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Essential CDK1-inhibitory role for separase during meiosis I in vertebrate oocytes.

Gorr IH, Reis A, Boos D, Wühr M, Madgwick S, Jones KT, Stemmann O.

Nat Cell Biol. 2006 Sep;8(9):1035-7. Epub 2006 Aug 13.


Mutual inhibition of separase and Cdk1 by two-step complex formation.

Gorr IH, Boos D, Stemmann O.

Mol Cell. 2005 Jul 1;19(1):135-41.


Anaphase topsy-turvy: Cdk1 a securin, separase a CKI.

Stemmann O, Gorr IH, Boos D.

Cell Cycle. 2006 Jan;5(1):11-3. Epub 2006 Jan 4. Review.


The meiosis I-to-meiosis II transition in mouse oocytes requires separase activity.

Terret ME, Wassmann K, Waizenegger I, Maro B, Peters JM, Verlhac MH.

Curr Biol. 2003 Oct 14;13(20):1797-802.


Cyclin A2 is required for sister chromatid segregation, but not separase control, in mouse oocyte meiosis.

Touati SA, Cladière D, Lister LM, Leontiou I, Chambon JP, Rattani A, Böttger F, Stemmann O, Nasmyth K, Herbert M, Wassmann K.

Cell Rep. 2012 Nov 29;2(5):1077-87. doi: 10.1016/j.celrep.2012.10.002. Epub 2012 Nov 1.


Securin and not CDK1/cyclin B1 regulates sister chromatid disjunction during meiosis II in mouse eggs.

Nabti I, Reis A, Levasseur M, Stemmann O, Jones KT.

Dev Biol. 2008 Sep 15;321(2):379-86. doi: 10.1016/j.ydbio.2008.06.036. Epub 2008 Jul 4.


From ubiquitin-proteasomal degradation to CDK1 inactivation: requirements for the first polar body extrusion in mouse oocytes.

Pomerantz Y, Elbaz J, Ben-Eliezer I, Reizel Y, David Y, Galiani D, Nevo N, Navon A, Dekel N.

FASEB J. 2012 Nov;26(11):4495-505. doi: 10.1096/fj.12-209866. Epub 2012 Aug 2.


Separase sensor reveals dual roles for separase coordinating cohesin cleavage and cdk1 inhibition.

Shindo N, Kumada K, Hirota T.

Dev Cell. 2012 Jul 17;23(1):112-23. doi: 10.1016/j.devcel.2012.06.015.


Role of cleavage by separase of the Rec8 kleisin subunit of cohesin during mammalian meiosis I.

Kudo NR, Anger M, Peters AH, Stemmann O, Theussl HC, Helmhart W, Kudo H, Heyting C, Nasmyth K.

J Cell Sci. 2009 Aug 1;122(Pt 15):2686-98. doi: 10.1242/jcs.035287.


Dual inhibition of sister chromatid separation at metaphase.

Stemmann O, Zou H, Gerber SA, Gygi SP, Kirschner MW.

Cell. 2001 Dec 14;107(6):715-26.


Resolution of chiasmata in oocytes requires separase-mediated proteolysis.

Kudo NR, Wassmann K, Anger M, Schuh M, Wirth KG, Xu H, Helmhart W, Kudo H, McKay M, Maro B, Ellenberg J, de Boer P, Nasmyth K.

Cell. 2006 Jul 14;126(1):135-46.


Role of Securin, Separase and Cohesins in female meiosis and polar body formation in Drosophila.

Guo Z, Batiha O, Bourouh M, Fifield E, Swan A.

J Cell Sci. 2016 Feb 1;129(3):531-42. doi: 10.1242/jcs.179358. Epub 2015 Dec 16.


Phosphorylation-dependent binding of cyclin B1 to a Cdc6-like domain of human separase.

Boos D, Kuffer C, Lenobel R, Körner R, Stemmann O.

J Biol Chem. 2008 Jan 11;283(2):816-23. Epub 2007 Nov 1.


Positive and negative regulation of vertebrate separase by Cdk1-cyclin B1 may explain why securin is dispensable.

Hellmuth S, Pöhlmann C, Brown A, Böttger F, Sprinzl M, Stemmann O.

J Biol Chem. 2015 Mar 20;290(12):8002-10. doi: 10.1074/jbc.M114.615310. Epub 2015 Feb 6.


The yeast APC/C subunit Mnd2 prevents premature sister chromatid separation triggered by the meiosis-specific APC/C-Ama1.

Oelschlaegel T, Schwickart M, Matos J, Bogdanova A, Camasses A, Havlis J, Shevchenko A, Zachariae W.

Cell. 2005 Mar 25;120(6):773-88.


Meiosis: separase strikes twice.

Terret ME, Jallepalli PV.

Nat Cell Biol. 2006 Sep;8(9):910-1. No abstract available.


Cyclin-B1-mediated inhibition of excess separase is required for timely chromosome disjunction.

Holland AJ, Taylor SS.

J Cell Sci. 2006 Aug 15;119(Pt 16):3325-36. Epub 2006 Jul 25.


Age-dependent susceptibility of chromosome cohesion to premature separase activation in mouse oocytes.

Chiang T, Schultz RM, Lampson MA.

Biol Reprod. 2011 Dec;85(6):1279-83. doi: 10.1095/biolreprod.111.094094. Epub 2011 Aug 24.


Mad2 is required for inhibiting securin and cyclin B degradation following spindle depolymerisation in meiosis I mouse oocytes.

Homer HA, McDougall A, Levasseur M, Murdoch AP, Herbert M.

Reproduction. 2005 Dec;130(6):829-43.

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