Sort by
Items per page

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 120


Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators.

St-Pierre J, Drori S, Uldry M, Silvaggi JM, Rhee J, Jäger S, Handschin C, Zheng K, Lin J, Yang W, Simon DK, Bachoo R, Spiegelman BM.

Cell. 2006 Oct 20;127(2):397-408.


Sirtuin 3, a new target of PGC-1alpha, plays an important role in the suppression of ROS and mitochondrial biogenesis.

Kong X, Wang R, Xue Y, Liu X, Zhang H, Chen Y, Fang F, Chang Y.

PLoS One. 2010 Jul 22;5(7):e11707. doi: 10.1371/journal.pone.0011707.


Interactions between ROS and AMP kinase activity in the regulation of PGC-1alpha transcription in skeletal muscle cells.

Irrcher I, Ljubicic V, Hood DA.

Am J Physiol Cell Physiol. 2009 Jan;296(1):C116-23. doi: 10.1152/ajpcell.00267.2007. Epub 2008 Nov 12.


The role of PGC-1alpha on mitochondrial function and apoptotic susceptibility in muscle.

Adhihetty PJ, Uguccioni G, Leick L, Hidalgo J, Pilegaard H, Hood DA.

Am J Physiol Cell Physiol. 2009 Jul;297(1):C217-25. doi: 10.1152/ajpcell.00070.2009. Epub 2009 May 13.


Epigallocatechin-3-gallate suppresses 1-methyl-4-phenyl-pyridine-induced oxidative stress in PC12 cells via the SIRT1/PGC-1α signaling pathway.

Ye Q, Ye L, Xu X, Huang B, Zhang X, Zhu Y, Chen X.

BMC Complement Altern Med. 2012 Jun 28;12:82. doi: 10.1186/1472-6882-12-82.


Peroxisome proliferator-activated receptor γ, coactivator 1α deletion induces angiotensin II-associated vascular dysfunction by increasing mitochondrial oxidative stress and vascular inflammation.

Kröller-Schön S, Jansen T, Schüler A, Oelze M, Wenzel P, Hausding M, Kerahrodi JG, Beisele M, Lackner KJ, Daiber A, Münzel T, Schulz E.

Arterioscler Thromb Vasc Biol. 2013 Aug;33(8):1928-35. doi: 10.1161/ATVBAHA.113.301717. Epub 2013 Jun 20.


Transcriptional control of mitochondrial energy metabolism through the PGC1 coactivators.

Spiegelman BM.

Novartis Found Symp. 2007;287:60-3; discussion 63-9. Review.


Transducer of regulated CREB-binding proteins (TORCs) induce PGC-1alpha transcription and mitochondrial biogenesis in muscle cells.

Wu Z, Huang X, Feng Y, Handschin C, Feng Y, Gullicksen PS, Bare O, Labow M, Spiegelman B, Stevenson SC.

Proc Natl Acad Sci U S A. 2006 Sep 26;103(39):14379-84. Epub 2006 Sep 15.


Inhibition of PGC-1α after chemotherapy-mediated insult confines multiple myeloma cell survival by affecting ROS accumulation.

Cao D, Jin L, Zhou H, Yu W, Hu Y, Guo T.

Oncol Rep. 2015 Feb;33(2):899-904. doi: 10.3892/or.2014.3635. Epub 2014 Nov 28.


Pyrroloquinoline quinone stimulates mitochondrial biogenesis through cAMP response element-binding protein phosphorylation and increased PGC-1alpha expression.

Chowanadisai W, Bauerly KA, Tchaparian E, Wong A, Cortopassi GA, Rucker RB.

J Biol Chem. 2010 Jan 1;285(1):142-52. doi: 10.1074/jbc.M109.030130. Epub 2009 Oct 27.


Impact of PGC-1α on the topology and rate of superoxide production by the mitochondrial electron transport chain.

Austin S, Klimcakova E, St-Pierre J.

Free Radic Biol Med. 2011 Dec 15;51(12):2243-8. doi: 10.1016/j.freeradbiomed.2011.08.036. Epub 2011 Sep 10.


Transcriptional control of energy homeostasis through the PGC1 coactivators.

Spiegelman BM.

Novartis Found Symp. 2007;286:3-6; discusssion 6-12, 162-3, 196-203.


αvβ5 Integrin/FAK/PGC-1α Pathway Confers Protective Effects on Retinal Pigment Epithelium.

Roggia MF, Ueta T.

PLoS One. 2015 Aug 5;10(8):e0134870. doi: 10.1371/journal.pone.0134870. eCollection 2015.


Transgenic expression and activation of PGC-1α protect dopaminergic neurons in the MPTP mouse model of Parkinson's disease.

Mudò G, Mäkelä J, Di Liberto V, Tselykh TV, Olivieri M, Piepponen P, Eriksson O, Mälkiä A, Bonomo A, Kairisalo M, Aguirre JA, Korhonen L, Belluardo N, Lindholm D.

Cell Mol Life Sci. 2012 Apr;69(7):1153-65. doi: 10.1007/s00018-011-0850-z. Epub 2011 Oct 8.


Acetylcholine promotes ROS detoxification against hypoxia/reoxygenation-induced oxidative stress through FoxO3a/PGC-1α dependent superoxide dismutase.

Sun L, Zang WJ, Wang H, Zhao M, Yu XJ, He X, Miao Y, Zhou J.

Cell Physiol Biochem. 2014;34(5):1614-25. doi: 10.1159/000366364. Epub 2014 Nov 3. Erratum in: Cell Physiol Biochem. 2015;36(5):2083.


PGC-1alpha down-regulation affects the antioxidant response in Friedreich's ataxia.

Marmolino D, Manto M, Acquaviva F, Vergara P, Ravella A, Monticelli A, Pandolfo M.

PLoS One. 2010 Apr 7;5(4):e10025. doi: 10.1371/journal.pone.0010025.


Aluminium induced oxidative stress results in decreased mitochondrial biogenesis via modulation of PGC-1α expression.

Sharma DR, Sunkaria A, Wani WY, Sharma RK, Kandimalla RJ, Bal A, Gill KD.

Toxicol Appl Pharmacol. 2013 Dec 1;273(2):365-80. doi: 10.1016/j.taap.2013.09.012. Epub 2013 Sep 29.


PGC-1 alpha regulates expression of myocardial mitochondrial antioxidants and myocardial oxidative stress after chronic systolic overload.

Lu Z, Xu X, Hu X, Fassett J, Zhu G, Tao Y, Li J, Huang Y, Zhang P, Zhao B, Chen Y.

Antioxid Redox Signal. 2010 Oct 1;13(7):1011-22. doi: 10.1089/ars.2009.2940.


PGC-1alpha, a new therapeutic target in Huntington's disease?

McGill JK, Beal MF.

Cell. 2006 Nov 3;127(3):465-8. Review.

Supplemental Content

Support Center