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Effects of chronic growth hormone and insulin-like growth factor 1 deficiency on osteoarthritis severity in rat knee joints.

Ekenstedt KJ, Sonntag WE, Loeser RF, Lindgren BR, Carlson CS.

Arthritis Rheum. 2006 Dec;54(12):3850-8.


Adult-onset growth hormone and insulin-like growth factor I deficiency reduces neoplastic disease, modifies age-related pathology, and increases life span.

Sonntag WE, Carter CS, Ikeno Y, Ekenstedt K, Carlson CS, Loeser RF, Chakrabarty S, Lee S, Bennett C, Ingram R, Moore T, Ramsey M.

Endocrinology. 2005 Jul;146(7):2920-32. Epub 2005 Mar 24.


Growth hormone and IGF-I modulate local cerebral glucose utilization and ATP levels in a model of adult-onset growth hormone deficiency.

Sonntag WE, Bennett C, Ingram R, Donahue A, Ingraham J, Chen H, Moore T, Brunso-Bechtold JK, Riddle D.

Am J Physiol Endocrinol Metab. 2006 Sep;291(3):E604-10. Epub 2006 Apr 25.


Early-onset growth hormone deficiency results in diastolic dysfunction in adult-life and is prevented by growth hormone supplementation.

Groban L, Lin M, Kassik KA, Ingram RL, Sonntag WE.

Growth Horm IGF Res. 2011 Apr;21(2):81-8. doi: 10.1016/j.ghir.2011.01.003. Epub 2011 Mar 2.


Serum levels of insulin-like growth factor binding proteins (IGFBP)-4 and -5 correlate with bone mineral density in growth hormone (GH)-deficient adults and increase with GH replacement therapy.

Thorén M, Hilding A, Brismar T, Magnusson P, Degerblad M, Larsson L, Sääf M, Baylink DJ, Mohan S.

J Bone Miner Res. 1998 May;13(5):891-9.


Growth hormone (GH) regulation of circulating insulin-like growth factor-I levels during sexual maturation of the GH-deficient dwarf (dw/dw) male rat.

Crawford BA, Dobbie P, Bass JJ, Lewitt MS, Baxter RC, Handelsman DJ.

J Endocrinol. 1994 Jun;141(3):393-401.


Effects of a bisphosphonate on bone histomorphometry and dynamics in the canine cruciate deficiency model of osteoarthritis.

Myers SL, Brandt KD, Burr DB, O'Connor BL, Albrecht M.

J Rheumatol. 1999 Dec;26(12):2645-53.


Effects of long-term estrogen replacement therapy on osteoarthritis severity in cynomolgus monkeys.

Ham KD, Loeser RF, Lindgren BR, Carlson CS.

Arthritis Rheum. 2002 Jul;46(7):1956-64.


Elderly people with hypothalamic-pituitary disease and growth hormone deficiency: lipid profiles, body composition and quality of life compared with control subjects.

Li Voon Chong JS, Benbow S, Foy P, Wallymahmed ME, Wile D, MacFarlane IA.

Clin Endocrinol (Oxf). 2000 Nov;53(5):551-9.


Role of insulin-like growth factor-1 and growth hormone in growth inhibition induced by magnesium and zinc deficiencies.

Dørup I, Flyvbjerg A, Everts ME, Clausen T.

Br J Nutr. 1991 Nov;66(3):505-21.


Early-onset GH deficiency results in spatial memory impairment in mid-life and is prevented by GH supplementation.

Nieves-Martinez E, Sonntag WE, Wilson A, Donahue A, Molina DP, Brunso-Bechtold J, Nicolle MM.

J Endocrinol. 2010 Jan;204(1):31-6. doi: 10.1677/JOE-09-0323. Epub 2009 Oct 8.


Dendritic stability in a model of adult-onset IGF-I deficiency.

Grill JD, Sonntag WE, Riddle DR.

Growth Horm IGF Res. 2005 Oct;15(5):337-48.


Monitoring serum insulin-like growth factor-I (IGF-I), IGF binding protein-3 (IGFBP-3), IGF-I/IGFBP-3 molar ratio and leptin during growth hormone treatment for disordered growth.

Tillmann V, Patel L, Gill MS, Whatmore AJ, Price DA, Kibirige MS, Wales JK, Clayton PE.

Clin Endocrinol (Oxf). 2000 Sep;53(3):329-36.


Growth hormone and IGF-1 deficiency exacerbate high-fat diet-induced endothelial impairment in obese Lewis dwarf rats: implications for vascular aging.

Bailey-Downs LC, Sosnowska D, Toth P, Mitschelen M, Gautam T, Henthorn JC, Ballabh P, Koller A, Farley JA, Sonntag WE, Csiszar A, Ungvari Z.

J Gerontol A Biol Sci Med Sci. 2012 Jun;67(6):553-64. doi: 10.1093/gerona/glr197. Epub 2011 Nov 10.


Endothelin-1-induced focal cerebral ischemia in the growth hormone/IGF-1 deficient Lewis Dwarf rat.

Yan H, Mitschelen M, Toth P, Ashpole NM, Farley JA, Hodges EL, Warrington JP, Han S, Fung KM, Csiszar A, Ungvari Z, Sonntag WE.

J Gerontol A Biol Sci Med Sci. 2014 Nov;69(11):1353-62. doi: 10.1093/gerona/glu118. Epub 2014 Aug 6.

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