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16963225,17449104,17499747,16126722,16219683,16380386,16061940,20599517,15911980,21900155,18619555,17560117,15625319,18058948,18951299,15258913,16936207,15710421,20568228,17913601,14708343,20518072,17440226,20679347,18425450,14742298,15802137,15217782,18216770,10419457,15715670,9007051,17168766,17259076,20193711,17211142,20207939,16940153,17010150,23994042,12783875,18751924,17280869,18172856,11694603,22613819,15743396,11814056,16555682,11087909,18953023,30154232,19734127,17283058,12637747,30389354,17242494,18481029,17158340,17475390,9160843,20709153,18694820,28551069,8660316,19240180,15585321,18680146,16996023,11915342,19101626,18321471,29766830,20696404,17626797,16873929,23035115,30612333,26190575,18058224,14760419,18547682,19027789,21341516,15900018,29269995,9126370,21062159,21437908,20456020,15184394,16916783,15796189,14528916,24269742,19070545,16530698,32392908,36142801,24708996,27771292,25424644,23563670,25233422,12617823,19721401,36549592,17325039,32894509,28540559,14504448,30287225,25613909,17346996,25781682,25964209,36229882,14998372,23921254,15750791,16099387,26244839,17308123,20919655,11752637,14628466,31817238,31243119,17553461,12485605,10912620,10567432,33376112,25319495,21148295,19513367,16988788,10231598,17252619,22113622,32430006,15946697,27565080,32579188,36671552,31462128,8379459,30569280,18165233,15737611,22528448,33232973,23563652,24101372,31801289,18191382,12531549,24713544,29229990,26667073,32977496,11583166,21888508,26172331,26521206,11308026,27335046,8903509,26703189,29662189,19563535,31363040,18755926,15356125,19749786,35897658,15966405,20559316,9874672,10973793,21075134,30951736,27826095,26474409,14602806,7559485,21864225,15052326,29147025,22633490,30523638,15498114,24088546,16730802,15666085,18691012,9799530,22940715,24977485,16847102,15942662,34560541,28369933,33432663,11829492,29242408,17035732,10424278,25867999,12417141,11915339,25434743,16034716,23366417,27169276,17979800,25386673,15571774,29401619,15137923,22804622,20215115,34064516,36012521,28361484,16183236,11162743,12790117,19519377,27317800,21615386,16584625,7759519,29788359,11278489,15271294,33991614,11591392,36122218,17713573,10101288,8761490,21569466,24899305,8663293,31390266,12037985,35568252,21335555,21537471,8245978,10652340,23318139,21613224,35134389,33785361,36142188,17884005,11001564,17980708,8203897,17202150,9822324,17954251,16098730,26553872,26747710,11884231,34638955,16913663,11324700,27562337,21535416,10101287,35270028,21127389,6814427,7429425,22989909,21707487,21597176,24339790,16167178,9538201,32356173,15741222,21181285,10080537,15258912,10423159,11168352,24977487,11396001,10900202,23175343,12807026,12676515,15845354,16803890,35887154,24394822,17070498,25941085,27609772,9030602,17204455,34998898,12123710,28660590,9070908,30478737,32028642,18294974,28271029,33771984,7061463,26573460,24970218,32498325,12093880,31002723,12531544,23563653,18184565,36674974,26286360,20085856,33355876,35743121,11324704,23969158,10563333,29908120,24990520,24092763,11875973,36361536,22454477,19066402,12499379,23467817,24056950,12650926,26609196,31916624,25525752,17243635,23563655,36233252,22322590,32668665,29376826,17706961,16903825,15112572,21368890,22246226,26884614,11709081,11001570,9692614,30108193,32291319,10563330,33863882,10213177,17393491,36430423,36757794,36534277,21800680,18978071,32959379,25997737,26220616,35104807,10583213,15801912,21733186,29143233,25748248,15953549,30890654,10679576,35187707,22999245,23563665,10419081,21707485,30632976,24977479,28745666,34289244,30377075,2499578,20502004,25903957,16046448,21566746,8365472,4554458,25581755,35354041,11586067,26639035,29590184,29207545,15661867,26792856,1495423,2384145,16815033,31906427,8169662,11356846,12485859,25395373,20587518,20425071,17881234,14741383,24302584,15954330,9431007,17331485,15286740,17164222,10396983,11792733,25859016,36048828,32770508,32072647,24939530,11592731,31632969,35004331,30720434,21707488,24866405,32402091,18298366,21910082,8568838,7922349,9192741,27909176,28785021,23423838,16568241,26150824,11330410,19348755,23980469,10424298,20112046,35020354,28243820,20170745,34026750,11284453,27234412,32722626,23609351,12676517,7451473,35409368,25309325,6444773,34668624,2208286,15548542,36768427,33723022,20919649,10563315,26715852,2187537,23717873,30926626,9645089,31427962,8379451,11877771,28012590,21303545,36557209,35886939,9668342,33496698,24064302,12166822,18061920,24977492,21490799,29610685,11915353,18363212,16611156,1487992,34912800,10397004,1808062,8368147,12648243,10563326,26394802,19050750,3729963,10563325,17981711,29680326,1466749,19928534,12676510,4585089,10446843,8741291,26242691,26580500,19190671,36305347,36305346,6724437,1198552,35069458,31844815,18909120,17754197[uid]

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Ceramide/sphingosine/sphingosine 1-phosphate metabolism on the cell surface and in the extracellular space.

Tani M, Ito M, Igarashi Y. Tani M, et al. Cell Signal. 2007 Feb;19(2):229-37. doi: 10.1016/j.cellsig.2006.07.001. Epub 2006 Sep 11. Cell Signal. 2007. PMID: 16963225 Review.

Metabolism and biological functions of two phosphorylated sphingolipids, sphingosine 1-phosphate and ceramide 1-phosphate.

Kihara A, Mitsutake S, Mizutani Y, Igarashi Y. Kihara A, et al. Prog Lipid Res. 2007 Mar;46(2):126-44. doi: 10.1016/j.plipres.2007.03.001. Epub 2007 Mar 14. Prog Lipid Res. 2007. PMID: 17449104 Review.

Partial hepatectomy activates production of the pro-mitotic intermediates of the sphingomyelin signal transduction pathway in the rat liver.

Zabielski P, Baranowski M, Zendzian-Piotrowska M, Blachnio A, Gorski J. Zabielski P, et al. Prostaglandins Other Lipid Mediat. 2007 Jun;83(4):277-84. doi: 10.1016/j.prostaglandins.2007.02.001. Epub 2007 Feb 11. Prostaglandins Other Lipid Mediat. 2007. PMID: 17499747

Involvement of neutral ceramidase in ceramide metabolism at the plasma membrane and in extracellular milieu.

Tani M, Igarashi Y, Ito M. Tani M, et al. J Biol Chem. 2005 Nov 4;280(44):36592-600. doi: 10.1074/jbc.M506827200. Epub 2005 Aug 25. J Biol Chem. 2005. PMID: 16126722 Free article.

Sphingosine 1-phosphate and ceramide 1-phosphate: expanding roles in cell signaling.

Chalfant CE, Spiegel S. Chalfant CE, et al. J Cell Sci. 2005 Oct 15;118(Pt 20):4605-12. doi: 10.1242/jcs.02637. J Cell Sci. 2005. PMID: 16219683 Review.

Neutral ceramidase encoded by the Asah2 gene is essential for the intestinal degradation of sphingolipids.

Kono M, Dreier JL, Ellis JM, Allende ML, Kalkofen DN, Sanders KM, Bielawski J, Bielawska A, Hannun YA, Proia RL. Kono M, et al. J Biol Chem. 2006 Mar 17;281(11):7324-31. doi: 10.1074/jbc.M508382200. Epub 2005 Dec 27. J Biol Chem. 2006. PMID: 16380386 Free article.

Mechanisms of sphingosine and sphingosine 1-phosphate generation in human platelets.

Tani M, Sano T, Ito M, Igarashi Y. Tani M, et al. J Lipid Res. 2005 Nov;46(11):2458-67. doi: 10.1194/jlr.M500268-JLR200. Epub 2005 Aug 1. J Lipid Res. 2005. PMID: 16061940 Free article.

The effect of high-fat diet on the sphingolipid pathway of signal transduction in regenerating rat liver.

Zabielski P, Baranowski M, Błachnio-Zabielska A, Zendzian-Piotrowska M, Górski J. Zabielski P, et al. Prostaglandins Other Lipid Mediat. 2010 Nov;93(3-4):75-83. doi: 10.1016/j.prostaglandins.2010.06.006. Epub 2010 Jul 3. Prostaglandins Other Lipid Mediat. 2010. PMID: 20599517

Measurement of ceramide and sphingolipid metabolism in tumors: potential modulation of chemotherapy.

Modrak DE. Modrak DE. Methods Mol Med. 2005;111:183-94. doi: 10.1385/1-59259-889-7:183. Methods Mol Med. 2005. PMID: 15911980

The role of sphingolipids in respiratory disease.

Yang Y, Uhlig S. Yang Y, et al. Ther Adv Respir Dis. 2011 Oct;5(5):325-44. doi: 10.1177/1753465811406772. Ther Adv Respir Dis. 2011. PMID: 21900155 Free article. Review.

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