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Items: 1 to 20 of 215

1.

Parallel solid synthesis of inhibitors of the essential cell division FtsZ enzyme as a new potential class of antibacterials.

Paradis-Bleau C, Beaumont M, Sanschagrin F, Voyer N, Levesque RC.

Bioorg Med Chem. 2007 Feb 1;15(3):1330-40. Epub 2006 Nov 10.

PMID:
17157508
2.

GTP analogue inhibits polymerization and GTPase activity of the bacterial protein FtsZ without affecting its eukaryotic homologue tubulin.

Läppchen T, Hartog AF, Pinas VA, Koomen GJ, den Blaauwen T.

Biochemistry. 2005 May 31;44(21):7879-84.

PMID:
15910002
3.

Discovery of a small molecule that inhibits cell division by blocking FtsZ, a novel therapeutic target of antibiotics.

Wang J, Galgoci A, Kodali S, Herath KB, Jayasuriya H, Dorso K, Vicente F, González A, Cully D, Bramhill D, Singh S.

J Biol Chem. 2003 Nov 7;278(45):44424-8. Epub 2003 Sep 2.

4.

Identification of Pseudomonas aeruginosa FtsZ peptide inhibitors as a tool for development of novel antimicrobials.

Paradis-Bleau C, Sanschagrin F, Levesque RC.

J Antimicrob Chemother. 2004 Jul;54(1):278-80. Epub 2004 Jun 9. No abstract available.

PMID:
15190020
5.

Antibacterial alkoxybenzamide inhibitors of the essential bacterial cell division protein FtsZ.

Czaplewski LG, Collins I, Boyd EA, Brown D, East SP, Gardiner M, Fletcher R, Haydon DJ, Henstock V, Ingram P, Jones C, Noula C, Kennison L, Rockley C, Rose V, Thomaides-Brears HB, Ure R, Whittaker M, Stokes NR.

Bioorg Med Chem Lett. 2009 Jan 15;19(2):524-7. doi: 10.1016/j.bmcl.2008.11.021. Epub 2008 Nov 13.

PMID:
19064318
6.

Independence between GTPase active sites in the Escherichia coli cell division protein FtsZ.

Salvarelli E, Krupka M, Rivas G, Vicente M, Mingorance J.

FEBS Lett. 2011 Dec 15;585(24):3880-3. doi: 10.1016/j.febslet.2011.10.046. Epub 2011 Nov 3.

7.

An inhibitor of FtsZ with potent and selective anti-staphylococcal activity.

Haydon DJ, Stokes NR, Ure R, Galbraith G, Bennett JM, Brown DR, Baker PJ, Barynin VV, Rice DW, Sedelnikova SE, Heal JR, Sheridan JM, Aiwale ST, Chauhan PK, Srivastava A, Taneja A, Collins I, Errington J, Czaplewski LG.

Science. 2008 Sep 19;321(5896):1673-5. doi: 10.1126/science.1159961.

8.

Triaminotriazine DNA helicase inhibitors with antibacterial activity.

McKay GA, Reddy R, Arhin F, Belley A, Lehoux D, Moeck G, Sarmiento I, Parr TR, Gros P, Pelletier J, Far AR.

Bioorg Med Chem Lett. 2006 Mar 1;16(5):1286-90. Epub 2005 Dec 15.

PMID:
16343901
9.

FtsZ inhibition: a promising approach for antistaphylococcal therapy.

Singh P, Panda D.

Drug News Perspect. 2010 Jun;23(5):295-304. doi: 10.1358/dnp.2010.23.5.1429489. Review.

PMID:
20603653
10.

A rhodanine derivative CCR-11 inhibits bacterial proliferation by inhibiting the assembly and GTPase activity of FtsZ.

Singh P, Jindal B, Surolia A, Panda D.

Biochemistry. 2012 Jul 10;51(27):5434-42. Epub 2012 Jun 28.

PMID:
22703373
11.

Effective GTP-replacing FtsZ inhibitors and antibacterial mechanism of action.

Artola M, Ruiz-Avila LB, Vergoñós A, Huecas S, Araujo-Bazán L, Martín-Fontecha M, Vázquez-Villa H, Turrado C, Ramírez-Aportela E, Hoegl A, Nodwell M, Barasoain I, Chacón P, Sieber SA, Andreu JM, López-Rodríguez ML.

ACS Chem Biol. 2015 Mar 20;10(3):834-43. doi: 10.1021/cb500974d. Epub 2014 Dec 30.

PMID:
25486266
12.

Synthesis and biological evaluation of N-acylhydrazones as inhibitors of MurC and MurD ligases.

Sink R, Kovac A, Tomasić T, Rupnik V, Boniface A, Bostock J, Chopra I, Blanot D, Masic LP, Gobec S, Zega A.

ChemMedChem. 2008 Sep;3(9):1362-70. doi: 10.1002/cmdc.200800087.

PMID:
18651694
13.

Insights into nucleotide recognition by cell division protein FtsZ from a mant-GTP competition assay and molecular dynamics.

Schaffner-Barbero C, Gil-Redondo R, Ruiz-Avila LB, Huecas S, Läppchen T, den Blaauwen T, Diaz JF, Morreale A, Andreu JM.

Biochemistry. 2010 Dec 14;49(49):10458-72. doi: 10.1021/bi101577p. Epub 2010 Nov 17.

PMID:
21058659
14.

Design, synthesis and structure-activity relationships of substituted oxazole-benzamide antibacterial inhibitors of FtsZ.

Stokes NR, Baker N, Bennett JM, Chauhan PK, Collins I, Davies DT, Gavade M, Kumar D, Lancett P, Macdonald R, Macleod L, Mahajan A, Mitchell JP, Nayal N, Nayal YN, Pitt GR, Singh M, Yadav A, Srivastava A, Czaplewski LG, Haydon DJ.

Bioorg Med Chem Lett. 2014 Jan 1;24(1):353-9. doi: 10.1016/j.bmcl.2013.11.002. Epub 2013 Nov 13.

PMID:
24287381
15.

Identification of a new class of FtsZ inhibitors by structure-based design and in vitro screening.

Chan FY, Sun N, Neves MA, Lam PC, Chung WH, Wong LK, Chow HY, Ma DL, Chan PH, Leung YC, Chan TH, Abagyan R, Wong KY.

J Chem Inf Model. 2013 Aug 26;53(8):2131-40. doi: 10.1021/ci400203f. Epub 2013 Jul 25.

PMID:
23848971
16.

Creating an antibacterial with in vivo efficacy: synthesis and characterization of potent inhibitors of the bacterial cell division protein FtsZ with improved pharmaceutical properties.

Haydon DJ, Bennett JM, Brown D, Collins I, Galbraith G, Lancett P, Macdonald R, Stokes NR, Chauhan PK, Sutariya JK, Nayal N, Srivastava A, Beanland J, Hall R, Henstock V, Noula C, Rockley C, Czaplewski L.

J Med Chem. 2010 May 27;53(10):3927-36. doi: 10.1021/jm9016366.

17.

Inhibition of bacterial cell division protein FtsZ by cinnamaldehyde.

Domadia P, Swarup S, Bhunia A, Sivaraman J, Dasgupta D.

Biochem Pharmacol. 2007 Sep 15;74(6):831-40. Epub 2007 Jun 23.

PMID:
17662960
18.

The development of FtsZ inhibitors as potential antibacterial agents.

Ma S, Ma S.

ChemMedChem. 2012 Jul;7(7):1161-72. doi: 10.1002/cmdc.201200156. Epub 2012 May 25. Review.

PMID:
22639193
19.

Synthesis of antimicrobial natural products targeting FtsZ: (+/-)-dichamanetin and (+/-)-2' ''-hydroxy-5' '-benzylisouvarinol-B.

Urgaonkar S, La Pierre HS, Meir I, Lund H, RayChaudhuri D, Shaw JT.

Org Lett. 2005 Dec 8;7(25):5609-12.

20.

Phenylpropanoids inhibit protofilament formation of Escherichia coli cell division protein FtsZ.

Hemaiswarya S, Soudaminikkutty R, Narasumani ML, Doble M.

J Med Microbiol. 2011 Sep;60(Pt 9):1317-25. doi: 10.1099/jmm.0.030536-0. Epub 2011 Apr 7.

PMID:
21474608

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