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Items: 1 to 20 of 90

1.

Phosphoinositide 3-kinase C2alpha links clathrin to microtubule-dependent movement.

Zhao Y, Gaidarov I, Keen JH.

J Biol Chem. 2007 Jan 12;282(2):1249-56. Epub 2006 Nov 15.

2.

Individual phosphoinositide 3-kinase C2alpha domain activities independently regulate clathrin function.

Gaidarov I, Zhao Y, Keen JH.

J Biol Chem. 2005 Dec 9;280(49):40766-72. Epub 2005 Oct 7.

3.
4.

Cytoplasmic dynein/dynactin mediates the assembly of aggresomes.

Johnston JA, Illing ME, Kopito RR.

Cell Motil Cytoskeleton. 2002 Sep;53(1):26-38.

PMID:
12211113
5.

Ca2+-regulated pool of phosphatidylinositol-3-phosphate produced by phosphatidylinositol 3-kinase C2alpha on neurosecretory vesicles.

Wen PJ, Osborne SL, Morrow IC, Parton RG, Domin J, Meunier FA.

Mol Biol Cell. 2008 Dec;19(12):5593-603. doi: 10.1091/mbc.E08-06-0595. Epub 2008 Oct 8.

6.

Endothelial PI3K-C2α, a class II PI3K, has an essential role in angiogenesis and vascular barrier function.

Yoshioka K, Yoshida K, Cui H, Wakayama T, Takuwa N, Okamoto Y, Du W, Qi X, Asanuma K, Sugihara K, Aki S, Miyazawa H, Biswas K, Nagakura C, Ueno M, Iseki S, Schwartz RJ, Okamoto H, Sasaki T, Matsui O, Asano M, Adams RH, Takakura N, Takuwa Y.

Nat Med. 2012 Oct;18(10):1560-9. doi: 10.1038/nm.2928. Epub 2012 Sep 16.

PMID:
22983395
7.

Phosphatidylinositol 3-kinase C2alpha is essential for ATP-dependent priming of neurosecretory granule exocytosis.

Meunier FA, Osborne SL, Hammond GR, Cooke FT, Parker PJ, Domin J, Schiavo G.

Mol Biol Cell. 2005 Oct;16(10):4841-51. Epub 2005 Jul 29.

8.

Phosphatidylinositol 3-kinase class II α-isoform PI3K-C2α is required for transforming growth factor β-induced Smad signaling in endothelial cells.

Aki S, Yoshioka K, Okamoto Y, Takuwa N, Takuwa Y.

J Biol Chem. 2015 Mar 6;290(10):6086-105. doi: 10.1074/jbc.M114.601484. Epub 2015 Jan 22.

9.

The class II phosphoinositide 3-kinase PI3K-C2alpha is concentrated in the trans-Golgi network and present in clathrin-coated vesicles.

Domin J, Gaidarov I, Smith ME, Keen JH, Waterfield MD.

J Biol Chem. 2000 Apr 21;275(16):11943-50.

10.

Insulin-feedback via PI3K-C2alpha activated PKBalpha/Akt1 is required for glucose-stimulated insulin secretion.

Leibiger B, Moede T, Uhles S, Barker CJ, Creveaux M, Domin J, Berggren PO, Leibiger IB.

FASEB J. 2010 Jun;24(6):1824-37. doi: 10.1096/fj.09-148072. Epub 2010 Jan 8.

PMID:
20061534
11.

Enhanced Ca2+-dependent activation of phosphoinositide 3-kinase class IIα isoform-Rho axis in blood vessels of spontaneously hypertensive rats.

Seok YM, Azam MA, Okamoto Y, Sato A, Yoshioka K, Maeda M, Kim I, Takuwa Y.

Hypertension. 2010 Nov;56(5):934-41. doi: 10.1161/HYPERTENSIONAHA.110.160853. Epub 2010 Oct 4.

12.

Class II phosphoinositide 3-kinase alpha-isoform regulates Rho, myosin phosphatase and contraction in vascular smooth muscle.

Wang Y, Yoshioka K, Azam MA, Takuwa N, Sakurada S, Kayaba Y, Sugimoto N, Inoki I, Kimura T, Kuwaki T, Takuwa Y.

Biochem J. 2006 Mar 15;394(Pt 3):581-92.

13.

Phosphoinositide 3-kinase regulates beta2-adrenergic receptor endocytosis by AP-2 recruitment to the receptor/beta-arrestin complex.

Naga Prasad SV, Laporte SA, Chamberlain D, Caron MG, Barak L, Rockman HA.

J Cell Biol. 2002 Aug 5;158(3):563-75. Epub 2002 Aug 5.

14.

Structural and membrane binding analysis of the Phox homology domain of phosphoinositide 3-kinase-C2alpha.

Stahelin RV, Karathanassis D, Bruzik KS, Waterfield MD, Bravo J, Williams RL, Cho W.

J Biol Chem. 2006 Dec 22;281(51):39396-406. Epub 2006 Oct 12.

15.

Mitotic and stress-induced phosphorylation of HsPI3K-C2alpha targets the protein for degradation.

Didichenko SA, Fragoso CM, Thelen M.

J Biol Chem. 2003 Jul 11;278(28):26055-64. Epub 2003 Apr 28.

17.

Dynactin increases the processivity of the cytoplasmic dynein motor.

King SJ, Schroer TA.

Nat Cell Biol. 2000 Jan;2(1):20-4.

PMID:
10620802
18.

Phosphoinositide 3-Kinase-C2α Regulates Polycystin-2 Ciliary Entry and Protects against Kidney Cyst Formation.

Franco I, Margaria JP, De Santis MC, Ranghino A, Monteyne D, Chiaravalli M, Pema M, Campa CC, Ratto E, Gulluni F, Perez-Morga D, Somlo S, Merlo GR, Boletta A, Hirsch E.

J Am Soc Nephrol. 2016 Apr;27(4):1135-44. doi: 10.1681/ASN.2014100967. Epub 2015 Aug 13.

PMID:
26271513
19.

Dynein-dynactin complex mediates protein kinase A-dependent clustering of Weibel-Palade bodies in endothelial cells.

Rondaij MG, Bierings R, Kragt A, Gijzen KA, Sellink E, van Mourik JA, Fernandez-Borja M, Voorberg J.

Arterioscler Thromb Vasc Biol. 2006 Jan;26(1):49-55. Epub 2005 Oct 20.

20.

Colocalization of cytoplasmic dynein with dynactin and CLIP-170 at microtubule distal ends.

Vaughan KT, Tynan SH, Faulkner NE, Echeverri CJ, Vallee RB.

J Cell Sci. 1999 May;112 ( Pt 10):1437-47.

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