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Items: 1 to 20 of 153


A stapled BID BH3 helix directly binds and activates BAX.

Walensky LD, Pitter K, Morash J, Oh KJ, Barbuto S, Fisher J, Smith E, Verdine GL, Korsmeyer SJ.

Mol Cell. 2006 Oct 20;24(2):199-210.


A membrane-targeted BID BCL-2 homology 3 peptide is sufficient for high potency activation of BAX in vitro.

Oh KJ, Barbuto S, Pitter K, Morash J, Walensky LD, Korsmeyer SJ.

J Biol Chem. 2006 Dec 1;281(48):36999-7008.


BH3-only activator proteins Bid and Bim are dispensable for Bak/Bax-dependent thrombocyte apoptosis induced by Bcl-xL deficiency: molecular requisites for the mitochondrial pathway to apoptosis in platelets.

Kodama T, Takehara T, Hikita H, Shimizu S, Shigekawa M, Li W, Miyagi T, Hosui A, Tatsumi T, Ishida H, Kanto T, Hiramatsu N, Yin XM, Hayashi N.

J Biol Chem. 2011 Apr 22;286(16):13905-13. doi: 10.1074/jbc.M110.195370.


The first alpha helix of Bax plays a necessary role in its ligand-induced activation by the BH3-only proteins Bid and PUMA.

Cartron PF, Gallenne T, Bougras G, Gautier F, Manero F, Vusio P, Meflah K, Vallette FM, Juin P.

Mol Cell. 2004 Dec 3;16(5):807-18.


BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly.

Kuwana T, Bouchier-Hayes L, Chipuk JE, Bonzon C, Sullivan BA, Green DR, Newmeyer DD.

Mol Cell. 2005 Feb 18;17(4):525-35.


Bid: a Bax-like BH3 protein.

Billen LP, Shamas-Din A, Andrews DW.

Oncogene. 2008 Dec;27 Suppl 1:S93-104. doi: 10.1038/onc.2009.47. Review.


BID: a novel BH3 domain-only death agonist.

Wang K, Yin XM, Chao DT, Milliman CL, Korsmeyer SJ.

Genes Dev. 1996 Nov 15;10(22):2859-69.


Structural biology of the Bcl-2 family of proteins.

Petros AM, Olejniczak ET, Fesik SW.

Biochim Biophys Acta. 2004 Mar 1;1644(2-3):83-94. Review.


BIM and tBID are not mechanistically equivalent when assisting BAX to permeabilize bilayer membranes.

Terrones O, Etxebarria A, Landajuela A, Landeta O, Antonsson B, Basañez G.

J Biol Chem. 2008 Mar 21;283(12):7790-803. doi: 10.1074/jbc.M708814200.


Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics.

Letai A, Bassik MC, Walensky LD, Sorcinelli MD, Weiler S, Korsmeyer SJ.

Cancer Cell. 2002 Sep;2(3):183-92.


Membrane-insertion fragments of Bcl-xL, Bax, and Bid.

García-Sáez AJ, Mingarro I, Pérez-Payá E, Salgado J.

Biochemistry. 2004 Aug 31;43(34):10930-43.


Inhibition of Bax-induced cytochrome c release from neural cell and brain mitochondria by dibucaine and propranolol.

Polster BM, Basañez G, Young M, Suzuki M, Fiskum G.

J Neurosci. 2003 Apr 1;23(7):2735-43.


Minimal BH3 peptides promote cell death by antagonizing anti-apoptotic proteins.

Moreau C, Cartron PF, Hunt A, Meflah K, Green DR, Evan G, Vallette FM, Juin P.

J Biol Chem. 2003 May 23;278(21):19426-35.


Direct addition of BimL to mitochondria does not lead to cytochrome c release.

Terradillos O, Montessuit S, Huang DC, Martinou JC.

FEBS Lett. 2002 Jul 3;522(1-3):29-34.


tBid elicits a conformational alteration in membrane-bound Bcl-2 such that it inhibits Bax pore formation.

Peng J, Tan C, Roberts GJ, Nikolaeva O, Zhang Z, Lapolla SM, Primorac S, Andrews DW, Lin J.

J Biol Chem. 2006 Nov 24;281(47):35802-11.


Examining BCL-2 family function with large unilamellar vesicles.

Asciolla JJ, Renault TT, Chipuk JE.

J Vis Exp. 2012 Oct 5;(68). pii: 4291. doi: 10.3791/4291.


Mapping the specific cytoprotective interaction of humanin with the pro-apoptotic protein bid.

Choi J, Zhai D, Zhou X, Satterthwait A, Reed JC, Marassi FM.

Chem Biol Drug Des. 2007 Nov;70(5):383-92.


The BH3 alpha-helical mimic BH3-M6 disrupts Bcl-X(L), Bcl-2, and MCL-1 protein-protein interactions with Bax, Bak, Bad, or Bim and induces apoptosis in a Bax- and Bim-dependent manner.

Kazi A, Sun J, Doi K, Sung SS, Takahashi Y, Yin H, Rodriguez JM, Becerril J, Berndt N, Hamilton AD, Wang HG, Sebti SM.

J Biol Chem. 2011 Mar 18;286(11):9382-92. doi: 10.1074/jbc.M110.203638.

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