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Items: 1 to 20 of 107

1.

DTL/CDT2 is essential for both CDT1 regulation and the early G2/M checkpoint.

Sansam CL, Shepard JL, Lai K, Ianari A, Danielian PS, Amsterdam A, Hopkins N, Lees JA.

Genes Dev. 2006 Nov 15;20(22):3117-29. Epub 2006 Nov 3.

2.
3.

L2DTL/CDT2 interacts with the CUL4/DDB1 complex and PCNA and regulates CDT1 proteolysis in response to DNA damage.

Higa LA, Banks D, Wu M, Kobayashi R, Sun H, Zhang H.

Cell Cycle. 2006 Aug;5(15):1675-80. Epub 2006 Aug 1.

PMID:
16861906
4.

Two E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for proteolysis.

Nishitani H, Sugimoto N, Roukos V, Nakanishi Y, Saijo M, Obuse C, Tsurimoto T, Nakayama KI, Nakayama K, Fujita M, Lygerou Z, Nishimoto T.

EMBO J. 2006 Mar 8;25(5):1126-36. Epub 2006 Feb 16.

5.

DNA damage induces Cdt1 proteolysis in fission yeast through a pathway dependent on Cdt2 and Ddb1.

Ralph E, Boye E, Kearsey SE.

EMBO Rep. 2006 Nov;7(11):1134-9. Epub 2006 Oct 13. Erratum in: EMBO Rep. 2007 Feb;8(2):200.

6.

DDB1 maintains genome integrity through regulation of Cdt1.

Lovejoy CA, Lock K, Yenamandra A, Cortez D.

Mol Cell Biol. 2006 Nov;26(21):7977-90. Epub 2006 Aug 28.

7.

Cell type-dependent requirement for PIP box-regulated Cdt1 destruction during S phase.

Lee HO, Zacharek SJ, Xiong Y, Duronio RJ.

Mol Biol Cell. 2010 Nov 1;21(21):3639-53. doi: 10.1091/mbc.E10-02-0130. Epub 2010 Sep 8.

8.

CRL4(CDT2) targets CHK1 for PCNA-independent destruction.

Huh J, Piwnica-Worms H.

Mol Cell Biol. 2013 Jan;33(2):213-26. doi: 10.1128/MCB.00847-12. Epub 2012 Oct 29.

9.

Checkpoint kinase ATR phosphorylates Cdt2, a substrate receptor of CRL4 ubiquitin ligase, and promotes the degradation of Cdt1 following UV irradiation.

Sakaguchi H, Takami T, Yasutani Y, Maeda T, Morino M, Ishii T, Shiomi Y, Nishitani H.

PLoS One. 2012;7(9):e46480. doi: 10.1371/journal.pone.0046480. Epub 2012 Sep 28.

10.

Stress-stimulated mitogen-activated protein kinases control the stability and activity of the Cdt1 DNA replication licensing factor.

Chandrasekaran S, Tan TX, Hall JR, Cook JG.

Mol Cell Biol. 2011 Nov;31(22):4405-16. doi: 10.1128/MCB.06163-11. Epub 2011 Sep 19.

11.

CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation.

Higa LA, Wu M, Ye T, Kobayashi R, Sun H, Zhang H.

Nat Cell Biol. 2006 Nov;8(11):1277-83. Epub 2006 Oct 15.

PMID:
17041588
12.

Rereplication in emi1-deficient zebrafish embryos occurs through a Cdh1-mediated pathway.

Robu ME, Zhang Y, Rhodes J.

PLoS One. 2012;7(10):e47658. doi: 10.1371/journal.pone.0047658. Epub 2012 Oct 17.

14.

Cdt1 and Cdc6 are destabilized by rereplication-induced DNA damage.

Hall JR, Lee HO, Bunker BD, Dorn ES, Rogers GC, Duronio RJ, Cook JG.

J Biol Chem. 2008 Sep 12;283(37):25356-63. doi: 10.1074/jbc.M802667200. Epub 2008 Jul 10.

15.

Lentiviral Vpr usurps Cul4-DDB1[VprBP] E3 ubiquitin ligase to modulate cell cycle.

Hrecka K, Gierszewska M, Srivastava S, Kozaczkiewicz L, Swanson SK, Florens L, Washburn MP, Skowronski J.

Proc Natl Acad Sci U S A. 2007 Jul 10;104(28):11778-83. Epub 2007 Jul 3.

16.

Inactivation of the CRL4-CDT2-SET8/p21 ubiquitylation and degradation axis underlies the therapeutic efficacy of pevonedistat in melanoma.

Benamar M, Guessous F, Du K, Corbett P, Obeid J, Gioeli D, Slingluff CL Jr, Abbas T.

EBioMedicine. 2016 Aug;10:85-100. doi: 10.1016/j.ebiom.2016.06.023. Epub 2016 Jun 16.

17.

PCNA is a cofactor for Cdt1 degradation by CUL4/DDB1-mediated N-terminal ubiquitination.

Senga T, Sivaprasad U, Zhu W, Park JH, Arias EE, Walter JC, Dutta A.

J Biol Chem. 2006 Mar 10;281(10):6246-52. Epub 2006 Jan 9.

18.

Mitotic UV irradiation induces a DNA replication-licensing defect that potentiates G1 arrest response.

Morino M, Nukina K, Sakaguchi H, Maeda T, Takahara M, Shiomi Y, Nishitani H.

PLoS One. 2015 Mar 23;10(3):e0120553. doi: 10.1371/journal.pone.0120553. eCollection 2015.

19.

Selective ubiquitylation of p21 and Cdt1 by UBCH8 and UBE2G ubiquitin-conjugating enzymes via the CRL4Cdt2 ubiquitin ligase complex.

Shibata E, Abbas T, Huang X, Wohlschlegel JA, Dutta A.

Mol Cell Biol. 2011 Aug;31(15):3136-45. doi: 10.1128/MCB.05496-11. Epub 2011 May 31.

20.

L2DTL/CDT2 and PCNA interact with p53 and regulate p53 polyubiquitination and protein stability through MDM2 and CUL4A/DDB1 complexes.

Banks D, Wu M, Higa LA, Gavrilova N, Quan J, Ye T, Kobayashi R, Sun H, Zhang H.

Cell Cycle. 2006 Aug;5(15):1719-29. Epub 2006 Aug 1.

PMID:
16861890

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