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Items: 1 to 20 of 239

1.

Conditional deletion of Nbs1 in murine cells reveals its role in branching repair pathways of DNA double-strand breaks.

Yang YG, Saidi A, Frappart PO, Min W, Barrucand C, Dumon-Jones V, Michelon J, Herceg Z, Wang ZQ.

EMBO J. 2006 Nov 29;25(23):5527-38. Epub 2006 Nov 2.

2.

The role of the Mre11-Rad50-Nbs1 complex in double-strand break repair-facts and myths.

Takeda S, Hoa NN, Sasanuma H.

J Radiat Res. 2016 Aug;57 Suppl 1:i25-i32. doi: 10.1093/jrr/rrw034. Epub 2016 Jun 15.

3.

MRE11-RAD50-NBS1 complex dictates DNA repair independent of H2AX.

Yuan J, Chen J.

J Biol Chem. 2010 Jan 8;285(2):1097-104. doi: 10.1074/jbc.M109.078436. Epub 2009 Nov 12.

4.

Mre11-Rad50-Nbs1 is a keystone complex connecting DNA repair machinery, double-strand break signaling, and the chromatin template.

Williams RS, Williams JS, Tainer JA.

Biochem Cell Biol. 2007 Aug;85(4):509-20. Review.

PMID:
17713585
5.

Impaired DNA double strand break repair in cells from Nijmegen breakage syndrome patients.

Howlett NG, Scuric Z, D'Andrea AD, Schiestl RH.

DNA Repair (Amst). 2006 Feb 3;5(2):251-7. Epub 2005 Nov 22.

PMID:
16309973
6.

MRN complex function in the repair of chromosomal Rag-mediated DNA double-strand breaks.

Helmink BA, Bredemeyer AL, Lee BS, Huang CY, Sharma GG, Walker LM, Bednarski JJ, Lee WL, Pandita TK, Bassing CH, Sleckman BP.

J Exp Med. 2009 Mar 16;206(3):669-79. doi: 10.1084/jem.20081326. Epub 2009 Feb 16.

7.

MCM8-9 complex promotes resection of double-strand break ends by MRE11-RAD50-NBS1 complex.

Lee KY, Im JS, Shibata E, Park J, Handa N, Kowalczykowski SC, Dutta A.

Nat Commun. 2015 Jul 28;6:7744. doi: 10.1038/ncomms8744.

8.

Single-Molecule Imaging Reveals How Mre11-Rad50-Nbs1 Initiates DNA Break Repair.

Myler LR, Gallardo IF, Soniat MM, Deshpande RA, Gonzalez XB, Kim Y, Paull TT, Finkelstein IJ.

Mol Cell. 2017 Sep 7;67(5):891-898.e4. doi: 10.1016/j.molcel.2017.08.002. Epub 2017 Aug 31.

PMID:
28867292
9.

Breast cancer risk is associated with the genes encoding the DNA double-strand break repair Mre11/Rad50/Nbs1 complex.

Hsu HM, Wang HC, Chen ST, Hsu GC, Shen CY, Yu JC.

Cancer Epidemiol Biomarkers Prev. 2007 Oct;16(10):2024-32.

10.

Smad7 enhances ATM activity by facilitating the interaction between ATM and Mre11-Rad50-Nbs1 complex in DNA double-strand break repair.

Park S, Kang JM, Kim SJ, Kim H, Hong S, Lee YJ, Kim SJ.

Cell Mol Life Sci. 2015 Feb;72(3):583-96. doi: 10.1007/s00018-014-1687-z. Epub 2014 Jul 26.

PMID:
25063542
11.

Roles for NBS1 in alternative nonhomologous end-joining of V(D)J recombination intermediates.

Deriano L, Stracker TH, Baker A, Petrini JH, Roth DB.

Mol Cell. 2009 Apr 10;34(1):13-25. doi: 10.1016/j.molcel.2009.03.009.

12.

The transcriptional histone acetyltransferase cofactor TRRAP associates with the MRN repair complex and plays a role in DNA double-strand break repair.

Robert F, Hardy S, Nagy Z, Baldeyron C, Murr R, Déry U, Masson JY, Papadopoulo D, Herceg Z, Tora L.

Mol Cell Biol. 2006 Jan;26(2):402-12.

13.

Genetic steps of mammalian homologous repair with distinct mutagenic consequences.

Stark JM, Pierce AJ, Oh J, Pastink A, Jasin M.

Mol Cell Biol. 2004 Nov;24(21):9305-16.

14.

Cdk1 uncouples CtIP-dependent resection and Rad51 filament formation during M-phase double-strand break repair.

Peterson SE, Li Y, Chait BT, Gottesman ME, Baer R, Gautier J.

J Cell Biol. 2011 Sep 5;194(5):705-20. doi: 10.1083/jcb.201103103.

15.
16.

Cell cycle-dependent complex formation of BRCA1.CtIP.MRN is important for DNA double-strand break repair.

Chen L, Nievera CJ, Lee AY, Wu X.

J Biol Chem. 2008 Mar 21;283(12):7713-20. doi: 10.1074/jbc.M710245200. Epub 2008 Jan 2.

17.

Alternative-NHEJ is a mechanistically distinct pathway of mammalian chromosome break repair.

Bennardo N, Cheng A, Huang N, Stark JM.

PLoS Genet. 2008 Jun 27;4(6):e1000110. doi: 10.1371/journal.pgen.1000110.

18.

The essential function of the MRN complex in the resolution of endogenous replication intermediates.

Bruhn C, Zhou ZW, Ai H, Wang ZQ.

Cell Rep. 2014 Jan 16;6(1):182-95. doi: 10.1016/j.celrep.2013.12.018. Epub 2014 Jan 2.

19.

Repair of double-strand breaks by nonhomologous end joining in the absence of Mre11.

Di Virgilio M, Gautier J.

J Cell Biol. 2005 Dec 5;171(5):765-71.

20.

Hierarchy of nonhomologous end-joining, single-strand annealing and gene conversion at site-directed DNA double-strand breaks.

Mansour WY, Schumacher S, Rosskopf R, Rhein T, Schmidt-Petersen F, Gatzemeier F, Haag F, Borgmann K, Willers H, Dahm-Daphi J.

Nucleic Acids Res. 2008 Jul;36(12):4088-98. doi: 10.1093/nar/gkn347. Epub 2008 Jun 6.

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