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Hepatic knockdown of mitochondrial GPAT1 in ob/ob mice improves metabolic profile.

Xu H, Wilcox D, Nguyen P, Voorbach M, Suhar T, Morgan SJ, An WF, Ge L, Green J, Wu Z, Gimeno RE, Reilly R, Jacobson PB, Collins CA, Landschulz K, Surowy T.

Biochem Biophys Res Commun. 2006 Oct 13;349(1):439-48. Epub 2006 Aug 22.


The role of mitochondrial glycerol-3-phosphate acyltransferase-1 in regulating lipid and glucose homeostasis in high-fat diet fed mice.

Yazdi M, Ahnmark A, William-Olsson L, Snaith M, Turner N, Osla F, Wedin M, Asztély AK, Elmgren A, Bohlooly-Y M, Schreyer S, Lindén D.

Biochem Biophys Res Commun. 2008 May 16;369(4):1065-70. doi: 10.1016/j.bbrc.2008.02.156. Epub 2008 Mar 11.


Mitochondrial glycerol-3-phosphate acyltransferase-1 directs the metabolic fate of exogenous fatty acids in hepatocytes.

Lewin TM, Wang S, Nagle CA, Van Horn CG, Coleman RA.

Am J Physiol Endocrinol Metab. 2005 May;288(5):E835-44. Epub 2004 Dec 14.


Antisense oligonucleotide reduction of DGAT2 expression improves hepatic steatosis and hyperlipidemia in obese mice.

Yu XX, Murray SF, Pandey SK, Booten SL, Bao D, Song XZ, Kelly S, Chen S, McKay R, Monia BP, Bhanot S.

Hepatology. 2005 Aug;42(2):362-71.


Anthocyanin inhibits high glucose-induced hepatic mtGPAT1 activation and prevents fatty acid synthesis through PKCζ.

Guo H, Li D, Ling W, Feng X, Xia M.

J Lipid Res. 2011 May;52(5):908-22. doi: 10.1194/jlr.M013375. Epub 2011 Feb 22.


Hepatic knockdown of stearoyl-CoA desaturase 1 via RNA interference in obese mice decreases lipid content and changes fatty acid composition.

Xu H, Wilcox D, Nguyen P, Voorbach M, Smith H, Brodjian S, Suhar T, Reilly RM, Jacobson PB, Collins CA, Landschulz K, Surowy TK.

Front Biosci. 2007 May 1;12:3781-94.


Mitochondrial glycerol-3-phosphate acyltransferase-1 is essential in liver for the metabolism of excess acyl-CoAs.

Hammond LE, Neschen S, Romanelli AJ, Cline GW, Ilkayeva OR, Shulman GI, Muoio DM, Coleman RA.

J Biol Chem. 2005 Jul 8;280(27):25629-36. Epub 2005 May 6.


Overexpression of mitochondrial GPAT in rat hepatocytes leads to decreased fatty acid oxidation and increased glycerolipid biosynthesis.

Lindén D, William-Olsson L, Rhedin M, Asztély AK, Clapham JC, Schreyer S.

J Lipid Res. 2004 Jul;45(7):1279-88. Epub 2004 Apr 21.


Liver-directed overexpression of mitochondrial glycerol-3-phosphate acyltransferase results in hepatic steatosis, increased triacylglycerol secretion and reduced fatty acid oxidation.

Lindén D, William-Olsson L, Ahnmark A, Ekroos K, Hallberg C, Sjögren HP, Becker B, Svensson L, Clapham JC, Oscarsson J, Schreyer S.

FASEB J. 2006 Mar;20(3):434-43.


Deficiency of carbohydrate-activated transcription factor ChREBP prevents obesity and improves plasma glucose control in leptin-deficient (ob/ob) mice.

Iizuka K, Miller B, Uyeda K.

Am J Physiol Endocrinol Metab. 2006 Aug;291(2):E358-64. Epub 2006 May 16.


Glycerol-3-phosphate acyltransferase 1 deficiency in ob/ob mice diminishes hepatic steatosis but does not protect against insulin resistance or obesity.

Wendel AA, Li LO, Li Y, Cline GW, Shulman GI, Coleman RA.

Diabetes. 2010 Jun;59(6):1321-9. doi: 10.2337/db09-1380. Epub 2010 Mar 3.


Identification of a new glycerol-3-phosphate acyltransferase isoenzyme, mtGPAT2, in mitochondria.

Lewin TM, Schwerbrock NM, Lee DP, Coleman RA.

J Biol Chem. 2004 Apr 2;279(14):13488-95. Epub 2004 Jan 14.


Partial leptin deficiency favors diet-induced obesity and related metabolic disorders in mice.

Begriche K, Lettéron P, Abbey-Toby A, Vadrot N, Robin MA, Bado A, Pessayre D, Fromenty B.

Am J Physiol Endocrinol Metab. 2008 May;294(5):E939-51. doi: 10.1152/ajpendo.00379.2007. Epub 2008 Mar 18.


Prevention of hepatic steatosis and hepatic insulin resistance in mitochondrial acyl-CoA:glycerol-sn-3-phosphate acyltransferase 1 knockout mice.

Neschen S, Morino K, Hammond LE, Zhang D, Liu ZX, Romanelli AJ, Cline GW, Pongratz RL, Zhang XM, Choi CS, Coleman RA, Shulman GI.

Cell Metab. 2005 Jul;2(1):55-65.


GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice.

Kammoun HL, Chabanon H, Hainault I, Luquet S, Magnan C, Koike T, Ferré P, Foufelle F.

J Clin Invest. 2009 May;119(5):1201-15. doi: 10.1172/JCI37007. Epub 2009 Apr 13.


Dietary docosahexaenoic acid-rich diacylglycerols ameliorate hepatic steatosis and alter hepatic gene expressions in C57BL/6J-Lep(ob/ob) mice.

Kim HJ, Lee KT, Park YB, Jeon SM, Choi MS.

Mol Nutr Food Res. 2008 Aug;52(8):965-73. doi: 10.1002/mnfr.200700315.


The C-terminal region of mitochondrial glycerol-3-phosphate acyltransferase-1 interacts with the active site region and is required for activity.

Pellon-Maison M, Coleman RA, Gonzalez-Baró MR.

Arch Biochem Biophys. 2006 Jun 15;450(2):157-66. Epub 2006 Mar 27.


Stearoyl-CoA desaturase 1 deficiency increases CTP:choline cytidylyltransferase translocation into the membrane and enhances phosphatidylcholine synthesis in liver.

Dobrzyn A, Dobrzyn P, Miyazaki M, Sampath H, Chu K, Ntambi JM.

J Biol Chem. 2005 Jun 17;280(24):23356-62. Epub 2005 Apr 13.


Thematic review series: glycerolipids. Mammalian glycerol-3-phosphate acyltransferases: new genes for an old activity.

Gimeno RE, Cao J.

J Lipid Res. 2008 Oct;49(10):2079-88. doi: 10.1194/jlr.R800013-JLR200. Epub 2008 Jul 24. Review.


Regulatory effects of arachidonate 5-lipoxygenase on hepatic microsomal TG transfer protein activity and VLDL-triglyceride and apoB secretion in obese mice.

López-Parra M, Titos E, Horrillo R, Ferré N, González-Périz A, Martínez-Clemente M, Planagumà A, Masferrer J, Arroyo V, Clària J.

J Lipid Res. 2008 Dec;49(12):2513-23. doi: 10.1194/jlr.M800101-JLR200. Epub 2008 Jul 21.

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