub 2009 Oct 22.


Structure-function of the putative I-domain within the integrin beta 2 subunit.

Xiong YM, Zhang L.

J Biol Chem. 2001 Jun 1;276(22):19340-9. Epub 2001 Mar 12.


An Alternative Phosphorylation Switch in Integrin β2 (CD18) Tail for Dok1 Binding.

Gupta S, Chit JC, Feng C, Bhunia A, Tan SM, Bhattacharjya S.

Sci Rep. 2015 Jun 25;5:11630. doi: 10.1038/srep11630.


Binding between the integrin alphaXbeta2 (CD11c/CD18) and heparin.

Vorup-Jensen T, Chi L, Gjelstrup LC, Jensen UB, Jewett CA, Xie C, Shimaoka M, Linhardt RJ, Springer TA.

J Biol Chem. 2007 Oct 19;282(42):30869-77. Epub 2007 Aug 14.


Random phage-epitope library based identification of a peptide antagonist of Mac-1 β2 integrin ligand binding.

Houimel M, Mazzucchelli L.

Matrix Biol. 2012 Jan;31(1):66-77. doi: 10.1016/j.matbio.2011.10.003. Epub 2011 Nov 11.


Binding Affinity of Metal Ions to the CD11b A-domain Is Regulated by Integrin Activation and Ligands.

Ajroud K, Sugimori T, Goldmann WH, Fathallah DM, Xiong JP, Arnaout MA.

J Biol Chem. 2004 Jun 11;279(24):25483-8. Epub 2004 Apr 7.


Characterization of a novel monoclonal antibody with restricted specificity to the free beta 2 integrin alpha M CD11b subunit.

Tanfous NG, Essafi M, Larguech B, Barbouche R, Fathallah DM.

Hybridoma (Larchmt). 2007 Dec;26(6):373-9.


Association of BAP31 with CD11b/CD18. Potential role in intracellular trafficking of CD11b/CD18 in neutrophils.

Zen K, Utech M, Liu Y, Soto I, Nusrat A, Parkos CA.

J Biol Chem. 2004 Oct 22;279(43):44924-30. Epub 2004 Aug 4.


Characterization of ICAM-4 binding to the I domains of the CD11a/CD18 and CD11b/CD18 leukocyte integrins.

Ihanus E, Uotila L, Toivanen A, Stefanidakis M, Bailly P, Cartron JP, Gahmberg CG.

Eur J Biochem. 2003 Apr;270(8):1710-23.


Small molecule agonists of integrin CD11b/CD18 do not induce global conformational changes and are significantly better than activating antibodies in reducing vascular injury.

Faridi MH, Altintas MM, Gomez C, Duque JC, Vazquez-Padron RI, Gupta V.

Biochim Biophys Acta. 2013 Jun;1830(6):3696-710. doi: 10.1016/j.bbagen.2013.02.018. Epub 2013 Feb 26.

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