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Items: 1 to 20 of 105

1.

Numb is a suppressor of Hedgehog signalling and targets Gli1 for Itch-dependent ubiquitination.

Di Marcotullio L, Ferretti E, Greco A, De Smaele E, Po A, Sico MA, Alimandi M, Giannini G, Maroder M, Screpanti I, Gulino A.

Nat Cell Biol. 2006 Dec;8(12):1415-23. Epub 2006 Nov 19.

PMID:
17115028
2.

Multiple ubiquitin-dependent processing pathways regulate hedgehog/gli signaling: implications for cell development and tumorigenesis.

Di Marcotullio L, Ferretti E, Greco A, De Smaele E, Screpanti I, Gulino A.

Cell Cycle. 2007 Feb 15;6(4):390-3. Epub 2007 Feb 3.

PMID:
17312394
3.

Numb activates the E3 ligase Itch to control Gli1 function through a novel degradation signal.

Di Marcotullio L, Greco A, Mazzà D, Canettieri G, Pietrosanti L, Infante P, Coni S, Moretti M, De Smaele E, Ferretti E, Screpanti I, Gulino A.

Oncogene. 2011 Jan 6;30(1):65-76. doi: 10.1038/onc.2010.394. Epub 2010 Sep 6.

PMID:
20818436
4.
5.

Sequential activation of Snail1 and N-Myc modulates sonic hedgehog-induced transformation of neural cells.

Colvin Wanshura LE, Galvin KE, Ye H, Fernandez-Zapico ME, Wetmore C.

Cancer Res. 2011 Aug 1;71(15):5336-45. doi: 10.1158/0008-5472.CAN-10-2633. Epub 2011 Jun 6.

6.

Concerted microRNA control of Hedgehog signalling in cerebellar neuronal progenitor and tumour cells.

Ferretti E, De Smaele E, Miele E, Laneve P, Po A, Pelloni M, Paganelli A, Di Marcotullio L, Caffarelli E, Screpanti I, Bozzoni I, Gulino A.

EMBO J. 2008 Oct 8;27(19):2616-27. doi: 10.1038/emboj.2008.172. Epub 2008 Aug 28.

7.

Pituitary adenylyl cyclase activating polypeptide inhibits gli1 gene expression and proliferation in primary medulloblastoma derived tumorsphere cultures.

Cohen JR, Resnick DZ, Niewiadomski P, Dong H, Liau LM, Waschek JA.

BMC Cancer. 2010 Dec 9;10:676. doi: 10.1186/1471-2407-10-676.

8.

REN(KCTD11) is a suppressor of Hedgehog signaling and is deleted in human medulloblastoma.

Di Marcotullio L, Ferretti E, De Smaele E, Argenti B, Mincione C, Zazzeroni F, Gallo R, Masuelli L, Napolitano M, Maroder M, Modesti A, Giangaspero F, Screpanti I, Alesse E, Gulino A.

Proc Natl Acad Sci U S A. 2004 Jul 20;101(29):10833-8. Epub 2004 Jul 12.

9.

Histone deacetylase and Cullin3-REN(KCTD11) ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylation.

Canettieri G, Di Marcotullio L, Greco A, Coni S, Antonucci L, Infante P, Pietrosanti L, De Smaele E, Ferretti E, Miele E, Pelloni M, De Simone G, Pedone EM, Gallinari P, Giorgi A, Steinkühler C, Vitagliano L, Pedone C, Schinin ME, Screpanti I, Gulino A.

Nat Cell Biol. 2010 Feb;12(2):132-42. doi: 10.1038/ncb2013. Epub 2010 Jan 17.

PMID:
20081843
10.

PCAF ubiquitin ligase activity inhibits Hedgehog/Gli1 signaling in p53-dependent response to genotoxic stress.

Mazzà D, Infante P, Colicchia V, Greco A, Alfonsi R, Siler M, Antonucci L, Po A, De Smaele E, Ferretti E, Capalbo C, Bellavia D, Canettieri G, Giannini G, Screpanti I, Gulino A, Di Marcotullio L.

Cell Death Differ. 2013 Dec;20(12):1688-97. doi: 10.1038/cdd.2013.120. Epub 2013 Sep 6.

11.

Hedgehog/Gli control by ubiquitination/acetylation interplay.

Gulino A, Di Marcotullio L, Canettieri G, De Smaele E, Screpanti I.

Vitam Horm. 2012;88:211-27. doi: 10.1016/B978-0-12-394622-5.00009-2. Review.

PMID:
22391305
12.

A GLI1-p53 inhibitory loop controls neural stem cell and tumour cell numbers.

Stecca B, Ruiz i Altaba A.

EMBO J. 2009 Mar 18;28(6):663-76. doi: 10.1038/emboj.2009.16. Epub 2009 Feb 12.

13.

RNA editing of the GLI1 transcription factor modulates the output of Hedgehog signaling.

Shimokawa T, Rahman MF, Tostar U, Sonkoly E, Ståhle M, Pivarcsi A, Palaniswamy R, Zaphiropoulos PG.

RNA Biol. 2013 Feb;10(2):321-33. doi: 10.4161/rna.23343. Epub 2013 Jan 16.

14.

β-Catenin-Gli1 interaction regulates proliferation and tumor growth in medulloblastoma.

Zinke J, Schneider FT, Harter PN, Thom S, Ziegler N, Toftgård R, Plate KH, Liebner S.

Mol Cancer. 2015 Feb 3;14:17. doi: 10.1186/s12943-015-0294-4.

15.

Post-transcriptional down-regulation of Atoh1/Math1 by bone morphogenic proteins suppresses medulloblastoma development.

Zhao H, Ayrault O, Zindy F, Kim JH, Roussel MF.

Genes Dev. 2008 Mar 15;22(6):722-7. doi: 10.1101/gad.1636408.

16.

The p53 inhibitor MDM2 facilitates Sonic Hedgehog-mediated tumorigenesis and influences cerebellar foliation.

Malek R, Matta J, Taylor N, Perry ME, Mendrysa SM.

PLoS One. 2011 Mar 18;6(3):e17884. doi: 10.1371/journal.pone.0017884.

17.

Bmi1 is essential for cerebellar development and is overexpressed in human medulloblastomas.

Leung C, Lingbeek M, Shakhova O, Liu J, Tanger E, Saremaslani P, Van Lohuizen M, Marino S.

Nature. 2004 Mar 18;428(6980):337-41.

PMID:
15029199
18.

Suppressor of fused controls mid-hindbrain patterning and cerebellar morphogenesis via GLI3 repressor.

Kim JJ, Gill PS, Rotin L, van Eede M, Henkelman RM, Hui CC, Rosenblum ND.

J Neurosci. 2011 Feb 2;31(5):1825-36. doi: 10.1523/JNEUROSCI.2166-10.2011.

19.

Synergism between Hedgehog-GLI and EGFR signaling in Hedgehog-responsive human medulloblastoma cells induces downregulation of canonical Hedgehog-target genes and stabilized expression of GLI1.

Götschel F, Berg D, Gruber W, Bender C, Eberl M, Friedel M, Sonntag J, Rüngeler E, Hache H, Wierling C, Nietfeld W, Lehrach H, Frischauf A, Schwartz-Albiez R, Aberger F, Korf U.

PLoS One. 2013 Jun 10;8(6):e65403. doi: 10.1371/journal.pone.0065403. Print 2013.

20.

Loss of Pin1 Suppresses Hedgehog-Driven Medulloblastoma Tumorigenesis.

Xu T, Zhang H, Park SS, Venneti S, Kuick R, Ha K, Michael LE, Santi M, Uchida C, Uchida T, Srinivasan A, Olson JM, Dlugosz AA, Camelo-Piragua S, Rual JF.

Neoplasia. 2017 Mar;19(3):216-225. doi: 10.1016/j.neo.2017.01.002. Epub 2017 Feb 3.

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