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Sirtuin regulates cigarette smoke-induced proinflammatory mediator release via RelA/p65 NF-kappaB in macrophages in vitro and in rat lungs in vivo: implications for chronic inflammation and aging.

Yang SR, Wright J, Bauter M, Seweryniak K, Kode A, Rahman I.

Am J Physiol Lung Cell Mol Physiol. 2007 Feb;292(2):L567-76. Epub 2006 Oct 13.


SIRT1, an antiinflammatory and antiaging protein, is decreased in lungs of patients with chronic obstructive pulmonary disease.

Rajendrasozhan S, Yang SR, Kinnula VL, Rahman I.

Am J Respir Crit Care Med. 2008 Apr 15;177(8):861-70. doi: 10.1164/rccm.200708-1269OC. Epub 2008 Jan 3.


The peroxisome proliferator-activated receptor β/δ (PPARβ/δ) agonist GW501516 prevents TNF-α-induced NF-κB activation in human HaCaT cells by reducing p65 acetylation through AMPK and SIRT1.

Barroso E, Eyre E, Palomer X, Vázquez-Carrera M.

Biochem Pharmacol. 2011 Feb 15;81(4):534-43. doi: 10.1016/j.bcp.2010.12.004. Epub 2010 Dec 10.


Role of SIRT1 in regulation of LPS- or two ethanol metabolites-induced TNF-alpha production in cultured macrophage cell lines.

Shen Z, Ajmo JM, Rogers CQ, Liang X, Le L, Murr MM, Peng Y, You M.

Am J Physiol Gastrointest Liver Physiol. 2009 May;296(5):G1047-53. doi: 10.1152/ajpgi.00016.2009. Epub 2009 Mar 19.


Inhibition of interleukin-1beta reduces mouse lung inflammation induced by exposure to cigarette smoke.

Castro P, Legora-Machado A, Cardilo-Reis L, Valença S, Porto LC, Walker C, Zuany-Amorim C, Koatz VL.

Eur J Pharmacol. 2004 Sep 13;498(1-3):279-86.


Involvement of the p65/RelA subunit of NF-kappaB in TNF-alpha-induced SIRT1 expression in vascular smooth muscle cells.

Zhang HN, Li L, Gao P, Chen HZ, Zhang R, Wei YS, Liu DP, Liang CC.

Biochem Biophys Res Commun. 2010 Jul 2;397(3):569-75. doi: 10.1016/j.bbrc.2010.05.160.


Epigallocatechin-3-gallate, a histone acetyltransferase inhibitor, inhibits EBV-induced B lymphocyte transformation via suppression of RelA acetylation.

Choi KC, Jung MG, Lee YH, Yoon JC, Kwon SH, Kang HB, Kim MJ, Cha JH, Kim YJ, Jun WJ, Lee JM, Yoon HG.

Cancer Res. 2009 Jan 15;69(2):583-92. doi: 10.1158/0008-5472.CAN-08-2442.


Cigarette smoke alters chromatin remodeling and induces proinflammatory genes in rat lungs.

Marwick JA, Kirkham PA, Stevenson CS, Danahay H, Giddings J, Butler K, Donaldson K, Macnee W, Rahman I.

Am J Respir Cell Mol Biol. 2004 Dec;31(6):633-42. Epub 2004 Aug 27.


Differential protease, innate immunity, and NF-kappaB induction profiles during lung inflammation induced by subchronic cigarette smoke exposure in mice.

Vlahos R, Bozinovski S, Jones JE, Powell J, Gras J, Lilja A, Hansen MJ, Gualano RC, Irving L, Anderson GP.

Am J Physiol Lung Cell Mol Physiol. 2006 May;290(5):L931-45. Epub 2005 Dec 16.


Targeted disruption of NF-{kappa}B1 (p50) augments cigarette smoke-induced lung inflammation and emphysema in mice: a critical role of p50 in chromatin remodeling.

Rajendrasozhan S, Chung S, Sundar IK, Yao H, Rahman I.

Am J Physiol Lung Cell Mol Physiol. 2010 Feb;298(2):L197-209. doi: 10.1152/ajplung.00265.2009. Epub 2009 Dec 4.


SIRT1 longevity factor suppresses NF-kappaB -driven immune responses: regulation of aging via NF-kappaB acetylation?

Salminen A, Kauppinen A, Suuronen T, Kaarniranta K.

Bioessays. 2008 Oct;30(10):939-42. doi: 10.1002/bies.20799.


Exposure to cigarette smoke upregulates AP-1 activity and induces TNF-alpha overexpression in mouse lungs.

Li YT, He B, Wang YZ.

Inhal Toxicol. 2009 Jun;21(7):641-7. doi: 10.1080/08958370802322596.


Vasoprotective effects of resveratrol and SIRT1: attenuation of cigarette smoke-induced oxidative stress and proinflammatory phenotypic alterations.

Csiszar A, Labinskyy N, Podlutsky A, Kaminski PM, Wolin MS, Zhang C, Mukhopadhyay P, Pacher P, Hu F, de Cabo R, Ballabh P, Ungvari Z.

Am J Physiol Heart Circ Physiol. 2008 Jun;294(6):H2721-35. doi: 10.1152/ajpheart.00235.2008. Epub 2008 Apr 18.


Effect of erythromycin on cigarette-induced histone deacetylase protein expression and nuclear factor-κB activity in human macrophages in vitro.

Li M, Zhong X, He Z, Wen M, Li J, Peng X, Liu G, Deng J, Zhang J, Bai J.

Int Immunopharmacol. 2012 Apr;12(4):643-50. doi: 10.1016/j.intimp.2011.12.022. Epub 2012 Jan 20.


NF-kappaB mediates the survival of human bronchial epithelial cells exposed to cigarette smoke extract.

Liu X, Togo S, Al-Mugotir M, Kim H, Fang Q, Kobayashi T, Wang X, Mao L, Bitterman P, Rennard S.

Respir Res. 2008 Sep 23;9:66. doi: 10.1186/1465-9921-9-66.


Simvastatin inhibits induction of matrix metalloproteinase-9 in rat alveolar macrophages exposed to cigarette smoke extract.

Kim SE, Thanh Thuy TT, Lee JH, Ro JY, Bae YA, Kong Y, Ahn JY, Lee DS, Oh YM, Lee SD, Lee YS.

Exp Mol Med. 2009 Apr 30;41(4):277-87. doi: 10.3858/emm.2009.41.4.031.


SIRT1 activators suppress inflammatory responses through promotion of p65 deacetylation and inhibition of NF-κB activity.

Yang H, Zhang W, Pan H, Feldser HG, Lainez E, Miller C, Leung S, Zhong Z, Zhao H, Sweitzer S, Considine T, Riera T, Suri V, White B, Ellis JL, Vlasuk GP, Loh C.

PLoS One. 2012;7(9):e46364. doi: 10.1371/journal.pone.0046364. Epub 2012 Sep 28.


Baicalin attenuates inflammation by inhibiting NF-kappaB activation in cigarette smoke induced inflammatory models.

Lixuan Z, Jingcheng D, Wenqin Y, Jianhua H, Baojun L, Xiaotao F.

Pulm Pharmacol Ther. 2010 Oct;23(5):411-9. doi: 10.1016/j.pupt.2010.05.004. Epub 2010 May 23.


Cigarette smoke induces proinflammatory cytokine release by activation of NF-kappaB and posttranslational modifications of histone deacetylase in macrophages.

Yang SR, Chida AS, Bauter MR, Shafiq N, Seweryniak K, Maggirwar SB, Kilty I, Rahman I.

Am J Physiol Lung Cell Mol Physiol. 2006 Jul;291(1):L46-57. Epub 2006 Feb 10.


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