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Items: 1 to 20 of 138


Cutting edge: ASC mediates the induction of multiple cytokines by Porphyromonas gingivalis via caspase-1-dependent and -independent pathways.

Taxman DJ, Zhang J, Champagne C, Bergstralh DT, Iocca HA, Lich JD, Ting JP.

J Immunol. 2006 Oct 1;177(7):4252-6.


Distinct roles of TLR2 and the adaptor ASC in IL-1beta/IL-18 secretion in response to Listeria monocytogenes.

Ozören N, Masumoto J, Franchi L, Kanneganti TD, Body-Malapel M, Ertürk I, Jagirdar R, Zhu L, Inohara N, Bertin J, Coyle A, Grant EP, Núñez G.

J Immunol. 2006 Apr 1;176(7):4337-42.


Effects of ketamine on levels of cytokines, NF-kappaB and TLRs in rat intestine during CLP-induced sepsis.

Yu M, Shao D, Liu J, Zhu J, Zhang Z, Xu J.

Int Immunopharmacol. 2007 Aug;7(8):1076-82. Epub 2007 May 2.


PYPAF3, a PYRIN-containing APAF-1-like protein, is a feedback regulator of caspase-1-dependent interleukin-1beta secretion.

Kinoshita T, Wang Y, Hasegawa M, Imamura R, Suda T.

J Biol Chem. 2005 Jun 10;280(23):21720-5. Epub 2005 Apr 6.


Toll-like receptor 4-dependent recognition of structurally different forms of chemically synthesized lipid As of Porphyromonas gingivalis.

Sawada N, Ogawa T, Asai Y, Makimura Y, Sugiyama A.

Clin Exp Immunol. 2007 Jun;148(3):529-36. Epub 2007 Mar 5.


ASC is essential for LPS-induced activation of procaspase-1 independently of TLR-associated signal adaptor molecules.

Yamamoto M, Yaginuma K, Tsutsui H, Sagara J, Guan X, Seki E, Yasuda K, Yamamoto M, Akira S, Nakanishi K, Noda T, Taniguchi S.

Genes Cells. 2004 Nov;9(11):1055-67.


Intracellular signaling and cytokine induction upon interactions of Porphyromonas gingivalis fimbriae with pattern-recognition receptors.

Hajishengallis G, Sojar H, Genco RJ, DeNardin E.

Immunol Invest. 2004 May;33(2):157-72.


Critical role of apoptotic speck protein containing a caspase recruitment domain (ASC) and NLRP3 in causing necrosis and ASC speck formation induced by Porphyromonas gingivalis in human cells.

Huang MT, Taxman DJ, Holley-Guthrie EA, Moore CB, Willingham SB, Madden V, Parsons RK, Featherstone GL, Arnold RR, O'Connor BP, Ting JP.

J Immunol. 2009 Feb 15;182(4):2395-404. doi: 10.4049/jimmunol.0800909.


ASC-mediated NF-kappaB activation leading to interleukin-8 production requires caspase-8 and is inhibited by CLARP.

Hasegawa M, Imamura R, Kinoshita T, Matsumoto N, Masumoto J, Inohara N, Suda T.

J Biol Chem. 2005 Apr 15;280(15):15122-30. Epub 2005 Feb 8.


Human gingival epithelial cells produce chemotactic factors interleukin-8 and monocyte chemoattractant protein-1 after stimulation with Porphyromonas gingivalis via toll-like receptor 2.

Kusumoto Y, Hirano H, Saitoh K, Yamada S, Takedachi M, Nozaki T, Ozawa Y, Nakahira Y, Saho T, Ogo H, Shimabukuro Y, Okada H, Murakami S.

J Periodontol. 2004 Mar;75(3):370-9.


Differential cytokine induction by two types of Porphyromonas gingivalis.

Sugano N, Ikeda K, Oshikawa M, Sawamoto Y, Tanaka H, Ito K.

Oral Microbiol Immunol. 2004 Apr;19(2):121-3.


Interleukin (IL)-23 p19 expression induced by IL-1beta in human fibroblast-like synoviocytes with rheumatoid arthritis via active nuclear factor-kappaB and AP-1 dependent pathway.

Liu FL, Chen CH, Chu SJ, Chen JH, Lai JH, Sytwu HK, Chang DM.

Rheumatology (Oxford). 2007 Aug;46(8):1266-73. Epub 2007 Jun 14.


In vivo induction of proinflammatory cytokines in mouse tissue by Porphyromonas gingivalis and Actinobacillus actinomycetemcomitans.

Kesavalu L, Chandrasekar B, Ebersole JL.

Oral Microbiol Immunol. 2002 Jun;17(3):177-80.


PAN1/NALP2/PYPAF2, an inducible inflammatory mediator that regulates NF-kappaB and caspase-1 activation in macrophages.

Bruey JM, Bruey-Sedano N, Newman R, Chandler S, Stehlik C, Reed JC.

J Biol Chem. 2004 Dec 10;279(50):51897-907. Epub 2004 Sep 28.


Fimbria-dependent activation of pro-inflammatory molecules in Porphyromonas gingivalis infected human aortic endothelial cells.

Takahashi Y, Davey M, Yumoto H, Gibson FC 3rd, Genco CA.

Cell Microbiol. 2006 May;8(5):738-57.


Anti-inflammatory activity of PYNOD and its mechanism in humans and mice.

Imamura R, Wang Y, Kinoshita T, Suzuki M, Noda T, Sagara J, Taniguchi S, Okamoto H, Suda T.

J Immunol. 2010 May 15;184(10):5874-84. doi: 10.4049/jimmunol.0900779. Epub 2010 Apr 14.


Mechanism and repertoire of ASC-mediated gene expression.

Hasegawa M, Imamura R, Motani K, Nishiuchi T, Matsumoto N, Kinoshita T, Suda T.

J Immunol. 2009 Jun 15;182(12):7655-62. doi: 10.4049/jimmunol.0800448.


Progesterone administration modulates TLRs/NF-kappaB signaling pathway in rat brain after cortical contusion.

Chen G, Shi J, Jin W, Wang L, Xie W, Sun J, Hang C.

Ann Clin Lab Sci. 2008 Winter;38(1):65-74.


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