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Selection of stem cells by using antibodies that target different CD34 epitopes yields different patterns of T-cell differentiation.

Otto M, Chen X, Martin WJ, Leung W, Knowles J, Holladay M, Houston J, Handgretinger R, Barfield RC.

Stem Cells. 2007 Feb;25(2):537-42. Epub 2006 Oct 5.


Human thymus contains multipotent progenitors with T/B lymphoid, myeloid, and erythroid lineage potential.

Weerkamp F, Baert MR, Brugman MH, Dik WA, de Haas EF, Visser TP, de Groot CJ, Wagemaker G, van Dongen JJ, Staal FJ.

Blood. 2006 Apr 15;107(8):3131-7. Epub 2005 Dec 29.


Generation of T cells from adult human hematopoietic stem cells and progenitors in a fetal thymic organ culture system: stimulation by tumor necrosis factor-alpha.

Weekx SF, Snoeck HW, Offner F, De Smedt M, Van Bockstaele DR, Nijs G, Lenjou M, Moulijn A, Rodrigus I, Berneman ZN, Plum J.

Blood. 2000 May 1;95(9):2806-12.


Adapted NOD/SCID model supports development of phenotypically and functionally mature T cells from human umbilical cord blood CD34(+) cells.

Kerre TC, De Smet G, De Smedt M, Zippelius A, Pittet MJ, Langerak AW, De Bosscher J, Offner F, Vandekerckhove B, Plum J.

Blood. 2002 Mar 1;99(5):1620-6.


Human CD34+ cell preparations contain over 100-fold greater NOD/SCID mouse engrafting capacity than do CD34- cell preparations.

Gao Z, Fackler MJ, Leung W, Lumkul R, Ramirez M, Theobald N, Malech HL, Civin CI.

Exp Hematol. 2001 Jul;29(7):910-21.


Effects of CD34+ selection and T cell immunodepletion on cord blood hematopoietic progenitors: relevance to stem cell transplantation.

Laver J, Traycoff CM, Abdel-Mageed A, Gee A, Lee C, Turner C, Srour EF, Abboud M.

Exp Hematol. 1995 Dec;23(14):1492-6.


Tumor necrosis factor promotes human T-cell development in nonobese diabetic/severe combined immunodeficient mice.

Samira S, Ferrand C, Peled A, Nagler A, Tovbin Y, Ben-Hur H, Taylor N, Globerson A, Lapidot T.

Stem Cells. 2004;22(6):1085-100.


In vivo engraftment potential of clinical hematopoietic grafts.

Leung W, Ramírez M, Novelli EM, Civin CI.

J Investig Med. 1998 Aug;46(6):303-11.


Development of functional human blood and immune systems in NOD/SCID/IL2 receptor {gamma} chain(null) mice.

Ishikawa F, Yasukawa M, Lyons B, Yoshida S, Miyamoto T, Yoshimoto G, Watanabe T, Akashi K, Shultz LD, Harada M.

Blood. 2005 Sep 1;106(5):1565-73. Epub 2005 May 26.


Transplantation of X-linked severe combined immunodeficient dogs with CD34+ bone marrow cells.

Hartnett BJ, Yao D, Suter SE, Ellinwood NM, Henthorn PS, Moore PE, McSweeney PA, Nash RA, Brown JD, Weinberg KI, Felsburg PJ.

Biol Blood Marrow Transplant. 2002;8(4):188-97.


Allogeneic T cells induce rapid CD34+ cell differentiation into CD11c+CD86+ cells with direct and indirect antigen-presenting function.

Abbasian J, Mahmud D, Mahmud N, Chunduri S, Araki H, Reddy P, Hoffman R, Arpinati M, Ferrara JL, Rondelli D.

Blood. 2006 Jul 1;108(1):203-8. Epub 2006 Feb 14.


The role of the different CD34 epitopes in detection and positive selection of CD34+ bone marrow and peripheral blood stem cells.

Croockewit AJ, Raymakers RA, Preijers FW, Vierwinden G, de Witte TJ.

Scand J Immunol. 1998 Jan;47(1):82-90.


Improved T and B cell recovery by the transfer of slowly dividing human hematopoietic stem cells.

Vitacolonna M, Schubert M, Herbert N, Taubert I, Singh R, Ho A, Zöller M.

Leuk Res. 2010 May;34(5):622-30. doi: 10.1016/j.leukres.2009.10.015. Epub 2009 Nov 10.


Re: Selection of stem cells by using antibodies that target different CD34 epitopes yields different patterns of T-cell differentiation.

Sutherland DR, Keeney M.

Stem Cells. 2007 Sep;25(9):2385-6. Epub 2007 Jun 14. No abstract available.


A prospective comparison of immune reconstitution in pediatric recipients of positively selected CD34+ peripheral blood stem cells from unrelated donors vs recipients of unmanipulated bone marrow from related donors.

Eyrich M, Leiler C, Lang P, Schilbach K, Schumm M, Bader P, Greil J, Klingebiel T, Handgretinger R, Niethammer D, Schlegel PG.

Bone Marrow Transplant. 2003 Aug;32(4):379-90.


Interleukin-7 is a critical growth factor in early human T-cell development.

Plum J, De Smedt M, Leclercq G, Verhasselt B, Vandekerckhove B.

Blood. 1996 Dec 1;88(11):4239-45.


Long-term platelet production assessed in NOD/SCID mice injected with cord blood CD34+ cells, thrombopoietin-amplified in clinical grade serum-free culture.

Mattia G, Milazzo L, Vulcano F, Pascuccio M, Macioce G, Hassan HJ, Giampaolo A.

Exp Hematol. 2008 Feb;36(2):244-52. Epub 2007 Nov 26.


The analysis of the functions of human B and T cells in humanized NOD/shi-scid/gammac(null) (NOG) mice (hu-HSC NOG mice).

Watanabe Y, Takahashi T, Okajima A, Shiokawa M, Ishii N, Katano I, Ito R, Ito M, Minegishi M, Minegishi N, Tsuchiya S, Sugamura K.

Int Immunol. 2009 Jul;21(7):843-58. doi: 10.1093/intimm/dxp050. Epub 2009 Jun 10.


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