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The mechanism of flow-induced dilation in human adipose arterioles involves hydrogen peroxide during CAD.

Phillips SA, Hatoum OA, Gutterman DD.

Am J Physiol Heart Circ Physiol. 2007 Jan;292(1):H93-100. Epub 2006 Oct 13.


Ceramide changes the mediator of flow-induced vasodilation from nitric oxide to hydrogen peroxide in the human microcirculation.

Freed JK, Beyer AM, LoGiudice JA, Hockenberry JC, Gutterman DD.

Circ Res. 2014 Aug 15;115(5):525-32. doi: 10.1161/CIRCRESAHA.115.303881. Epub 2014 Jun 11.


Critical Role for Telomerase in the Mechanism of Flow-Mediated Dilation in the Human Microcirculation.

Beyer AM, Freed JK, Durand MJ, Riedel M, Ait-Aissa K, Green P, Hockenberry JC, Morgan RG, Donato AJ, Peleg R, Gasparri M, Rokkas CK, Santos JH, Priel E, Gutterman DD.

Circ Res. 2016 Mar 4;118(5):856-66. doi: 10.1161/CIRCRESAHA.115.307918. Epub 2015 Dec 23.


Nitric oxide and H2O2 contribute to reactive dilation of isolated coronary arterioles.

Koller A, Bagi Z.

Am J Physiol Heart Circ Physiol. 2004 Dec;287(6):H2461-7. Epub 2004 Aug 19.


Exercise training enhances flow-induced vasodilation in skeletal muscle resistance arteries of aged rats: role of PGI2 and nitric oxide.

Spier SA, Delp MD, Stallone JN, Dominguez JM 2nd, Muller-Delp JM.

Am J Physiol Heart Circ Physiol. 2007 Jun;292(6):H3119-27. Epub 2007 Mar 2.


Endothelial nitric oxide synthase activation leads to dilatory H2O2 production in mouse cerebral arteries.

Drouin A, Thorin-Trescases N, Hamel E, Falck JR, Thorin E.

Cardiovasc Res. 2007 Jan 1;73(1):73-81. Epub 2006 Oct 13.


Role for hydrogen peroxide in flow-induced dilation of human coronary arterioles.

Miura H, Bosnjak JJ, Ning G, Saito T, Miura M, Gutterman DD.

Circ Res. 2003 Feb 7;92(2):e31-40.


Flow-induced dilation of human coronary arterioles: important role of Ca(2+)-activated K(+) channels.

Miura H, Wachtel RE, Liu Y, Loberiza FR Jr, Saito T, Miura M, Gutterman DD.

Circulation. 2001 Apr 17;103(15):1992-8.


Upregulation of arginase by H2O2 impairs endothelium-dependent nitric oxide-mediated dilation of coronary arterioles.

Thengchaisri N, Hein TW, Wang W, Xu X, Li Z, Fossum TW, Kuo L.

Arterioscler Thromb Vasc Biol. 2006 Sep;26(9):2035-42. Epub 2006 Jun 22.


Role of Cu,Zn-SOD in the synthesis of endogenous vasodilator hydrogen peroxide during reactive hyperemia in mouse mesenteric microcirculation in vivo.

Yada T, Shimokawa H, Morikawa K, Takaki A, Shinozaki Y, Mori H, Goto M, Ogasawara Y, Kajiya F.

Am J Physiol Heart Circ Physiol. 2008 Jan;294(1):H441-8. Epub 2007 Nov 16.


Exercise training restores coronary arteriolar dilation to NOS activation distal to coronary artery occlusion: role of hydrogen peroxide.

Thengchaisri N, Shipley R, Ren Y, Parker J, Kuo L.

Arterioscler Thromb Vasc Biol. 2007 Apr;27(4):791-8. Epub 2007 Jan 18.


Vascular Actions of Angiotensin 1-7 in the Human Microcirculation: Novel Role for Telomerase.

Durand MJ, Zinkevich NS, Riedel M, Gutterman DD, Nasci VL, Salato VK, Hijjawi JB, Reuben CF, North PE, Beyer AM.

Arterioscler Thromb Vasc Biol. 2016 Jun;36(6):1254-62. doi: 10.1161/ATVBAHA.116.307518. Epub 2016 Apr 14.


Role of hydrogen peroxide in ACh-induced dilation of human submucosal intestinal microvessels.

Hatoum OA, Binion DG, Miura H, Telford G, Otterson MF, Gutterman DD.

Am J Physiol Heart Circ Physiol. 2005 Jan;288(1):H48-54. Epub 2004 Sep 2.


Microvascular dysfunction after transient high glucose is caused by superoxide-dependent reduction in the bioavailability of NO and BH(4).

Bagi Z, Toth E, Koller A, Kaley G.

Am J Physiol Heart Circ Physiol. 2004 Aug;287(2):H626-33. Epub 2004 Mar 25.


Effect of gender on endothelium-dependent dilation to bradykinin in human adipose microvessels.

Sato A, Miura H, Liu Y, Somberg LB, Otterson MF, Demeure MJ, Schulte WJ, Eberhardt LM, Loberiza FR, Sakuma I, Gutterman DD.

Am J Physiol Heart Circ Physiol. 2002 Sep;283(3):H845-52.


Simvastatin elicits dilation of isolated porcine retinal arterioles: role of nitric oxide and mevalonate-rho kinase pathways.

Nagaoka T, Hein TW, Yoshida A, Kuo L.

Invest Ophthalmol Vis Sci. 2007 Feb;48(2):825-32.


Contribution of KV1.5 Channel to Hydrogen Peroxide-Induced Human Arteriolar Dilation and Its Modulation by Coronary Artery Disease.

Nishijima Y, Cao S, Chabowski DS, Korishettar A, Ge A, Zheng X, Sparapani R, Gutterman DD, Zhang DX.

Circ Res. 2017 Feb 17;120(4):658-669. doi: 10.1161/CIRCRESAHA.116.309491. Epub 2016 Nov 21.


An acute rise in intraluminal pressure shifts the mediator of flow-mediated dilation from nitric oxide to hydrogen peroxide in human arterioles.

Beyer AM, Durand MJ, Hockenberry J, Gamblin TC, Phillips SA, Gutterman DD.

Am J Physiol Heart Circ Physiol. 2014 Dec 1;307(11):H1587-93. doi: 10.1152/ajpheart.00557.2014. Epub 2014 Sep 26.


Aging impairs flow-induced dilation in coronary arterioles: role of NO and H(2)O(2).

Kang LS, Reyes RA, Muller-Delp JM.

Am J Physiol Heart Circ Physiol. 2009 Sep;297(3):H1087-95. doi: 10.1152/ajpheart.00356.2009. Epub 2009 Jul 17.


Mechanism of thrombin-induced vasodilation in human coronary arterioles.

Bosnjak JJ, Terata K, Miura H, Sato A, Nicolosi AC, McDonald M, Manthei SA, Saito T, Hatoum OA, Gutterman DD.

Am J Physiol Heart Circ Physiol. 2003 Apr;284(4):H1080-6. Epub 2002 Dec 19.

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