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Items: 1 to 20 of 150

1.

A novel class of AMPA receptor allosteric modulators. Part 1: design, synthesis, and SAR of 3-aryl-4-cyano-5-substituted-heteroaryl-2-carboxylic acid derivatives.

Fernandez MC, Castaño A, Dominguez E, Escribano A, Jiang D, Jimenez A, Hong E, Hornback WJ, Nisenbaum ES, Rankl N, Tromiczak E, Vaught G, Zarrinmayeh H, Zimmerman DM.

Bioorg Med Chem Lett. 2006 Oct 1;16(19):5057-61. Epub 2006 Aug 1.

PMID:
16879964
2.

A novel class of positive allosteric modulators of AMPA receptors: design, synthesis, and structure-activity relationships of 3-biphenyl-4-yl-4-cyano-5-ethyl-1-methyl-1H-pyrrole-2-carboxylic acid, LY2059346.

Zarrinmayeh H, Tromiczak E, Zimmerman DM, Rankl N, Ho KH, Dominguez E, Castaño A, Escribano A, Fernandez C, Jimenez A, Hornback WJ, Nisenbaum ES.

Bioorg Med Chem Lett. 2006 Oct 1;16(19):5203-6. Epub 2006 Jul 25.

PMID:
16872827
3.

Design, synthesis, and structure-activity relationships of novel bicyclic azole-amines as negative allosteric modulators of metabotropic glutamate receptor 5.

Burdi DF, Hunt R, Fan L, Hu T, Wang J, Guo Z, Huang Z, Wu C, Hardy L, Detheux M, Orsini MA, Quinton MS, Lew R, Spear K.

J Med Chem. 2010 Oct 14;53(19):7107-18. doi: 10.1021/jm100736h.

PMID:
20809633
4.

Allosteric modulators of the AMPA receptor: novel 6-substituted dihydrophthalazines.

Pei XF, Sturgess MA, Valenzuela CF, Maccecchini ML.

Bioorg Med Chem Lett. 1999 Feb 22;9(4):539-42.

PMID:
10098658
5.

N-heterocyclic derived M1 positive allosteric modulators.

Kuduk SD, Di Marco CN, Cofre V, Pitts DR, Ray WJ, Ma L, Wittmann M, Veng L, Seager MA, Koeplinger K, Thompson CD, Hartman GD, Bilodeau MT.

Bioorg Med Chem Lett. 2010 Feb 15;20(4):1334-7. doi: 10.1016/j.bmcl.2010.01.013. Epub 2010 Jan 11.

PMID:
20097564
6.

New fluorinated 1,2,4-benzothiadiazine 1,1-dioxides: discovery of an orally active cognitive enhancer acting through potentiation of the 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid receptors.

Francotte P, Goffin E, Fraikin P, Lestage P, Van Heugen JC, Gillotin F, Danober L, Thomas JY, Chiap P, Caignard DH, Pirotte B, de Tullio P.

J Med Chem. 2010 Feb 25;53(4):1700-11. doi: 10.1021/jm901495t.

PMID:
20108934
7.

Design, synthesis, and pharmacology of novel 7-substituted 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides as positive allosteric modulators of AMPA receptors.

Francotte P, Tullio Pd, Goffin E, Dintilhac G, Graindorge E, Fraikin P, Lestage P, Danober L, Thomas JY, Caignard DH, Pirotte B.

J Med Chem. 2007 Jun 28;50(13):3153-7. Epub 2007 Jun 7.

PMID:
17552506
8.

Substituted benzoxazinones as potent positive allosteric AMPA receptor modulators: part II.

Mueller R, Rachwal S, Tedder ME, Li YX, Zhong S, Hampson A, Ulas J, Varney M, Nielsson L, Rogers G.

Bioorg Med Chem Lett. 2011 Jul 1;21(13):3927-30. doi: 10.1016/j.bmcl.2011.05.024. Epub 2011 May 14.

PMID:
21636273
9.

Benzotriazinone and benzopyrimidinone derivatives as potent positive allosteric AMPA receptor modulators.

Mueller R, Rachwal S, Lee S, Zhong S, Li YX, Haroldsen P, Herbst T, Tanimura S, Varney M, Johnson S, Rogers G, Street LJ.

Bioorg Med Chem Lett. 2011 Oct 15;21(20):6170-5. doi: 10.1016/j.bmcl.2011.07.098. Epub 2011 Aug 12.

PMID:
21889339
10.

Design, synthesis, and AMPA receptor antagonistic activity of a novel 6-nitro-3-oxoquinoxaline-2-carboxylic acid with a substituted phenyl group at the 7 position.

Takano Y, Shiga F, Asano J, Ando N, Uchiki H, Fukuchi K, Anraku T.

Bioorg Med Chem. 2005 Oct 15;13(20):5841-63.

PMID:
15993606
11.

Design and synthesis of a novel series of 1,2-disubstituted cyclopentanes as small, potent potentiators of 2-amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl)propanoic acid (AMPA) receptors.

Shepherd TA, Aikins JA, Bleakman D, Cantrell BE, Rearick JP, Simon RL, Smith EC, Stephenson GA, Zimmerman DM, Mandelzys A, Jarvie KR, Ho K, Deverill M, Kamboj RK.

J Med Chem. 2002 May 9;45(10):2101-11.

PMID:
11985477
12.

Positive allosteric modulators of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor.

Grove SJ, Jamieson C, Maclean JK, Morrow JA, Rankovic Z.

J Med Chem. 2010 Oct 28;53(20):7271-9. doi: 10.1021/jm1000419. No abstract available.

13.

Design and structure-activity relationship of heterocyclic analogs of 4-amino-3-benzimidazol-2-ylhydroquinolin-2-ones as inhibitors of receptor tyrosine kinases.

Frazier K, Jazan E, McBride CM, Pecchi S, Renhowe PA, Shafer CM, Taylor C, Bussiere D, He MM, Jansen JM, Lapointe G, Ma S, Vora J, Wiesmann M.

Bioorg Med Chem Lett. 2006 Apr 15;16(8):2247-51. Epub 2006 Jan 30.

PMID:
16446087
14.

Chemical switch of a metabotropic glutamate receptor 2 silent allosteric modulator into dual metabotropic glutamate receptor 2/3 negative/positive allosteric modulators.

Schann S, Mayer S, Franchet C, Frauli M, Steinberg E, Thomas M, Baron L, Neuville P.

J Med Chem. 2010 Dec 23;53(24):8775-9. doi: 10.1021/jm101069m. Epub 2010 Nov 24.

PMID:
21105727
15.

Benzobistriazinones and related heterocyclic ring systems as potent, orally bioavailable positive allosteric AMPA receptor modulators.

Mueller R, Rachwal S, Varney MA, Johnson SA, Alisala K, Zhong S, Li YX, Haroldsen P, Herbst T, Street LJ.

Bioorg Med Chem Lett. 2011 Dec 15;21(24):7455-9. doi: 10.1016/j.bmcl.2011.09.132. Epub 2011 Oct 8.

PMID:
22056742
16.

A novel series of positive modulators of the AMPA receptor: structure-based lead optimization.

Jamieson C, Campbell RA, Cumming IA, Gillen KJ, Gillespie J, Kazemier B, Kiczun M, Lamont Y, Lyons AJ, Maclean JK, Martin F, Moir EM, Morrow JA, Pantling J, Rankovic Z, Smith L.

Bioorg Med Chem Lett. 2010 Oct 15;20(20):6072-5. doi: 10.1016/j.bmcl.2010.08.063. Epub 2010 Aug 15.

17.

Heterocyclic fused pyridone carboxylic acid M(1) positive allosteric modulators.

Kuduk SD, Di Marco CN, Chang RK, Ray WJ, Ma L, Wittmann M, Seager MA, Koeplinger KA, Thompson CD, Hartman GD, Bilodeau MT.

Bioorg Med Chem Lett. 2010 Apr 15;20(8):2533-7. doi: 10.1016/j.bmcl.2010.02.096. Epub 2010 Mar 3.

PMID:
20303264
18.

Benzoxazinones as potent positive allosteric AMPA receptor modulators: part I.

Mueller R, Li YX, Hampson A, Zhong S, Harris C, Marrs C, Rachwal S, Ulas J, Nielsson L, Rogers G.

Bioorg Med Chem Lett. 2011 Jul 1;21(13):3923-6. doi: 10.1016/j.bmcl.2011.05.026. Epub 2011 May 14.

PMID:
21636275
19.

Heterocyclic modulators of the NMDA receptor.

Pellicciari R, Natalini B, Costantino G, Garzon A, Luneia R, Mahmoud MR, Marinozzi M, Roberti M, Rosato GC, Shiba SA.

Farmaco. 1993 Feb;48(2):151-7. Review.

PMID:
8494596
20.

Synthesis of anticonvulsive AMPA antagonists: 4-oxo-10-substituted-imidaz.

Stutzmann JM, Bohme GA, Boireau A, Damour D, Debono MW, Genevois-Borella A, Jimonet P, Pratt J, Randle JC, Ribeill Y, Vuilhorgne M, Mignani S.

Bioorg Med Chem Lett. 2001 May 7;11(9):1205-10.

PMID:
11354378

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