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Items: 1 to 20 of 84

1.

Design and synthesis of compounds that extend yeast replicative lifespan.

Yang H, Baur JA, Chen A, Miller C, Adams JK, Kisielewski A, Howitz KT, Zipkin RE, Sinclair DA.

Aging Cell. 2007 Feb;6(1):35-43. Epub 2006 Dec 5. Erratum in: Aging Cell. 2007 Aug;6(4):593. Adams, Jeffrey K [added]; Kisielewski, Anne [added]; Howitz, Konrad T [added]; Zipkin, Robert E [added].

2.

Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan.

Howitz KT, Bitterman KJ, Cohen HY, Lamming DW, Lavu S, Wood JG, Zipkin RE, Chung P, Kisielewski A, Zhang LL, Scherer B, Sinclair DA.

Nature. 2003 Sep 11;425(6954):191-6. Epub 2003 Aug 24.

PMID:
12939617
3.

Sirtuin activators mimic caloric restriction and delay ageing in metazoans.

Wood JG, Rogina B, Lavu S, Howitz K, Helfand SL, Tatar M, Sinclair D.

Nature. 2004 Aug 5;430(7000):686-9. Epub 2004 Jul 14. Erratum in: Nature. 2004 Sep 2;431(7004):107.

PMID:
15254550
4.

Sirtuin activators.

AlcaĆ­n FJ, Villalba JM.

Expert Opin Ther Pat. 2009 Apr;19(4):403-14. doi: 10.1517/13543770902762893. Review.

PMID:
19441923
5.

Does resveratrol activate yeast Sir2 in vivo?

Kaeberlein M, Kennedy BK.

Aging Cell. 2007 Aug;6(4):415-6. No abstract available.

6.

Sirtuin-independent effects of nicotinamide on lifespan extension from calorie restriction in yeast.

Tsuchiya M, Dang N, Kerr EO, Hu D, Steffen KK, Oakes JA, Kennedy BK, Kaeberlein M.

Aging Cell. 2006 Dec;5(6):505-14.

7.

Small-molecule allosteric activators of sirtuins.

Sinclair DA, Guarente L.

Annu Rev Pharmacol Toxicol. 2014;54:363-80. doi: 10.1146/annurev-pharmtox-010611-134657. Epub 2013 Oct 16. Review.

8.

Effects of 2-deoxyglucose and dehydroepiandrosterone on intracellular NAD(+) level, SIRT1 activity and replicative lifespan of human Hs68 cells.

Yang NC, Song TY, Chen MY, Hu ML.

Biogerontology. 2011 Dec;12(6):527-36. doi: 10.1007/s10522-011-9342-7. Epub 2011 May 21.

PMID:
21604001
9.

Structural basis for allosteric, substrate-dependent stimulation of SIRT1 activity by resveratrol.

Cao D, Wang M, Qiu X, Liu D, Jiang H, Yang N, Xu RM.

Genes Dev. 2015 Jun 15;29(12):1316-25. doi: 10.1101/gad.265462.115.

10.

A possibility of nutriceuticals as an anti-aging intervention: activation of sirtuins by promoting mammalian NAD biosynthesis.

Imai S.

Pharmacol Res. 2010 Jul;62(1):42-7. doi: 10.1016/j.phrs.2010.01.006. Epub 2010 Jan 18. Review.

11.

A novel assay for replicative lifespan in Saccharomyces cerevisiae.

Jarolim S, Millen J, Heeren G, Laun P, Goldfarb DS, Breitenbach M.

FEMS Yeast Res. 2004 Nov;5(2):169-77.

12.

Up-regulation of nicotinamide phosphoribosyltransferase and increase of NAD+ levels by glucose restriction extend replicative lifespan of human fibroblast Hs68 cells.

Yang NC, Song TY, Chang YZ, Chen MY, Hu ML.

Biogerontology. 2015 Feb;16(1):31-42. doi: 10.1007/s10522-014-9528-x. Epub 2014 Aug 22.

PMID:
25146190
13.

Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds.

Bonkowski MS, Sinclair DA.

Nat Rev Mol Cell Biol. 2016 Nov;17(11):679-690. doi: 10.1038/nrm.2016.93. Epub 2016 Aug 24. Review.

14.

Dietary activators of Sirt1.

Allard JS, Perez E, Zou S, de Cabo R.

Mol Cell Endocrinol. 2009 Feb 5;299(1):58-63. doi: 10.1016/j.mce.2008.10.018. Epub 2008 Nov 1. Review.

15.

The role of mammalian sirtuins in the regulation of metabolism, aging, and longevity.

Satoh A, Stein L, Imai S.

Handb Exp Pharmacol. 2011;206:125-62. doi: 10.1007/978-3-642-21631-2_7. Review.

16.

Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1.

Bitterman KJ, Anderson RM, Cohen HY, Latorre-Esteves M, Sinclair DA.

J Biol Chem. 2002 Nov 22;277(47):45099-107. Epub 2002 Sep 23.

17.

Mechanism of human SIRT1 activation by resveratrol.

Borra MT, Smith BC, Denu JM.

J Biol Chem. 2005 Apr 29;280(17):17187-95. Epub 2005 Mar 4.

18.

Resveratrol and novel potent activators of SIRT1: effects on aging and age-related diseases.

Knutson MD, Leeuwenburgh C.

Nutr Rev. 2008 Oct;66(10):591-6. doi: 10.1111/j.1753-4887.2008.00109.x. Review.

PMID:
18826454
19.

Linking sirtuins, IGF-I signaling, and starvation.

Longo VD.

Exp Gerontol. 2009 Jan-Feb;44(1-2):70-4. doi: 10.1016/j.exger.2008.06.005. Epub 2008 Jun 24. Review.

PMID:
18638538
20.

Resveratrol, sirtuins, and the promise of a DR mimetic.

Baur JA.

Mech Ageing Dev. 2010 Apr;131(4):261-9. doi: 10.1016/j.mad.2010.02.007. Epub 2010 Feb 26. Review.

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