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Items: 1 to 20 of 129

1.
2.

AID recruits UNG and Msh2 to Ig switch regions dependent upon the AID C terminus [corrected].

Ranjit S, Khair L, Linehan EK, Ucher AJ, Chakrabarti M, Schrader CE, Stavnezer J.

J Immunol. 2011 Sep 1;187(5):2464-75. doi: 10.4049/jimmunol.1101406. Epub 2011 Jul 29. Erratum in: J Immunol. 2014 May 15;192(10):4934.

3.

AID-associated DNA repair pathways regulate malignant transformation in a murine model of BCL6-driven diffuse large B-cell lymphoma.

Gu X, Booth CJ, Liu Z, Strout MP.

Blood. 2016 Jan 7;127(1):102-12. doi: 10.1182/blood-2015-02-628164. Epub 2015 Sep 18.

4.

Single-strand DNA breaks in Ig class switch recombination that depend on UNG but not AID.

Arudchandran A, Bernstein RM, Max EE.

Int Immunol. 2008 Nov;20(11):1381-93. doi: 10.1093/intimm/dxn097. Epub 2008 Sep 15.

PMID:
18794203
5.

Rev1 recruits ung to switch regions and enhances du glycosylation for immunoglobulin class switch DNA recombination.

Zan H, White CA, Thomas LM, Mai T, Li G, Xu Z, Zhang J, Casali P.

Cell Rep. 2012 Nov 29;2(5):1220-32. doi: 10.1016/j.celrep.2012.09.029. Epub 2012 Nov 8.

6.

Interplay between Target Sequences and Repair Pathways Determines Distinct Outcomes of AID-Initiated Lesions.

Chen Z, Eder MD, Elos MT, Viboolsittiseri SS, Chen X, Wang JH.

J Immunol. 2016 Mar 1;196(5):2335-47. doi: 10.4049/jimmunol.1502184. Epub 2016 Jan 25.

7.

Immunoglobulin switch mu sequence causes RNA polymerase II accumulation and reduces dA hypermutation.

Rajagopal D, Maul RW, Ghosh A, Chakraborty T, Khamlichi AA, Sen R, Gearhart PJ.

J Exp Med. 2009 Jun 8;206(6):1237-44. doi: 10.1084/jem.20082514. Epub 2009 May 11.

8.
10.

Uracil residues dependent on the deaminase AID in immunoglobulin gene variable and switch regions.

Maul RW, Saribasak H, Martomo SA, McClure RL, Yang W, Vaisman A, Gramlich HS, Schatz DG, Woodgate R, Wilson DM 3rd, Gearhart PJ.

Nat Immunol. 2011 Jan;12(1):70-6. doi: 10.1038/ni.1970. Epub 2010 Dec 12.

11.

Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice.

Rada C, Williams GT, Nilsen H, Barnes DE, Lindahl T, Neuberger MS.

Curr Biol. 2002 Oct 15;12(20):1748-55.

12.

Differential regulation of S-region hypermutation and class-switch recombination by noncanonical functions of uracil DNA glycosylase.

Yousif AS, Stanlie A, Mondal S, Honjo T, Begum NA.

Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):E1016-24. doi: 10.1073/pnas.1402391111. Epub 2014 Mar 3.

13.

UNG shapes the specificity of AID-induced somatic hypermutation.

Pérez-Durán P, Belver L, de Yébenes VG, Delgado P, Pisano DG, Ramiro AR.

J Exp Med. 2012 Jul 2;209(7):1379-89. doi: 10.1084/jem.20112253. Epub 2012 Jun 4.

14.

Analysis of Ig gene hypermutation in Ung(-/-)Polh(-/-) mice suggests that UNG and A:T mutagenesis pathway target different U:G lesions.

Li S, Zhao Y, Wang JY.

Mol Immunol. 2013 Mar;53(3):214-7. doi: 10.1016/j.molimm.2012.08.009. Epub 2012 Sep 4.

PMID:
22960197
15.

The very 5' end and the constant region of Ig genes are spared from somatic mutation because AID does not access these regions.

Longerich S, Tanaka A, Bozek G, Nicolae D, Storb U.

J Exp Med. 2005 Nov 21;202(10):1443-54.

16.

Controlling somatic hypermutation in immunoglobulin variable and switch regions.

Maul RW, Gearhart PJ.

Immunol Res. 2010 Jul;47(1-3):113-22. doi: 10.1007/s12026-009-8142-5. Review.

17.

Uracil DNA glycosylase activity is dispensable for immunoglobulin class switch.

Begum NA, Kinoshita K, Kakazu N, Muramatsu M, Nagaoka H, Shinkura R, Biniszkiewicz D, Boyer LA, Jaenisch R, Honjo T.

Science. 2004 Aug 20;305(5687):1160-3.

18.

Molecular mechanisms of antibody somatic hypermutation.

Di Noia JM, Neuberger MS.

Annu Rev Biochem. 2007;76:1-22. Review.

PMID:
17328676
19.

Somatic hypermutation and class switch recombination in Msh6(-/-)Ung(-/-) double-knockout mice.

Shen HM, Tanaka A, Bozek G, Nicolae D, Storb U.

J Immunol. 2006 Oct 15;177(8):5386-92.

20.

Uracil excision by endogenous SMUG1 glycosylase promotes efficient Ig class switching and impacts on A:T substitutions during somatic mutation.

Dingler FA, Kemmerich K, Neuberger MS, Rada C.

Eur J Immunol. 2014 Jul;44(7):1925-35. doi: 10.1002/eji.201444482. Epub 2014 May 27.

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