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Cyclic flexure and laminar flow synergistically accelerate mesenchymal stem cell-mediated engineered tissue formation: Implications for engineered heart valve tissues.

Engelmayr GC Jr, Sales VL, Mayer JE Jr, Sacks MS. Engelmayr GC Jr, et al. Biomaterials. 2006 Dec;27(36):6083-95. doi: 10.1016/j.biomaterials.2006.07.045. Epub 2006 Aug 23. Biomaterials. 2006. PMID: 16930686

The independent role of cyclic flexure in the early in vitro development of an engineered heart valve tissue.

Engelmayr GC Jr, Rabkin E, Sutherland FW, Schoen FJ, Mayer JE Jr, Sacks MS. Engelmayr GC Jr, et al. Biomaterials. 2005 Jan;26(2):175-87. doi: 10.1016/j.biomaterials.2004.02.035. Biomaterials. 2005. PMID: 15207464

Prediction of extracellular matrix stiffness in engineered heart valve tissues based on nonwoven scaffolds.

Engelmayr GC Jr, Sacks MS. Engelmayr GC Jr, et al. Biomech Model Mechanobiol. 2008 Aug;7(4):309-21. doi: 10.1007/s10237-007-0102-1. Epub 2007 Aug 23. Biomech Model Mechanobiol. 2008. PMID: 17713801

Tissue engineering of autologous human heart valves using cryopreserved vascular umbilical cord cells.

Sodian R, Lueders C, Kraemer L, Kuebler W, Shakibaei M, Reichart B, Daebritz S, Hetzer R. Sodian R, et al. Ann Thorac Surg. 2006 Jun;81(6):2207-16. doi: 10.1016/j.athoracsur.2005.12.073. Ann Thorac Surg. 2006. PMID: 16731156

Differentiation and Distribution of Marrow Stem Cells in Flex-Flow Environments Demonstrate Support of the Valvular Phenotype.

Rath S, Salinas M, Villegas AG, Ramaswamy S. Rath S, et al. PLoS One. 2015 Nov 4;10(11):e0141802. doi: 10.1371/journal.pone.0141802. eCollection 2015. PLoS One. 2015. PMID: 26536240 Free PMC article.

Living autologous heart valves engineered from human prenatally harvested progenitors.

Schmidt D, Mol A, Breymann C, Achermann J, Odermatt B, Gössi M, Neuenschwander S, Prêtre R, Genoni M, Zund G, Hoerstrup SP. Schmidt D, et al. Circulation. 2006 Jul 4;114(1 Suppl):I125-31. doi: 10.1161/CIRCULATIONAHA.105.001040. Circulation. 2006. PMID: 16820561

The role of organ level conditioning on the promotion of engineered heart valve tissue development in-vitro using mesenchymal stem cells.

Ramaswamy S, Gottlieb D, Engelmayr GC Jr, Aikawa E, Schmidt DE, Gaitan-Leon DM, Sales VL, Mayer JE Jr, Sacks MS. Ramaswamy S, et al. Biomaterials. 2010 Feb;31(6):1114-25. doi: 10.1016/j.biomaterials.2009.10.019. Epub 2009 Nov 26. Biomaterials. 2010. PMID: 19944458 Free PMC article.

Computational simulations predict a key role for oscillatory fluid shear stress in de novo valvular tissue formation.

Salinas M, Ramaswamy S. Salinas M, et al. J Biomech. 2014 Nov 7;47(14):3517-23. doi: 10.1016/j.jbiomech.2014.08.028. Epub 2014 Sep 16. J Biomech. 2014. PMID: 25262874

Mechano-active tissue engineering of vascular smooth muscle using pulsatile perfusion bioreactors and elastic PLCL scaffolds.

Jeong SI, Kwon JH, Lim JI, Cho SW, Jung Y, Sung WJ, Kim SH, Kim YH, Lee YM, Kim BS, Choi CY, Kim SJ. Jeong SI, et al. Biomaterials. 2005 Apr;26(12):1405-11. doi: 10.1016/j.biomaterials.2004.04.036. Biomaterials. 2005. PMID: 15482828

A novel flex-stretch-flow bioreactor for the study of engineered heart valve tissue mechanobiology.

Engelmayr GC Jr, Soletti L, Vigmostad SC, Budilarto SG, Federspiel WJ, Chandran KB, Vorp DA, Sacks MS. Engelmayr GC Jr, et al. Ann Biomed Eng. 2008 May;36(5):700-12. doi: 10.1007/s10439-008-9447-6. Epub 2008 Feb 6. Ann Biomed Eng. 2008. PMID: 18253834 Free PMC article.

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