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Items: 1 to 20 of 55

1.

Computational studies for the structure and function of mRPE65.

Guo H, Zheng C, Gaillard ER.

J Theor Biol. 2007 Mar 21;245(2):312-8. Epub 2006 Oct 7.

PMID:
17123547
2.

Structure prediction of the RPE65 protein.

Guo H, Zheng C, Gaillard ER.

J Theor Biol. 2006 Sep 7;242(1):117-22. Epub 2006 Mar 23.

PMID:
16556451
3.

Specificity of binding of all-trans-retinyl ester to RPE65.

Maiti P, Gollapalli D, Rando RR.

Biochemistry. 2005 Nov 8;44(44):14463-9.

PMID:
16262246
4.

RPE65 is the isomerohydrolase in the retinoid visual cycle.

Moiseyev G, Chen Y, Takahashi Y, Wu BX, Ma JX.

Proc Natl Acad Sci U S A. 2005 Aug 30;102(35):12413-8. Epub 2005 Aug 22.

5.

Rpe65 is a retinyl ester binding protein that presents insoluble substrate to the isomerase in retinal pigment epithelial cells.

Mata NL, Moghrabi WN, Lee JS, Bui TV, Radu RA, Horwitz J, Travis GH.

J Biol Chem. 2004 Jan 2;279(1):635-43. Epub 2003 Oct 7.

7.

The roles of three palmitoylation sites of RPE65 in its membrane association and isomerohydrolase activity.

Takahashi Y, Moiseyev G, Chen Y, Ma JX.

Invest Ophthalmol Vis Sci. 2006 Dec;47(12):5191-6.

PMID:
17122102
8.

Retinyl esters are the substrate for isomerohydrolase.

Moiseyev G, Crouch RK, Goletz P, Oatis J Jr, Redmond TM, Ma JX.

Biochemistry. 2003 Feb 25;42(7):2229-38.

PMID:
12590612
9.

Acute radiolabeling of retinoids in eye tissues of normal and rpe65-deficient mice.

Qtaishat NM, Redmond TM, Pepperberg DR.

Invest Ophthalmol Vis Sci. 2003 Apr;44(4):1435-46.

PMID:
12657577
10.

A palmitoylation switch mechanism in the regulation of the visual cycle.

Xue L, Gollapalli DR, Maiti P, Jahng WJ, Rando RR.

Cell. 2004 Jun 11;117(6):761-71.

11.
12.

Retinal degeneration 12 (rd12): a new, spontaneously arising mouse model for human Leber congenital amaurosis (LCA).

Pang JJ, Chang B, Hawes NL, Hurd RE, Davisson MT, Li J, Noorwez SM, Malhotra R, McDowell JH, Kaushal S, Hauswirth WW, Nusinowitz S, Thompson DA, Heckenlively JR.

Mol Vis. 2005 Feb 28;11:152-62.

13.

Function of the protein RPE65 in the visual cycle.

Wolf G.

Nutr Rev. 2005 Mar;63(3):97-100. Review.

PMID:
15825812
14.
15.

Binding of RPE65 fragments to lipid monolayers and identification of its partners by glutathione S-transferase pull-down assays.

Trudel E, Beaufils S, Renault A, Breton R, Salesse C.

Biochemistry. 2006 Mar 14;45(10):3337-47.

PMID:
16519528
16.

RPE65 operates in the vertebrate visual cycle by stereospecifically binding all-trans-retinyl esters.

Gollapalli DR, Maiti P, Rando RR.

Biochemistry. 2003 Oct 14;42(40):11824-30. Erratum in: Biochemistry. 2004 Jun 8;43(22):7226.

PMID:
14529294
17.

Genetics and phenotypes of RPE65 mutations in inherited retinal degeneration.

Thompson DA, Gyürüs P, Fleischer LL, Bingham EL, McHenry CL, Apfelstedt-Sylla E, Zrenner E, Lorenz B, Richards JE, Jacobson SG, Sieving PA, Gal A.

Invest Ophthalmol Vis Sci. 2000 Dec;41(13):4293-9.

PMID:
11095629
18.

R91W mutation in Rpe65 leads to milder early-onset retinal dystrophy due to the generation of low levels of 11-cis-retinal.

Samardzija M, von Lintig J, Tanimoto N, Oberhauser V, Thiersch M, Remé CE, Seeliger M, Grimm C, Wenzel A.

Hum Mol Genet. 2008 Jan 15;17(2):281-92. Epub 2007 Oct 12.

PMID:
17933883
19.

Restoration of vision in RPE65-deficient Briard dogs using an AAV serotype 4 vector that specifically targets the retinal pigmented epithelium.

Le Meur G, Stieger K, Smith AJ, Weber M, Deschamps JY, Nivard D, Mendes-Madeira A, Provost N, Péréon Y, Cherel Y, Ali RR, Hamel C, Moullier P, Rolling F.

Gene Ther. 2007 Feb;14(4):292-303. Epub 2006 Oct 5.

PMID:
17024105
20.

Gene therapy restores vision-dependent behavior as well as retinal structure and function in a mouse model of RPE65 Leber congenital amaurosis.

Pang JJ, Chang B, Kumar A, Nusinowitz S, Noorwez SM, Li J, Rani A, Foster TC, Chiodo VA, Doyle T, Li H, Malhotra R, Teusner JT, McDowell JH, Min SH, Li Q, Kaushal S, Hauswirth WW.

Mol Ther. 2006 Mar;13(3):565-72. Epub 2005 Oct 11.

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