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Human cytomegalovirus infection alters the substrate specificities and rapamycin sensitivities of raptor- and rictor-containing complexes.

Kudchodkar SB, Yu Y, Maguire TG, Alwine JC.

Proc Natl Acad Sci U S A. 2006 Sep 19;103(38):14182-7. Epub 2006 Sep 7.


SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity.

Jacinto E, Facchinetti V, Liu D, Soto N, Wei S, Jung SY, Huang Q, Qin J, Su B.

Cell. 2006 Oct 6;127(1):125-37. Epub 2006 Sep 7.


The changing role of mTOR kinase in the maintenance of protein synthesis during human cytomegalovirus infection.

Clippinger AJ, Maguire TG, Alwine JC.

J Virol. 2011 Apr;85(8):3930-9. doi: 10.1128/JVI.01913-10. Epub 2011 Feb 9.


Inhibition of mammalian target of rapamycin induces phosphatidylinositol 3-kinase-dependent and Mnk-mediated eukaryotic translation initiation factor 4E phosphorylation.

Wang X, Yue P, Chan CB, Ye K, Ueda T, Watanabe-Fukunaga R, Fukunaga R, Fu H, Khuri FR, Sun SY.

Mol Cell Biol. 2007 Nov;27(21):7405-13. Epub 2007 Aug 27.


PRR5, a novel component of mTOR complex 2, regulates platelet-derived growth factor receptor beta expression and signaling.

Woo SY, Kim DH, Jun CB, Kim YM, Haar EV, Lee SI, Hegg JW, Bandhakavi S, Griffin TJ, Kim DH.

J Biol Chem. 2007 Aug 31;282(35):25604-12. Epub 2007 Jun 28.


Increased AKT S473 phosphorylation after mTORC1 inhibition is rictor dependent and does not predict tumor cell response to PI3K/mTOR inhibition.

Breuleux M, Klopfenstein M, Stephan C, Doughty CA, Barys L, Maira SM, Kwiatkowski D, Lane HA.

Mol Cancer Ther. 2009 Apr;8(4):742-53. doi: 10.1158/1535-7163.MCT-08-0668.


mTORC1 and mTORC2 regulate insulin secretion through Akt in INS-1 cells.

Le Bacquer O, Queniat G, Gmyr V, Kerr-Conte J, Lefebvre B, Pattou F.

J Endocrinol. 2013 Jan 2;216(1):21-9. doi: 10.1530/JOE-12-0351. Print 2013 Jan.


Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton.

Sarbassov DD, Ali SM, Kim DH, Guertin DA, Latek RR, Erdjument-Bromage H, Tempst P, Sabatini DM.

Curr Biol. 2004 Jul 27;14(14):1296-302.


Enhancing mammalian target of rapamycin (mTOR)-targeted cancer therapy by preventing mTOR/raptor inhibition-initiated, mTOR/rictor-independent Akt activation.

Wang X, Yue P, Kim YA, Fu H, Khuri FR, Sun SY.

Cancer Res. 2008 Sep 15;68(18):7409-18. doi: 10.1158/0008-5472.CAN-08-1522.


Identification of rictor as a novel substrate of Polo-like kinase 1.

Shao T, Liu X.

Cell Cycle. 2015;14(5):755-60. doi: 10.1080/15384101.2014.998050.


Rapamycin attenuates BAFF-extended proliferation and survival via disruption of mTORC1/2 signaling in normal and neoplastic B-lymphoid cells.

Zeng Q, Qin S, Zhang H, Liu B, Qin J, Wang X, Zhang R, Liu C, Dong X, Zhang S, Huang S, Chen L.

J Cell Physiol. 2018 Jan;233(1):516-529. doi: 10.1002/jcp.25913. Epub 2017 May 3.


Regulation of endothelial cell proliferation and vascular assembly through distinct mTORC2 signaling pathways.

Wang S, Amato KR, Song W, Youngblood V, Lee K, Boothby M, Brantley-Sieders DM, Chen J.

Mol Cell Biol. 2015 Apr;35(7):1299-313. doi: 10.1128/MCB.00306-14. Epub 2015 Jan 12.


The mechanism of insulin-stimulated 4E-BP protein binding to mammalian target of rapamycin (mTOR) complex 1 and its contribution to mTOR complex 1 signaling.

Rapley J, Oshiro N, Ortiz-Vega S, Avruch J.

J Biol Chem. 2011 Nov 4;286(44):38043-53. doi: 10.1074/jbc.M111.245449. Epub 2011 Sep 13.


Rapamycin inhibits cytoskeleton reorganization and cell motility by suppressing RhoA expression and activity.

Liu L, Luo Y, Chen L, Shen T, Xu B, Chen W, Zhou H, Han X, Huang S.

J Biol Chem. 2010 Dec 3;285(49):38362-73. doi: 10.1074/jbc.M110.141168. Epub 2010 Oct 11.


Raptor-rictor axis in TGFbeta-induced protein synthesis.

Das F, Ghosh-Choudhury N, Mahimainathan L, Venkatesan B, Feliers D, Riley DJ, Kasinath BS, Choudhury GG.

Cell Signal. 2008 Feb;20(2):409-23. Epub 2007 Nov 7.


Rapamycin regulates the phosphorylation of rictor.

Akcakanat A, Singh G, Hung MC, Meric-Bernstam F.

Biochem Biophys Res Commun. 2007 Oct 19;362(2):330-3. Epub 2007 Aug 8.


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