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Items: 1 to 20 of 53

1.

Mechanisms of endothelial cell protection by blockade of the JAK2 pathway.

Neria F, Caramelo C, Peinado H, González-Pacheco FR, Deudero JJ, de Solis AJ, Fernández-Sánchez R, Peñate S, Cano A, Castilla MA.

Am J Physiol Cell Physiol. 2007 Mar;292(3):C1123-31. Epub 2006 Oct 11.

2.

Hydrogen peroxide stimulates tetrahydrobiopterin synthesis through activation of the Jak2 tyrosine kinase pathway in vascular endothelial cells.

Shimizu S, Hiroi T, Ishii M, Hagiwara T, Wajima T, Miyazaki A, Kiuchi Y.

Int J Biochem Cell Biol. 2008;40(4):755-65. Epub 2007 Oct 18.

PMID:
18054268
3.
4.

Homoharringtonine affects the JAK2-STAT5 signal pathway through alteration of protein tyrosine kinase phosphorylation in acute myeloid leukemia cells.

Tong H, Ren Y, Zhang F, Jin J.

Eur J Haematol. 2008 Oct;81(4):259-66. doi: 10.1111/j.1600-0609.2008.01116.x. Epub 2008 Jul 8.

PMID:
18616510
5.

β Common receptor integrates the erythropoietin signaling in activation of endothelial nitric oxide synthase.

Su KH, Shyue SK, Kou YR, Ching LC, Chiang AN, Yu YB, Chen CY, Pan CC, Lee TS.

J Cell Physiol. 2011 Dec;226(12):3330-9. doi: 10.1002/jcp.22678.

PMID:
21321940
6.
7.

Concomitant inactivation of the epidermal growth factor receptor, phosphatidylinositol 3-kinase/Akt and Janus tyrosine kinase 2/signal transducer and activator of transcription 3 signalling pathways in cardiotoxin III-treated A549 cells.

Su JC, Lin KL, Chien CM, Chuang PW, Chang LS, Lin SR.

Clin Exp Pharmacol Physiol. 2010 Aug;37(8):833-40. doi: 10.1111/j.1440-1681.2010.05397.x. Epub 2010 Apr 26.

PMID:
20456425
8.

Interleukin-6-induced JAK2/STAT3 signaling pathway in endothelial cells is suppressed by hemodynamic flow.

Ni CW, Hsieh HJ, Chao YJ, Wang DL.

Am J Physiol Cell Physiol. 2004 Sep;287(3):C771-80. Epub 2004 May 19.

9.

WP1066 disrupts Janus kinase-2 and induces caspase-dependent apoptosis in acute myelogenous leukemia cells.

Ferrajoli A, Faderl S, Van Q, Koch P, Harris D, Liu Z, Hazan-Halevy I, Wang Y, Kantarjian HM, Priebe W, Estrov Z.

Cancer Res. 2007 Dec 1;67(23):11291-9.

10.

Lactogens promote beta cell survival through JAK2/STAT5 activation and Bcl-XL upregulation.

Fujinaka Y, Takane K, Yamashita H, Vasavada RC.

J Biol Chem. 2007 Oct 19;282(42):30707-17. Epub 2007 Aug 29.

11.

Jak2 tyrosine kinase mediates oxidative stress-induced apoptosis in vascular smooth muscle cells.

Sandberg EM, Sayeski PP.

J Biol Chem. 2004 Aug 13;279(33):34547-52. Epub 2004 May 24.

12.

Constitutive activation of Jak2 contributes to proliferation and resistance to apoptosis in NPM/ALK-transformed cells.

Ruchatz H, Coluccia AM, Stano P, Marchesi E, Gambacorti-Passerini C.

Exp Hematol. 2003 Apr;31(4):309-15.

PMID:
12691918
13.
16.

IL-6 regulates MMP-10 expression via JAK2/STAT3 signaling pathway in a human lung adenocarcinoma cell line.

Zhang X, Yin P, DI D, Luo G, Zheng L, Wei J, Zhang J, Shi Y, Zhang J, Xu N.

Anticancer Res. 2009 Nov;29(11):4497-501.

17.

A novel small molecule deubiquitinase inhibitor blocks Jak2 signaling through Jak2 ubiquitination.

Kapuria V, Levitzki A, Bornmann WG, Maxwell D, Priebe W, Sorenson RJ, Showalter HD, Talpaz M, Donato NJ.

Cell Signal. 2011 Dec;23(12):2076-85. doi: 10.1016/j.cellsig.2011.08.002. Epub 2011 Aug 9.

PMID:
21855629
18.

Inhibition of Janus kinase 2 and signal transduction and activator of transcription 3 protect against cecal ligation and puncture-induced multiple organ damage and mortality.

Hui L, Yao Y, Wang S, Yu Y, Dong N, Li H, Sheng Z.

J Trauma. 2009 Mar;66(3):859-65. doi: 10.1097/TA.0b013e318164d05f.

PMID:
19276765
20.

Inhibition of JAK2 protects renal endothelial and epithelial cells from oxidative stress and cyclosporin A toxicity.

Neria F, Castilla MA, Sanchez RF, Gonzalez Pacheco FR, Deudero JJ, Calabia O, Tejedor A, Manzarbeitia F, Ortiz A, Caramelo C.

Kidney Int. 2009 Jan;75(2):227-34. doi: 10.1038/ki.2008.487. Epub 2008 Sep 24.

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