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Items: 1 to 20 of 103

1.

Knockdown of amyloid precursor protein normalizes cholinergic function in a cell line derived from the cerebral cortex of a trisomy 16 mouse: An animal model of down syndrome.

Opazo P, Saud K, de Saint Pierre M, Cárdenas AM, Allen DD, Segura-Aguilar J, Caviedes R, Caviedes P.

J Neurosci Res. 2006 Nov 1;84(6):1303-10.

PMID:
16941497
2.

Impaired cholinergic function in cell lines derived from the cerebral cortex of normal and trisomy 16 mice.

Allen DD, Martín J, Arriagada C, Cárdenas AM, Rapoport SI, Caviedes R, Caviedes P.

Eur J Neurosci. 2000 Sep;12(9):3259-64.

PMID:
10998109
3.

Effect of the knockdown of amyloid precursor protein on intracellular calcium increases in a neuronal cell line derived from the cerebral cortex of a trisomy 16 mouse.

Rojas G, Cárdenas AM, Fernández-Olivares P, Shimahara T, Segura-Aguilar J, Caviedes R, Caviedes P.

Exp Neurol. 2008 Jan;209(1):234-42. Epub 2007 Oct 5.

PMID:
17976585
4.

Endosomal abnormalities related to amyloid precursor protein in cholesterol treated cerebral cortex neuronal cells derived from trisomy 16 mice, an animal model of Down syndrome.

Arriagada C, Astorga C, Atwater I, Rojas E, Mears D, Caviedes R, Caviedes P.

Neurosci Lett. 2007 Aug 16;423(2):172-7. Epub 2007 Aug 3.

PMID:
17706358
5.

Knockdown of Myo-Inositol Transporter SMIT1 Normalizes Cholinergic and Glutamatergic Function in an Immortalized Cell Line Established from the Cerebral Cortex of a Trisomy 16 Fetal Mouse, an Animal Model of Human Trisomy 21 (Down Syndrome).

Cárdenas AM, Fernández-Olivares P, Díaz-Franulic I, González-Jamett AM, Shimahara T, Segura-Aguilar J, Caviedes R, Caviedes P.

Neurotox Res. 2017 Jul 10. doi: 10.1007/s12640-017-9775-0. [Epub ahead of print]

PMID:
28695546
6.

Overexpression of DYRK1A inhibits choline acetyltransferase induction by oleic acid in cellular models of Down syndrome.

Hijazi M, Fillat C, Medina JM, Velasco A.

Exp Neurol. 2013 Jan;239:229-34. doi: 10.1016/j.expneurol.2012.10.016. Epub 2012 Nov 1.

PMID:
23124096
7.

Establishment and characterization of immortalized neuronal cell lines derived from the spinal cord of normal and trisomy 16 fetal mice, an animal model of Down syndrome.

Cárdenas AM, Allen DD, Arriagada C, Olivares A, Bennett LB, Caviedes R, Dagnino-Subiabre A, Mendoza IE, Segura-Aguilar J, Rapoport SI, Caviedes P.

J Neurosci Res. 2002 Apr 1;68(1):46-58.

PMID:
11933048
8.

Altered voltage dependent calcium currents in a neuronal cell line derived from the cerebral cortex of a trisomy 16 fetal mouse, an animal model of Down syndrome.

Acuña MA, Pérez-Nuñez R, Noriega J, Cárdenas AM, Bacigalupo J, Delgado R, Arriagada C, Segura-Aguilar J, Caviedes R, Caviedes P.

Neurotox Res. 2012 Jul;22(1):59-68. doi: 10.1007/s12640-011-9304-5. Epub 2011 Dec 28.

PMID:
22203612
9.

Regional alteration of cholinergic function in central neurons of trisomy 16 mouse fetuses, an animal model of human trisomy 21 (Down syndrome).

Fiedler JL, Epstein CJ, Rapoport SI, Caviedes R, Caviedes P.

Brain Res. 1994 Sep 26;658(1-2):27-32.

PMID:
7834352
10.

Small-molecule aggregation inhibitors reduce excess amyloid in a trisomy 16 mouse cortical cell line.

Paula Lima AC, Arriagada C, Toro R, Cárdenas AM, Caviedes R, Ferreira ST, Caviedes P.

Biol Res. 2008;41(2):129-36. doi: /S0716-97602008000200001. Epub 2008 Oct 8.

11.

App gene dosage modulates endosomal abnormalities of Alzheimer's disease in a segmental trisomy 16 mouse model of down syndrome.

Cataldo AM, Petanceska S, Peterhoff CM, Terio NB, Epstein CJ, Villar A, Carlson EJ, Staufenbiel M, Nixon RA.

J Neurosci. 2003 Jul 30;23(17):6788-92.

12.

The amyloid precursor protein (APP) triplicated gene impairs neuronal precursor differentiation and neurite development through two different domains in the Ts65Dn mouse model for Down syndrome.

Trazzi S, Fuchs C, Valli E, Perini G, Bartesaghi R, Ciani E.

J Biol Chem. 2013 Jul 19;288(29):20817-29. doi: 10.1074/jbc.M113.451088. Epub 2013 Jun 5.

13.

Age-dependent dysregulation of brain amyloid precursor protein in the Ts65Dn Down syndrome mouse model.

Choi JH, Berger JD, Mazzella MJ, Morales-Corraliza J, Cataldo AM, Nixon RA, Ginsberg SD, Levy E, Mathews PM.

J Neurochem. 2009 Sep;110(6):1818-27. doi: 10.1111/j.1471-4159.2009.06277.x. Epub 2009 Jul 10.

14.

Calcium signals in cell lines derived from the cerebral cortex of normal and trisomy 16 mice.

Cárdenas AM, Rodríguez MP, Cortés MP, Alvarez RM, Wei W, Rapoport SI, Shimahara T, Caviedes R, Caviedes P.

Neuroreport. 1999 Feb 5;10(2):363-9.

PMID:
10203336
15.

Cerebral cortical astroglia from the trisomy 16 mouse, a model for down syndrome, produce neuronal cholinergic deficits in cell culture.

Nelson PG, Fitzgerald S, Rapoport SI, Neale EA, Galdzicki Z, Dunlap V, Bowers L, v Agoston D.

Proc Natl Acad Sci U S A. 1997 Nov 11;94(23):12644-8.

16.

Cell lines derived from hippocampal neurons of the normal and trisomy 16 mouse fetus (a model for Down syndrome) exhibit neuronal markers, cholinergic function, and functional neurotransmitter receptors.

Cárdenas AM, Arriagada C, Allen DD, Caviedes R, Cortes JF, Martin J, Couve E, Rapoport SI, Shimahara T, Caviedes P.

Exp Neurol. 2002 Sep;177(1):159-70.

PMID:
12429219
17.

Overexpressed Down Syndrome Cell Adhesion Molecule (DSCAM) Deregulates P21-Activated Kinase (PAK) Activity in an In Vitro Neuronal Model of Down Syndrome: Consequences on Cell Process Formation and Extension.

Pérez-Núñez R, Barraza N, Gonzalez-Jamett A, Cárdenas AM, Barnier JV, Caviedes P.

Neurotox Res. 2016 Jul;30(1):76-87. doi: 10.1007/s12640-016-9613-9. Epub 2016 Mar 10.

PMID:
26966010
18.

Apoptosis is directly related to intracellular amyloid accumulation in a cell line derived from the cerebral cortex of a trisomy 16 mouse, an animal model of Down syndrome.

Arriagada C, Bustamante M, Atwater I, Rojas E, Caviedes R, Caviedes P.

Neurosci Lett. 2010 Feb 5;470(1):81-5. doi: 10.1016/j.neulet.2009.12.062. Epub 2009 Dec 30.

PMID:
20043975
19.

Survival and plasticity of basal forebrain cholinergic systems in mice transgenic for presenilin-1 and amyloid precursor protein mutant genes.

Hernandez D, Sugaya K, Qu T, McGowan E, Duff K, McKinney M.

Neuroreport. 2001 May 25;12(7):1377-84.

PMID:
11388415
20.

Abnormal APP, cholinergic and cognitive function in Ts65Dn Down's model mice.

Seo H, Isacson O.

Exp Neurol. 2005 Jun;193(2):469-80.

PMID:
15869949

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