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Items: 1 to 20 of 49

1.

Inhibitors of mitotic kinesins: next-generation antimitotics.

Sarli V, Giannis A.

ChemMedChem. 2006 Mar;1(3):293-8. Review. No abstract available.

PMID:
16892362
2.

Synthesis and biological evaluation of novel EG5 inhibitors.

Sarli V, Huemmer S, Sunder-Plassmann N, Mayer TU, Giannis A.

Chembiochem. 2005 Nov;6(11):2005-13.

PMID:
16216042
3.

Kinesins and cancer.

Rath O, Kozielski F.

Nat Rev Cancer. 2012 Jul 24;12(8):527-39. doi: 10.1038/nrc3310. Review.

PMID:
22825217
4.

Screening for inhibitors of microtubule-associated motor proteins.

Kozielski F, DeBonis S, Skoufias DA.

Methods Mol Med. 2007;137:189-207.

PMID:
18085231
5.

Kinesin spindle protein (KSP) inhibitors. Part 8: Design and synthesis of 1,4-diaryl-4,5-dihydropyrazoles as potent inhibitors of the mitotic kinesin KSP.

Roecker AJ, Coleman PJ, Mercer SP, Schreier JD, Buser CA, Walsh ES, Hamilton K, Lobell RB, Tao W, Diehl RE, South VJ, Davide JP, Kohl NE, Yan Y, Kuo LC, Li C, Fernandez-Metzler C, Mahan EA, Prueksaritanont T, Hartman GD.

Bioorg Med Chem Lett. 2007 Oct 15;17(20):5677-82. Epub 2007 Aug 21.

PMID:
17766111
6.

Kinesin spindle protein (KSP) inhibitors. Part 1: The discovery of 3,5-diaryl-4,5-dihydropyrazoles as potent and selective inhibitors of the mitotic kinesin KSP.

Cox CD, Breslin MJ, Mariano BJ, Coleman PJ, Buser CA, Walsh ES, Hamilton K, Huber HE, Kohl NE, Torrent M, Yan Y, Kuo LC, Hartman GD.

Bioorg Med Chem Lett. 2005 Apr 15;15(8):2041-5.

PMID:
15808464
7.

Mitotic kinesins: prospects for antimitotic drug discovery.

Bergnes G, Brejc K, Belmont L.

Curr Top Med Chem. 2005;5(2):127-45. Review.

PMID:
15853642
8.

Proteome analysis of apoptosis signaling by S-trityl-L-cysteine, a potent reversible inhibitor of human mitotic kinesin Eg5.

Kozielski F, Skoufias DA, Indorato RL, Saoudi Y, Jungblut PR, Hustoft HK, Strozynski M, Thiede B.

Proteomics. 2008 Jan;8(2):289-300. doi: 10.1002/pmic.200700534.

PMID:
18186019
9.

Discovery and biochemical characterization of selective ATP competitive inhibitors of the human mitotic kinesin KSP.

Rickert KW, Schaber M, Torrent M, Neilson LA, Tasber ES, Garbaccio R, Coleman PJ, Harvey D, Zhang Y, Yang Y, Marshall G, Lee L, Walsh ES, Hamilton K, Buser CA.

Arch Biochem Biophys. 2008 Jan 15;469(2):220-31. Epub 2007 Nov 1.

PMID:
17999913
10.

Kinesin spindle protein (KSP) inhibitors. Part 7: Design and synthesis of 3,3-disubstituted dihydropyrazolobenzoxazines as potent inhibitors of the mitotic kinesin KSP.

Garbaccio RM, Tasber ES, Neilson LA, Coleman PJ, Fraley ME, Olson C, Bergman J, Torrent M, Buser CA, Rickert K, Walsh ES, Hamilton K, Lobell RB, Tao W, South VJ, Diehl RE, Davide JP, Yan Y, Kuo LC, Li C, Prueksaritanont T, Fernandez-Metzler C, Mahan EA, Slaughter DE, Salata JJ, Kohl NE, Huber HE, Hartman GD.

Bioorg Med Chem Lett. 2007 Oct 15;17(20):5671-6. Epub 2007 Aug 21.

PMID:
17804233
11.

Mitotic kinesin inhibitors induce mitotic arrest and cell death in Taxol-resistant and -sensitive cancer cells.

Marcus AI, Peters U, Thomas SL, Garrett S, Zelnak A, Kapoor TM, Giannakakou P.

J Biol Chem. 2005 Mar 25;280(12):11569-77. Epub 2005 Jan 13.

12.

Development and biological evaluation of potent and specific inhibitors of mitotic Kinesin Eg5.

Gartner M, Sunder-Plassmann N, Seiler J, Utz M, Vernos I, Surrey T, Giannis A.

Chembiochem. 2005 Jul;6(7):1173-7. No abstract available.

PMID:
15912555
13.

Synthesis and biological evaluation of new tetrahydro-beta-carbolines as inhibitors of the mitotic kinesin Eg5.

Sunder-Plassmann N, Sarli V, Gartner M, Utz M, Seiler J, Huemmer S, Mayer TU, Surrey T, Giannis A.

Bioorg Med Chem. 2005 Nov 15;13(22):6094-111. Epub 2005 Aug 3.

PMID:
16084101
14.

Antitumor activity of a kinesin inhibitor.

Sakowicz R, Finer JT, Beraud C, Crompton A, Lewis E, Fritsch A, Lee Y, Mak J, Moody R, Turincio R, Chabala JC, Gonzales P, Roth S, Weitman S, Wood KW.

Cancer Res. 2004 May 1;64(9):3276-80.

15.

Kinesin spindle protein (KSP) inhibitors. Part 6: Design and synthesis of 3,5-diaryl-4,5-dihydropyrazole amides as potent inhibitors of the mitotic kinesin KSP.

Coleman PJ, Schreier JD, Cox CD, Fraley ME, Garbaccio RM, Buser CA, Walsh ES, Hamilton K, Lobell RB, Rickert K, Tao W, Diehl RE, South VJ, Davide JP, Kohl NE, Yan Y, Kuo L, Prueksaritanont T, Li C, Mahan EA, Fernandez-Metzler C, Salata JJ, Hartman GD.

Bioorg Med Chem Lett. 2007 Oct 1;17(19):5390-5. Epub 2007 Aug 6.

PMID:
17761419
16.

S-trityl-L-cysteine is a reversible, tight binding inhibitor of the human kinesin Eg5 that specifically blocks mitotic progression.

Skoufias DA, DeBonis S, Saoudi Y, Lebeau L, Crevel I, Cross R, Wade RH, Hackney D, Kozielski F.

J Biol Chem. 2006 Jun 30;281(26):17559-69. Epub 2006 Feb 28.

17.

Inhibitors of human mitotic kinesin Eg5: characterization of the 4-phenyl-tetrahydroisoquinoline lead series.

Tarby CM, Kaltenbach RF 3rd, Huynh T, Pudzianowski A, Shen H, Ortega-Nanos M, Sheriff S, Newitt JA, McDonnell PA, Burford N, Fairchild CR, Vaccaro W, Chen Z, Borzilleri RM, Naglich J, Lombardo LJ, Gottardis M, Trainor GL, Roussell DL.

Bioorg Med Chem Lett. 2006 Apr 15;16(8):2095-100. Epub 2006 Feb 3.

PMID:
16458511
18.

Recent progress in discovery and development of antimitotic agents.

Kiselyov A, Balakin KV, Tkachenko SE, Savchuk N, Ivachtchenko AV.

Anticancer Agents Med Chem. 2007 Mar;7(2):189-208. Review.

PMID:
17348827
19.

Divide and conquer: new generation of drugs targets mitosis.

Garber K.

J Natl Cancer Inst. 2005 Jun 15;97(12):874-6. No abstract available.

PMID:
15956646
20.

Tubulin-associated drug targets: Aurora kinases, Polo-like kinases, and others.

Warner SL, Gray PJ, Von Hoff DD.

Semin Oncol. 2006 Aug;33(4):436-48. Review.

PMID:
16890798

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