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Items: 1 to 20 of 167


The BRCA1/BARD1 heterodimer modulates ran-dependent mitotic spindle assembly.

Joukov V, Groen AC, Prokhorova T, Gerson R, White E, Rodriguez A, Walter JC, Livingston DM.

Cell. 2006 Nov 3;127(3):539-52.


A mitotic role for BRCA1/BARD1 in tumor suppression?

Clarke PR, Sanderson HS.

Cell. 2006 Nov 3;127(3):453-5.


Ran modulates spindle assembly by regulating a subset of TPX2 and Kid activities including Aurora A activation.

Trieselmann N, Armstrong S, Rauw J, Wilde A.

J Cell Sci. 2003 Dec 1;116(Pt 23):4791-8.


XRHAMM functions in ran-dependent microtubule nucleation and pole formation during anastral spindle assembly.

Groen AC, Cameron LA, Coughlin M, Miyamoto DT, Mitchison TJ, Ohi R.

Curr Biol. 2004 Oct 26;14(20):1801-11.


TPX2 levels modulate meiotic spindle size and architecture in Xenopus egg extracts.

Helmke KJ, Heald R.

J Cell Biol. 2014 Aug 4;206(3):385-93. doi: 10.1083/jcb.201401014. Epub 2014 Jul 28.


Characterization of the TPX2 domains involved in microtubule nucleation and spindle assembly in Xenopus egg extracts.

Brunet S, Sardon T, Zimmerman T, Wittmann T, Pepperkok R, Karsenti E, Vernos I.

Mol Biol Cell. 2004 Dec;15(12):5318-28. Epub 2004 Sep 22.


Importin beta is transported to spindle poles during mitosis and regulates Ran-dependent spindle assembly factors in mammalian cells.

Ciciarello M, Mangiacasale R, Thibier C, Guarguaglini G, Marchetti E, Di Fiore B, Lavia P.

J Cell Sci. 2004 Dec 15;117(Pt 26):6511-22. Epub 2004 Nov 30.


Cdk11 is a RanGTP-dependent microtubule stabilization factor that regulates spindle assembly rate.

Yokoyama H, Gruss OJ, Rybina S, Caudron M, Schelder M, Wilm M, Mattaj IW, Karsenti E.

J Cell Biol. 2008 Mar 10;180(5):867-75. doi: 10.1083/jcb.200706189. Epub 2008 Mar 3.


Regulated degradation of spindle assembly factors by the anaphase-promoting complex.

Song L, Rape M.

Mol Cell. 2010 May 14;38(3):369-82. doi: 10.1016/j.molcel.2010.02.038.


Ran induces spindle assembly by reversing the inhibitory effect of importin alpha on TPX2 activity.

Gruss OJ, Carazo-Salas RE, Schatz CA, Guarguaglini G, Kast J, Wilm M, Le Bot N, Vernos I, Karsenti E, Mattaj IW.

Cell. 2001 Jan 12;104(1):83-93.


TPX2, A novel xenopus MAP involved in spindle pole organization.

Wittmann T, Wilm M, Karsenti E, Vernos I.

J Cell Biol. 2000 Jun 26;149(7):1405-18.


A survivin-ran complex regulates spindle formation in tumor cells.

Xia F, Canovas PM, Guadagno TM, Altieri DC.

Mol Cell Biol. 2008 Sep;28(17):5299-311. doi: 10.1128/MCB.02039-07. Epub 2008 Jun 30.


Dissecting the role of Aurora A during spindle assembly.

Sardon T, Peset I, Petrova B, Vernos I.

EMBO J. 2008 Oct 8;27(19):2567-79. doi: 10.1038/emboj.2008.173. Epub 2008 Aug 28. Erratum in: EMBO J. 2008 Nov 5;27(21):2942.


Distinct roles of BARD1 isoforms in mitosis: full-length BARD1 mediates Aurora B degradation, cancer-associated BARD1beta scaffolds Aurora B and BRCA2.

Ryser S, Dizin E, Jefford CE, Delaval B, Gagos S, Christodoulidou A, Krause KH, Birnbaum D, Irminger-Finger I.

Cancer Res. 2009 Feb 1;69(3):1125-34. doi: 10.1158/0008-5472.CAN-08-2134. Epub 2009 Jan 27.


BRCA1 DNA-binding activity is stimulated by BARD1.

Simons AM, Horwitz AA, Starita LM, Griffin K, Williams RS, Glover JN, Parvin JD.

Cancer Res. 2006 Feb 15;66(4):2012-8.


Hepatoma up-regulated protein is required for chromatin-induced microtubule assembly independently of TPX2.

Casanova CM, Rybina S, Yokoyama H, Karsenti E, Mattaj IW.

Mol Biol Cell. 2008 Nov;19(11):4900-8. doi: 10.1091/mbc.E08-06-0624. Epub 2008 Sep 17.


A Ran signalling pathway mediated by the mitotic kinase Aurora A in spindle assembly.

Tsai MY, Wiese C, Cao K, Martin O, Donovan P, Ruderman J, Prigent C, Zheng Y.

Nat Cell Biol. 2003 Mar;5(3):242-8.


The basal-like mammary carcinomas induced by Brca1 or Bard1 inactivation implicate the BRCA1/BARD1 heterodimer in tumor suppression.

Shakya R, Szabolcs M, McCarthy E, Ospina E, Basso K, Nandula S, Murty V, Baer R, Ludwig T.

Proc Natl Acad Sci U S A. 2008 May 13;105(19):7040-5. doi: 10.1073/pnas.0711032105. Epub 2008 Apr 28.


Characterization of BRCA1 protein targeting, dynamics, and function at the centrosome: a role for the nuclear export signal, CRM1, and Aurora A kinase.

Brodie KM, Henderson BR.

J Biol Chem. 2012 Mar 2;287(10):7701-16. doi: 10.1074/jbc.M111.327296. Epub 2012 Jan 18.

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