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Items: 1 to 20 of 105

1.

Proteasome inhibitor PS-341 induces apoptosis in cisplatin-resistant squamous cell carcinoma cells by induction of Noxa.

Fribley AM, Evenchik B, Zeng Q, Park BK, Guan JY, Zhang H, Hale TJ, Soengas MS, Kaufman RJ, Wang CY.

J Biol Chem. 2006 Oct 20;281(42):31440-7. Epub 2006 Aug 23.

2.
3.

Proteasome inhibitors trigger NOXA-mediated apoptosis in melanoma and myeloma cells.

Qin JZ, Ziffra J, Stennett L, Bodner B, Bonish BK, Chaturvedi V, Bennett F, Pollock PM, Trent JM, Hendrix MJ, Rizzo P, Miele L, Nickoloff BJ.

Cancer Res. 2005 Jul 15;65(14):6282-93.

4.

Characterization of bortezomib-adapted I-45 mesothelioma cells.

Zhang L, Littlejohn JE, Cui Y, Cao X, Peddaboina C, Smythe WR.

Mol Cancer. 2010 May 18;9:110. doi: 10.1186/1476-4598-9-110.

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6.

Molecular characterization of PS-341 (bortezomib) resistance: implications for overcoming resistance using lysophosphatidic acid acyltransferase (LPAAT)-beta inhibitors.

Hideshima T, Chauhan D, Ishitsuka K, Yasui H, Raje N, Kumar S, Podar K, Mitsiades C, Hideshima H, Bonham L, Munshi NC, Richardson PG, Singer JW, Anderson KC.

Oncogene. 2005 Apr 28;24(19):3121-9.

PMID:
15735676
8.

The proteasome inhibitor bortezomib induces apoptosis in mantle-cell lymphoma through generation of ROS and Noxa activation independent of p53 status.

Pérez-Galán P, Roué G, Villamor N, Montserrat E, Campo E, Colomer D.

Blood. 2006 Jan 1;107(1):257-64. Epub 2005 Sep 15.

9.

Sensitization of DNA damage-induced apoptosis by the proteasome inhibitor PS-341 is p53 dependent and involves target proteins 14-3-3sigma and survivin.

Vaziri SA, Hill J, Chikamori K, Grabowski DR, Takigawa N, Chawla-Sarkar M, Rybicki LR, Gudkov AV, Mekhail T, Bukowski RM, Ganapathi MK, Ganapathi R.

Mol Cancer Ther. 2005 Dec;4(12):1880-90.

10.

Proteasome inhibitor induces apoptosis through induction of endoplasmic reticulum stress.

Fribley A, Wang CY.

Cancer Biol Ther. 2006 Jul;5(7):745-8. Epub 2006 Jul 1.

PMID:
16861900
11.

Reversal of cisplatin resistance with a BH3 mimetic, (-)-gossypol, in head and neck cancer cells: role of wild-type p53 and Bcl-xL.

Bauer JA, Trask DK, Kumar B, Los G, Castro J, Lee JS, Chen J, Wang S, Bradford CR, Carey TE.

Mol Cancer Ther. 2005 Jul;4(7):1096-104.

12.

The BH3-mimetic GX15-070 synergizes with bortezomib in mantle cell lymphoma by enhancing Noxa-mediated activation of Bak.

Pérez-Galán P, Roué G, Villamor N, Campo E, Colomer D.

Blood. 2007 May 15;109(10):4441-9. Epub 2007 Jan 16.

13.

Ritonavir induces endoplasmic reticulum stress and sensitizes sarcoma cells toward bortezomib-induced apoptosis.

Kraus M, Malenke E, Gogel J, Müller H, Rückrich T, Overkleeft H, Ovaa H, Koscielniak E, Hartmann JT, Driessen C.

Mol Cancer Ther. 2008 Jul;7(7):1940-8. doi: 10.1158/1535-7163.MCT-07-2375.

14.

Extensive immunoglobulin production sensitizes myeloma cells for proteasome inhibition.

Meister S, Schubert U, Neubert K, Herrmann K, Burger R, Gramatzki M, Hahn S, Schreiber S, Wilhelm S, Herrmann M, Jäck HM, Voll RE.

Cancer Res. 2007 Feb 15;67(4):1783-92.

15.

PS-341, a novel proteasome inhibitor, induces Bcl-2 phosphorylation and cleavage in association with G2-M phase arrest and apoptosis.

Ling YH, Liebes L, Ng B, Buckley M, Elliott PJ, Adams J, Jiang JD, Muggia FM, Perez-Soler R.

Mol Cancer Ther. 2002 Aug;1(10):841-9.

16.

Down-regulation of phospho-Akt is a major molecular determinant of bortezomib-induced apoptosis in hepatocellular carcinoma cells.

Chen KF, Yeh PY, Yeh KH, Lu YS, Huang SY, Cheng AL.

Cancer Res. 2008 Aug 15;68(16):6698-707. doi: 10.1158/0008-5472.CAN-08-0257.

17.

Vitamin C inactivates the proteasome inhibitor PS-341 in human cancer cells.

Zou W, Yue P, Lin N, He M, Zhou Z, Lonial S, Khuri FR, Wang B, Sun SY.

Clin Cancer Res. 2006 Jan 1;12(1):273-80.

18.

Cisplatin overcomes Bcl-2-mediated resistance to apoptosis via preferential engagement of Bak: critical role of Noxa-mediated lipid peroxidation.

Kutuk O, Arisan ED, Tezil T, Shoshan MC, Basaga H.

Carcinogenesis. 2009 Sep;30(9):1517-27. doi: 10.1093/carcin/bgp165. Epub 2009 Jul 3.

PMID:
19578044
19.

Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis.

Nguyen M, Marcellus RC, Roulston A, Watson M, Serfass L, Murthy Madiraju SR, Goulet D, Viallet J, Bélec L, Billot X, Acoca S, Purisima E, Wiegmans A, Cluse L, Johnstone RW, Beauparlant P, Shore GC.

Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19512-7. Epub 2007 Nov 26.

20.

Enhancement of cisplatin cytotoxicity by SAHA involves endoplasmic reticulum stress-mediated apoptosis in oral squamous cell carcinoma cells.

Suzuki M, Endo M, Shinohara F, Echigo S, Rikiishi H.

Cancer Chemother Pharmacol. 2009 Nov;64(6):1115-22. doi: 10.1007/s00280-009-0969-x. Epub 2009 Mar 11.

PMID:
19280190

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