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Items: 1 to 20 of 151


Have you HRD? Understanding ERAD is DOAble!

Ismail N, Ng DT.

Cell. 2006 Jul 28;126(2):237-9.


An HRD/DER-independent ER quality control mechanism involves Rsp5p-dependent ubiquitination and ER-Golgi transport.

Haynes CM, Caldwell S, Cooper AA.

J Cell Biol. 2002 Jul 8;158(1):91-101. Epub 2002 Jul 8.


The Hrd1p ligase complex forms a linchpin between ER-lumenal substrate selection and Cdc48p recruitment.

Gauss R, Sommer T, Jarosch E.

EMBO J. 2006 May 3;25(9):1827-35. Epub 2006 Apr 13.


Distinct machinery is required in Saccharomyces cerevisiae for the endoplasmic reticulum-associated degradation of a multispanning membrane protein and a soluble luminal protein.

Huyer G, Piluek WF, Fansler Z, Kreft SG, Hochstrasser M, Brodsky JL, Michaelis S.

J Biol Chem. 2004 Sep 10;279(37):38369-78. Epub 2004 Jul 12.


Dissecting the ER-associated degradation of a misfolded polytopic membrane protein.

Nakatsukasa K, Huyer G, Michaelis S, Brodsky JL.

Cell. 2008 Jan 11;132(1):101-12. doi: 10.1016/j.cell.2007.11.023.


Endoplasmic Reticulum-associated Degradation of Pca1p, a Polytopic Protein, via Interaction with the Proteasome at the Membrane.

Smith N, Adle DJ, Zhao M, Qin X, Kim H, Lee J.

J Biol Chem. 2016 Jul 15;291(29):15082-92. doi: 10.1074/jbc.M116.726265. Epub 2016 May 12.


Recognition of an ERAD-L substrate analyzed by site-specific in vivo photocrosslinking.

Stanley AM, Carvalho P, Rapoport T.

FEBS Lett. 2011 May 6;585(9):1281-6. doi: 10.1016/j.febslet.2011.04.009. Epub 2011 Apr 8.


Degradation of a cytosolic protein requires endoplasmic reticulum-associated degradation machinery.

Metzger MB, Maurer MJ, Dancy BM, Michaelis S.

J Biol Chem. 2008 Nov 21;283(47):32302-16. doi: 10.1074/jbc.M806424200. Epub 2008 Sep 23.


A regulatory link between ER-associated protein degradation and the unfolded-protein response.

Friedlander R, Jarosch E, Urban J, Volkwein C, Sommer T.

Nat Cell Biol. 2000 Jul;2(7):379-84.


Ubx2 links the Cdc48 complex to ER-associated protein degradation.

Neuber O, Jarosch E, Volkwein C, Walter J, Sommer T.

Nat Cell Biol. 2005 Oct;7(10):993-8. Epub 2005 Sep 18.


Ubiquitin ligase Hul5 is required for fragment-specific substrate degradation in endoplasmic reticulum-associated degradation.

Kohlmann S, Schäfer A, Wolf DH.

J Biol Chem. 2008 Jun 13;283(24):16374-83. doi: 10.1074/jbc.M801702200. Epub 2008 Apr 24.


Usa1p is required for optimal function and regulation of the Hrd1p endoplasmic reticulum-associated degradation ubiquitin ligase.

Carroll SM, Hampton RY.

J Biol Chem. 2010 Feb 19;285(8):5146-56. doi: 10.1074/jbc.M109.067876. Epub 2009 Nov 24.


Dfm1 forms distinct complexes with Cdc48 and the ER ubiquitin ligases and is required for ERAD.

Stolz A, Schweizer RS, Schäfer A, Wolf DH.

Traffic. 2010 Oct;11(10):1363-9. doi: 10.1111/j.1600-0854.2010.01093.x.


Ubx4 modulates cdc48 activity and influences degradation of misfolded proteins of the endoplasmic reticulum.

Alberts SM, Sonntag C, Schäfer A, Wolf DH.

J Biol Chem. 2009 Jun 12;284(24):16082-9. doi: 10.1074/jbc.M809282200. Epub 2009 Apr 9.


A stalled retrotranslocation complex reveals physical linkage between substrate recognition and proteasomal degradation during ER-associated degradation.

Nakatsukasa K, Brodsky JL, Kamura T.

Mol Biol Cell. 2013 Jun;24(11):1765-75, S1-8. doi: 10.1091/mbc.E12-12-0907. Epub 2013 Mar 27.

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