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Items: 1 to 20 of 163

1.

Synthesis of highly substituted dibenzo[b,f]azocines and their evaluation as protein kinase inhibitors.

Arnold LA, Kiplin Guy R.

Bioorg Med Chem Lett. 2006 Oct 15;16(20):5360-3.

PMID:
16890431
3.

Ruthenium half-sandwich complexes as protein kinase inhibitors: derivatization of the pyridocarbazole pharmacophore ligand.

Pagano N, Maksimoska J, Bregman H, Williams DS, Webster RD, Xue F, Meggers E.

Org Biomol Chem. 2007 Apr 21;5(8):1218-27.

PMID:
17406720
4.

Discovery and in vitro evaluation of potent kinase inhibitors: Pyrido[1',2':1,5]pyrazolo[3,4-d]pyrimidines.

Alberti MJ, Auten EP, Lackey KE, McDonald OB, Wood ER, Preugschat F, Cutler GJ, Kane-Carson L, Liu W, Jung DK.

Bioorg Med Chem Lett. 2005 Aug 15;15(16):3778-81.

PMID:
15993060
5.

Synthesis of quinazolines as tyrosine kinase inhibitors.

Srivastava SK, Kumar V, Agarwal SK, Mukherjee R, Burman AC.

Anticancer Agents Med Chem. 2009 Mar;9(3):246-75. Review.

PMID:
19275520
6.

Structure-based design of novel 2-amino-6-phenyl-pyrimido[5',4':5,6]pyrimido[1,2-a]benzimidazol-5(6H)-ones as potent and orally active inhibitors of lymphocyte specific kinase (Lck): synthesis, SAR, and in vivo anti-inflammatory activity.

Martin MW, Newcomb J, Nunes JJ, Boucher C, Chai L, Epstein LF, Faust T, Flores S, Gallant P, Gore A, Gu Y, Hsieh F, Huang X, Kim JL, Middleton S, Morgenstern K, Oliveira-dos-Santos A, Patel VF, Powers D, Rose P, Tudor Y, Turci SM, Welcher AA, Zack D, Zhao H, Zhu L, Zhu X, Ghiron C, Ermann M, Johnston D, Saluste CG.

J Med Chem. 2008 Mar 27;51(6):1637-48. doi: 10.1021/jm701095m.

PMID:
18278858
7.

Aza-stilbenes as potent and selective c-RAF inhibitors.

McDonald O, Lackey K, Davis-Ward R, Wood E, Samano V, Maloney P, Deanda F, Hunter R.

Bioorg Med Chem Lett. 2006 Oct 15;16(20):5378-83.

PMID:
16890436
9.

Synthesis of novel 5-substituted indirubins as protein kinases inhibitors.

Beauchard A, Ferandin Y, Frère S, Lozach O, Blairvacq M, Meijer L, Thiéry V, Besson T.

Bioorg Med Chem. 2006 Sep 15;14(18):6434-43.

PMID:
16759872
10.

Synthesis and evaluation of 3-phenylpyrazolo[3,4-d]pyrimidine-peptide conjugates as Src kinase inhibitors.

Kumar A, Wang Y, Lin X, Sun G, Parang K.

ChemMedChem. 2007 Sep;2(9):1346-60.

PMID:
17530729
11.

IRAK-4 inhibitors. Part III: a series of imidazo[1,2-a]pyridines.

Buckley GM, Fosbeary R, Fraser JL, Gowers L, Higueruelo AP, James LA, Jenkins K, Mack SR, Morgan T, Parry DM, Pitt WR, Rausch O, Richard MD, Sabin V.

Bioorg Med Chem Lett. 2008 Jun 15;18(12):3656-60. doi: 10.1016/j.bmcl.2008.04.042.

PMID:
18501603
12.

4-Anilino-7-alkenylquinoline-3-carbonitriles as potent MEK1 kinase inhibitors.

Berger DM, Dutia M, Powell D, Floyd MB, Torres N, Mallon R, Wojciechowicz D, Kim S, Feldberg L, Collins K, Chaudhary I.

Bioorg Med Chem. 2008 Oct 15;16(20):9202-11. doi: 10.1016/j.bmc.2008.09.009.

PMID:
18815050
13.

Synthesis and SAR of new pyrrolo[2,1-f][1,2,4]triazines as potent p38 alpha MAP kinase inhibitors.

Wrobleski ST, Lin S, Hynes J Jr, Wu H, Pitt S, Shen DR, Zhang R, Gillooly KM, Shuster DJ, McIntyre KW, Doweyko AM, Kish KF, Tredup JA, Duke GJ, Sack JS, McKinnon M, Dodd J, Barrish JC, Schieven GL, Leftheris K.

Bioorg Med Chem Lett. 2008 Apr 15;18(8):2739-44. doi: 10.1016/j.bmcl.2008.02.067.

PMID:
18364256
14.

Structure and activity relationship of 2-(substituted benzoyl)-hydroxyindoles as novel CaMKII inhibitors.

Komiya M, Asano S, Koike N, Koga E, Igarashi J, Nakatani S, Isobe Y.

Bioorg Med Chem Lett. 2011 Mar 1;21(5):1456-8. doi: 10.1016/j.bmcl.2011.01.012.

PMID:
21292482
15.

Design and synthesis of Rho kinase inhibitors (II).

Iwakubo M, Takami A, Okada Y, Kawata T, Tagami Y, Ohashi H, Sato M, Sugiyama T, Fukushima K, Iijima H.

Bioorg Med Chem. 2007 Jan 1;15(1):350-64.

PMID:
17046269
16.

Synthesis and biological evaluation of 5-substituted 1,4-dihydroindeno[1,2-c]pyrazoles as multitargeted receptor tyrosine kinase inhibitors.

Akritopoulou-Zanze I, Albert DH, Bousquet PF, Cunha GA, Harris CM, Moskey M, Dinges J, Stewart KD, Sowin TJ.

Bioorg Med Chem Lett. 2007 Jun 1;17(11):3136-40.

PMID:
17391959
17.

The development of 2-benzimidazole substituted pyrimidine based inhibitors of lymphocyte specific kinase (Lck).

Sabat M, VanRens JC, Laufersweiler MJ, Brugel TA, Maier J, Golebiowski A, De B, Easwaran V, Hsieh LC, Walter RL, Mekel MJ, Evdokimov A, Janusz MJ.

Bioorg Med Chem Lett. 2006 Dec 1;16(23):5973-7.

PMID:
16997556
18.

Enantioselective rhodium-catalyzed [4+2+2] cycloaddition of dienyl isocyanates for the synthesis of bicyclic azocine rings.

Yu RT, Friedman RK, Rovis T.

J Am Chem Soc. 2009 Sep 23;131(37):13250-1. doi: 10.1021/ja906641d.

19.

Benzothiazoles as Rho-associated kinase (ROCK-II) inhibitors.

Yin Y, Lin L, Ruiz C, Cameron MD, Pocas J, Grant W, Schröter T, Chen W, Duckett D, Schürer S, Lograsso P, Feng Y.

Bioorg Med Chem Lett. 2009 Dec 1;19(23):6686-90. doi: 10.1016/j.bmcl.2009.09.115.

PMID:
19837589
20.

Synthesis and biological activities of aminopyrimidyl-indoles structurally related to meridianins.

Akue-Gedu R, Debiton E, Ferandin Y, Meijer L, Prudhomme M, Anizon F, Moreau P.

Bioorg Med Chem. 2009 Jul 1;17(13):4420-4. doi: 10.1016/j.bmc.2009.05.017.

PMID:
19477650
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