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Items: 1 to 20 of 126

1.

Kinesin-2 mediates physical and functional interactions between polycystin-2 and fibrocystin.

Wu Y, Dai XQ, Li Q, Chen CX, Mai W, Hussain Z, Long W, Montalbetti N, Li G, Glynne R, Wang S, Cantiello HF, Wu G, Chen XZ.

Hum Mol Genet. 2006 Nov 15;15(22):3280-92. Epub 2006 Sep 28.

PMID:
17008358
2.

Polycystin-2 expression is regulated by a PC2-binding domain in the intracellular portion of fibrocystin.

Kim I, Li C, Liang D, Chen XZ, Coffy RJ, Ma J, Zhao P, Wu G.

J Biol Chem. 2008 Nov 14;283(46):31559-66. doi: 10.1074/jbc.M805452200. Epub 2008 Sep 9.

3.

Fibrocystin/polyductin modulates renal tubular formation by regulating polycystin-2 expression and function.

Kim I, Fu Y, Hui K, Moeckel G, Mai W, Li C, Liang D, Zhao P, Ma J, Chen XZ, George AL Jr, Coffey RJ, Feng ZP, Wu G.

J Am Soc Nephrol. 2008 Mar;19(3):455-68. doi: 10.1681/ASN.2007070770. Epub 2008 Jan 30.

4.

Reduced ciliary polycystin-2 in induced pluripotent stem cells from polycystic kidney disease patients with PKD1 mutations.

Freedman BS, Lam AQ, Sundsbak JL, Iatrino R, Su X, Koon SJ, Wu M, Daheron L, Harris PC, Zhou J, Bonventre JV.

J Am Soc Nephrol. 2013 Oct;24(10):1571-86. doi: 10.1681/ASN.2012111089. Epub 2013 Sep 5.

5.

Fibrocystin/polyductin, found in the same protein complex with polycystin-2, regulates calcium responses in kidney epithelia.

Wang S, Zhang J, Nauli SM, Li X, Starremans PG, Luo Y, Roberts KA, Zhou J.

Mol Cell Biol. 2007 Apr;27(8):3241-52. Epub 2007 Feb 5.

6.

Alpha-actinin associates with polycystin-2 and regulates its channel activity.

Li Q, Montalbetti N, Shen PY, Dai XQ, Cheeseman CI, Karpinski E, Wu G, Cantiello HF, Chen XZ.

Hum Mol Genet. 2005 Jun 15;14(12):1587-603. Epub 2005 Apr 20.

PMID:
15843396
7.

Polycystin-2 cation channel function is under the control of microtubular structures in primary cilia of renal epithelial cells.

Li Q, Montalbetti N, Wu Y, Ramos A, Raychowdhury MK, Chen XZ, Cantiello HF.

J Biol Chem. 2006 Dec 8;281(49):37566-75. Epub 2006 Sep 1.

8.

Polycystin-2 cation channel function in the human syncytiotrophoblast is regulated by microtubular structures.

Montalbetti N, Li Q, Wu Y, Chen XZ, Cantiello HF.

J Physiol. 2007 Mar 15;579(Pt 3):717-28. Epub 2007 Jan 4.

9.

Polycystin-1 maturation requires polycystin-2 in a dose-dependent manner.

Gainullin VG, Hopp K, Ward CJ, Hommerding CJ, Harris PC.

J Clin Invest. 2015 Feb;125(2):607-20. doi: 10.1172/JCI76972. Epub 2015 Jan 9.

10.

A polycystin-2 (TRPP2) dimerization domain essential for the function of heteromeric polycystin complexes.

Giamarchi A, Feng S, Rodat-Despoix L, Xu Y, Bubenshchikova E, Newby LJ, Hao J, Gaudioso C, Crest M, Lupas AN, Honoré E, Williamson MP, Obara T, Ong AC, Delmas P.

EMBO J. 2010 Apr 7;29(7):1176-91. doi: 10.1038/emboj.2010.18. Epub 2010 Feb 18.

11.

Polycystin-1 negatively regulates Polycystin-2 expression via the aggresome/autophagosome pathway.

Cebotaru V, Cebotaru L, Kim H, Chiaravalli M, Boletta A, Qian F, Guggino WB.

J Biol Chem. 2014 Mar 7;289(10):6404-14. doi: 10.1074/jbc.M113.501205. Epub 2014 Jan 23.

12.

Polycystin 2 interacts with type I inositol 1,4,5-trisphosphate receptor to modulate intracellular Ca2+ signaling.

Li Y, Wright JM, Qian F, Germino GG, Guggino WB.

J Biol Chem. 2005 Dec 16;280(50):41298-306. Epub 2005 Oct 13.

13.

Direct binding of alpha-actinin enhances TRPP3 channel activity.

Li Q, Dai XQ, Shen PY, Wu Y, Long W, Chen CX, Hussain Z, Wang S, Chen XZ.

J Neurochem. 2007 Dec;103(6):2391-400. Epub 2007 Oct 17.

14.

Polycystin-2 associates with tropomyosin-1, an actin microfilament component.

Li Q, Dai Y, Guo L, Liu Y, Hao C, Wu G, Basora N, Michalak M, Chen XZ.

J Mol Biol. 2003 Jan 31;325(5):949-62.

PMID:
12527301
15.

Identification and functional characterization of an N-terminal oligomerization domain for polycystin-2.

Feng S, Okenka GM, Bai CX, Streets AJ, Newby LJ, DeChant BT, Tsiokas L, Obara T, Ong AC.

J Biol Chem. 2008 Oct 17;283(42):28471-9. doi: 10.1074/jbc.M803834200. Epub 2008 Aug 13.

16.

Polycystin-2 induces a conformational change in polycystin-1.

Oatley P, Talukder MM, Stewart AP, Sandford R, Edwardson JM.

Biochemistry. 2013 Aug 6;52(31):5280-7. doi: 10.1021/bi400233e. Epub 2013 Jul 24.

PMID:
23848298
17.

Molecular basis of autosomal recessive polycystic kidney disease (ARPKD).

Al-Bhalal L, Akhtar M.

Adv Anat Pathol. 2008 Jan;15(1):54-8. Review.

PMID:
18156813
18.

Regulation of Polycystin-1 Function by Calmodulin Binding.

Doerr N, Wang Y, Kipp KR, Liu G, Benza JJ, Pletnev V, Pavlov TS, Staruschenko A, Mohieldin AM, Takahashi M, Nauli SM, Weimbs T.

PLoS One. 2016 Aug 25;11(8):e0161525. doi: 10.1371/journal.pone.0161525. eCollection 2016.

19.

Hyperphosphorylation of polycystin-2 at a critical residue in disease reveals an essential role for polycystin-1-regulated dephosphorylation.

Streets AJ, Wessely O, Peters DJ, Ong AC.

Hum Mol Genet. 2013 May 15;22(10):1924-39. doi: 10.1093/hmg/ddt031. Epub 2013 Feb 5.

20.

Human ADPKD primary cyst epithelial cells with a novel, single codon deletion in the PKD1 gene exhibit defective ciliary polycystin localization and loss of flow-induced Ca2+ signaling.

Xu C, Rossetti S, Jiang L, Harris PC, Brown-Glaberman U, Wandinger-Ness A, Bacallao R, Alper SL.

Am J Physiol Renal Physiol. 2007 Mar;292(3):F930-45. Epub 2006 Nov 7.

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